Behavioral, molecular and physiological responses of embryo-larval zebrafish exposed to types I and II pyrethroids

Adverse effects in the fish embryo acute toxicity (FET) test: a catalogue of unspecific morphological changes versus more specific effects in zebrafish (Danio rerio) embryos

“…Therefore, oedemata in zebrafish appear to be of very little mechanistic value and have to be categorised as an unspecific side effect of both acute and sublethal toxicity [47,48], although oedemata were listed as changes typical of cardiotoxicity [49]. Oedemata have also been described after exposure to petroleum oils [50], nanomaterials [51], parabens [52], endocrine disruptors [53], flame retardants [54,55], pesticides [56], and numerous other classes of compounds. Likewise, physicochemical parameters such as temperature are capable of inducing oedemata in zebrafish embryos [57].…”

Pesticides diazinon and diuron increase glutathione levels and affect multixenobiotic resistance activity and biomarker responses in zebrafish (Danio rerio) embryos and larvae

“…Hence, they have become an important tool in assessing the modes of action and effects of various xenobiotics [4,5]. Not only have they been used for the assessment of toxicant effects on embryonic development [6], but they have also been utilized to analyze changes in behavior (e.g., [7][8][9][10]), altered enzyme activities [4,11], as well as changes on a gene expression level [5,[11][12][13][14] and oxidative stress induction [15], providing valuable data for the risk assessment of xenobiotics and their potential adverse effects on the aquatic environment.…”

Toxicity of Deltamethrin to Zebrafish Gonads Revealed by Cellular Biomarkers

“…There were no differences found in the expression of p53 mRNA in zebrafish larvae exposed to deltamethrin by Awoyemi et al [17] but Maalej et al [48] observed a significant increase, showing that deltamethrin treatment-induced oxidative damage and inflammation through increasing cox-2 expression and initiates a series of cell death signaling events, including p53 activation, leading to DNA fragmentation and apoptosis.…”

“…Regarding the presence of deltamethrin in aquatic ecosystems, various studies concerning its negative effects on various species from the freshwater environments have been conducted in Daphnia magna [12,13], Coenagrion puella [14], Danio rerio [15][16][17], Carassius carassius [18], Eriocheir sinensis [19], Hypophthalmichthys molitrix [20], and Salmo trutta fario [21].…”

“…Research studies conducted on zebrafish model (Danio rerio) with various concentrations of deltamethrin revealed an inhibition of acetylcholinesterase (0.52 µg L −1 , 5.20 µg L −1 , and 10.4 µg L −1 ) [22,23]; embryonic development retardation, larvae malformations, and chorion surface tension reduction (>0.1 µg L −1 ) [24]; oogenesis lagging (0.5 µgL −1 and 1 µgL −1 ) [25]; swimming speed and depth alteration (0.15 µg L −1 , 1.5 µg L −1 , 3.75 µg L −1 , 7.5 µg L −1 , and 15 µg L −1 ) [26]; body axis curvature, pericardial edema and developmental neurotoxicity (10 µg L −1 ) [17,27]. In Carassius carassius DM influenced the cardiac rhythm and the force of contraction (0.1-30.0 µm) [18], meanwhile, in Carassius auratus gibelio determined an oxidative stress response in the liver and intestine (2 µg L −1 ) [28].…”