Behavioral impairments in rats with chronic epilepsy suggest comorbidity between epilepsy and attention deficit/hyperactivity disorder

Pineda, Eduardo; Jentsch, J. David; Shin, Don; Griesbach, Grace S.; Sankar, Raman; Mazarati, Andréy

doi:10.1016/j.yebeh.2013.10.004

Cited by 52 publications

(95 citation statements)

References 78 publications

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“…however, when a delay for reinforcement was used, the performance was reduced, with increased impulsivity and visuospatial working memory impairment, which is prominent in ADhD. interestingly, Pineda et al 18 observed in the LiP model that half the animals exhibited increased impulsivity and diminished attention in the lateralized reaction time test and the other half exhibited depressive related behavior. the seizure frequency ranging from 1 to 5 per week, but any correlation was investigated between the seizures frequency and behavioral changes.…”

Section: Discussionmentioning

confidence: 99%

Impaired executive functions in experimental model of temporal lobe epilepsy

Ramos

Carreiro

Scorza

et al. 2016

Arq. Neuro-Psiquiatr.

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with approximately 65 million people affected worldwide, epilepsy is one of the most common, chronic and serious neurological disease 1,2,3,4 . temporal lobe epilepsy (tLE) is the commonest form of human epilepsy, affecting approximately 40% of patients and often resistant to antiepileptic drugs 5,6,7 . From the structural and functional points of view, tLE is often associated with specific structural abnormalities that affect limbic structures as well as frontal lobe, which is associated with cognitive processes, including executive functions, working memory (wM), decision making, planning, cognitive flexibility and sustained attention 8,9 . Epilepsy is frequently associated with some psychiatry comorbities, such as attention deficit hyperactivity disorder (ADhD) and autism spectrum disorder (ASD). the prevalence of ADhD in children with epilepsy is higher than in general population, being estimated in 30-40% 10,11,12 . Although there is a well-established relationship between the two disorders, the underlying mechanisms are still unclear and more research needs to be performed. thus, the animal models allow investigate many issues related to epilepsy in the absence of iatrogenic neurobehavioral abnormalities. Based on these, the present study aimed to investigate ADhD-like behaviour in male rats with pilocarpine-induced tLE. AbStrACtObjective: The present study aimed to investigate cognitive and behavioural changes consistent with attention deficit hyperactivity disorder (ADHD -like behavior in male Wistar rats with temporal lobe epilepsy (TLE). Method: Male Wistar rats at 25 day of age were submitted to animal model of TLE by pilocarpine injection (350 mg/kg, ip) and a control group received saline 0.9%. The animals were continuously video monitored up to the end of experiments. The behavioural tests (open field, elevated plus maze and operant conditioning box) started from 60 days postnatal. Results: Animals with TLE exhibited elevated locomotor activity, reduced level of anxiety-related behavior, impulsivity and impaired visuospatial working memory. Conclusion: Taken as a whole, we concluded that animals with TLE exhibited some cognitive and behavioural changes consistent with ADHD-like behavior.Keywords: Epilepsy, temporal lobe; executive function; pilocarpine; memory, short-term. reSumo Objetivo: O presente estudo teve como objetivo investigar as alterações cognitivas e comportamentais consistentes com o comportament de transtorno de deficit de atenção e hiperatividade (TDAH) -like em ratos Wistar machos com epilepsia do lobo temporal (ELT). Método: Ratos Wistar machos com 25 dias de vida foram submetidos a modelo animal de ELT pela injeção de pilocarpina (350 mg / kg, ip) e grupo controle recebeu salina 0,9%. Os animais foram monitorados continuamente por vídeo até ao final dos experimentos. Os testes comportamentais (campo aberto, labirinto em cruz elevado e caixa de condicionamento operante) começaram a partir de 60 dias pós-natal. Resultados: Os animais com ELT exibiram aumento da atividade locomoto...

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Section: Discussionmentioning

confidence: 99%

Impaired executive functions in experimental model of temporal lobe epilepsy

Ramos

Carreiro

Scorza

et al. 2016

Arq. Neuro-Psiquiatr.

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“…Em consonância com a condição humana, os modelos animais de epilepsia sugerem a existência de uma associação entre os sintomas de TDAH e de epilepsia. Quando a epilepsia foi induzida em ratos, eles apresentaram hiperatividade e prejuízo das funções executivas, como impulsividade e desatenção (Faure et al, 2014;Pineda et al, 2014;Ramos, Carreiro, Scorza, & Cysneiros, 2016), ou seja, foram secundárias à epilepsia. Pineda et al (2014) associaram o comportamento desatento e impulsivo dos animais com epilepsia do lobo temporal com o prejuízo da transmissão noradrenérgica no locus coeruleus.…”

Section: Resultsunclassified

TDAH nas epilepsias: prevalência e fatores de risco

Pimentel

Cysneiros

2017

Psicologia - Teoria E Prática

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“…Animal models of epilepsy provide additional support for the comorbidity between epilepsy and hyperactivity. In one study, investigators induced SE in adult male Wistar rats with pilocarpine and found that half of the subjects displayed inattention and impulsivity26. For our experiments we only evaluated locomotor activity in the open field and elevated plus maze tests.…”

Section: Discussionmentioning

confidence: 99%

Superimposing Status Epilepticus on Neuron Subset-Specific PTEN Haploinsufficient and Wild Type Mice Results in Long-term Changes in Behavior

Smith

White

Lugo

2016

Sci Rep

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We evaluated the effects of superimposing seizures on a genetic mutation with known involvement in both Autism Spectrum Disorder and in epilepsy. Neuron-subset specific (NS)-Pten heterozygous (HT) and wildtype (WT) adult mice received either intraperitoneal injections of kainic acid (20 mg/kg) to induce status epilepticus or the vehicle (saline). Animals then received a battery of behavioral tasks in order to evaluate activity levels, anxiety, repetitive-stereotyped behavior, social behavior, learning and memory. In the open field task, we found that HT mice after seizures showed a significant increase in total activity and total distance in the surround region of the open field. In the elevated plus maze task, we found that HT mice after seizures displayed increased total distance and velocity as compared to HT mice that did not undergo seizures and WT controls. In the social chamber test, we found the HT mice after seizures displayed an impairment in social behavior. These findings demonstrate that superimposing seizures on a genetic mutation can result in long-term alterations in activity and social behavior in mice.

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Behavioral impairments in rats with chronic epilepsy suggest comorbidity between epilepsy and attention deficit/hyperactivity disorder

Cited by 52 publications

References 78 publications

Impaired executive functions in experimental model of temporal lobe epilepsy

Impaired executive functions in experimental model of temporal lobe epilepsy

TDAH nas epilepsias: prevalência e fatores de risco

Superimposing Status Epilepticus on Neuron Subset-Specific PTEN Haploinsufficient and Wild Type Mice Results in Long-term Changes in Behavior

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