2009
DOI: 10.1016/j.bbr.2009.06.038
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Behavioral profile and dorsal hippocampal cells in carioca high-conditioned freezing rats

Abstract: Selection for contextual fear conditioning is an important behavioral paradigm for studying the role of genetic variables and their interaction with the surrounding environment in the etiology and development of anxiety disorders. Recently, a new line of animals selectively bred for high levels of freezing in response to contextual cues previously associated with footshock was developed from a Wistar population. The purpose of the present study was to evaluate the emotional and cognitive aspects of this new li… Show more

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Cited by 25 publications
(31 citation statements)
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References 38 publications
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“…The breeding protocol for these animals is based on defensive freezing responses to contextual cues that are associated with electric footshock (Dias et al, 2009;Castro-Gomes and Landeira-Fernandez, 2008). The anxiety-like profile of these animals was confirmed with several behavioral test protocols (Hassan et al, 2013;Dias et al, 2009;Castro-Gomes and LandeiraFernandez, 2008). The levels of reactive species (RS) and rate of lipid peroxidation (LPO) were higher in CHF rats than in CLF rats.…”
Section: Introductionmentioning
confidence: 99%
“…The breeding protocol for these animals is based on defensive freezing responses to contextual cues that are associated with electric footshock (Dias et al, 2009;Castro-Gomes and Landeira-Fernandez, 2008). The anxiety-like profile of these animals was confirmed with several behavioral test protocols (Hassan et al, 2013;Dias et al, 2009;Castro-Gomes and LandeiraFernandez, 2008). The levels of reactive species (RS) and rate of lipid peroxidation (LPO) were higher in CHF rats than in CLF rats.…”
Section: Introductionmentioning
confidence: 99%
“…Therefore, motor activity did not account for the differences between CHF and RDN animals. Dias et al (2009) also found an absence of differences between the CHF and RND lines in the forced swim test, suggesting that the anxiety trait selected in the CHF line did not interact with affective disorder traits, such as those for depression. The cognitive aspects of CHF rats were evaluated in the object recognition task.…”
Section: Behavioral Validation Of the Carioca Linesmentioning
confidence: 83%
“…The first behavioral results from this ongoing selective breeding program were reported by Dias et al (2009). They performed a battery of behavioral tests that evaluated the emotional and cognitive aspects of the 4 th generation of the CHF and RND lines.…”
Section: Behavioral Validation Of the Carioca Linesmentioning
confidence: 99%
“…CMS is an animal model based on environmental manipulations, which induce anhedonia and depressive-like behavior in rodents, as well as physiological alterations, similar to those found in individuals suffering from depression [5,54]. In relation to anxiety, some animals models have been developed to generate both conditioned and unconditioned fears in the same rat, and normally anxious rodents are selectively bred for both high and low levels of freezing in response to contextual cues previously associated with footshock [19,21].…”
Section: Introductionmentioning
confidence: 98%