Behavioral impairments in animal models for zinc deficiency

Hagmeyer, Simone; Haderspeck, Jasmin; Grabrucker, Andreas M.

doi:10.3389/fnbeh.2014.00443

Cited by 71 publications

(72 citation statements)

References 163 publications

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“…The main finding of the study is that a 2-week administration of CQ exerts adverse effects on learning and memory performances of treated mice. These results are in line with evidence supporting the critical role played by Zn 2+ in the modulation of neuronal functioning 38,[45][46][47] . The study also indicates that the CQ-dependent effects are mediated by the inhibition of the BDNF neurotrophic axis.…”

Section: Discussionsupporting

confidence: 90%

The pharmacological perturbation of brain zinc impairs BDNF-related signalling and the cognitive performances of young mice

Frazzini

Granzotto

Bomba

et al. 2018

Preprint

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Zinc (Zn 2+ ) is a pleiotropic modulator of the neuronal and brain activity. The disruption of intraneuronal Zn 2+ levels triggers neurotoxic processes and affects neuronal functioning. In this study, we investigated how the pharmacological modulation of brain Zn 2+ affects synaptic plasticity and cognition in wild-type mice. To manipulate brain Zn 2+ levels, we employed the Zn 2+ (and copper) chelator 5-chloro-7iodo-8-hydroxyquinoline (clioquinol, CQ). CQ was administered for two weeks to 2.5-month-old (m.o.) mice, and effects studied on BDNF-related signalling, metalloproteinase activity as well as learning and memory performances. CQ treatment was found to negatively affect short-and long-term memory performances. The CQ-driven perturbation of brain Zn 2+ was found to reduce levels of BDNF, synaptic plasticity-related proteins and dendritic spine density in vivo.Our study highlights the importance of choosing "when", "where", and "how much" in the modulation of brain Zn 2+ levels. Our findings confirm the importance of targeting Zn 2+ as a therapeutic approach against neurodegenerative conditions but, at the same time, underscore the potential drawbacks of reducing brain Zn 2+ availability upon the early stages of development.

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Section: Discussionsupporting

confidence: 90%

The pharmacological perturbation of brain zinc impairs BDNF-related signalling and the cognitive performances of young mice

Frazzini

Granzotto

Bomba

et al. 2018

Preprint

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“…Literatürde çinko eksikliğinin hayvan modellerinde hipokampus bağımlı bellek ve öğrenme üzerinde negatif etkiye yol açtığı, insan çalışmalarında ise dikkat ve kısa dönem bellek problemlerine neden olduğu vurgulanmıştır (2). Literatürde özgül öğrenme güçlüğünde çinko takviyesi verilerek sonuçları ortaya konmuş bir çalışma olamamakla beraber, dikkat eksikliği hiperaktivite bozukluğu olan Türk çocuklarında yapılmış bir çalışma bulunmaktadır.…”

Section: Discussionunclassified

“…İstatistiklere göre; genel dünya popülasyonunun %17,3'ü çinko eksikliği geliştirme riski taşımaktadır (2). Çinko santral sinir sisteminde; proteinlere bağlı-ekstrasellüler veya sitoplazmik-serbest iyonik şekilde olmak üzere iki formda bulunmaktadır (3).…”

Section: Introductionunclassified

“…Gebelik ve yenidoğan dönemindeki eksiklikler; kognitif fonksiyon bozuklukları, bellek problemleri, dikkat sorunları ve nöropsikolojik davranış anormalliklerine yol açabilir (4). Çocukluk çağında düşük çinko değerleri; öğrenme güçlüğü, konsantrasyon bozukluğu, apati, letarji, bellek problemleri ve zihinsel yetersizlik ile ilişkili bulunmuştur (2,6). B12 vitamini ise; metiyonin sentezinde kofaktör rolüne sahiptir ve DNA sentezi için gereklidir.…”

Section: Introductionunclassified

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Zinc and Vitamin B12 Levels in Children with Learning Disabilities

Taskin¹,

Karalök²,

Aydoğmuş³

et al. 2016

jpr

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ÖzABS TRACT Amaç: Çocukluk çağında çinko eksikliği; öğrenme güçlüğü, konsantrasyon bozukluğu, gecikmiş kognitif gelişim ile ilişkiliyken, düşük B12 vitamini düzeyleri ise; duygu-durum ve davranış değişiklikleri ve bellek problemlerine yol açabilmektedir. Amacımız; çinko ve vitamin B12 eksikliklerinin, ülkemizde sık tanımlanan ve bir toplum problemi haline gelmekte olan özgül öğrenme güçlüğüne etkilerinin araştırılmasıdır. Gereç ve Yöntemler: Mart -Aralık 2014 tarihleri arasında, Ankara Çocuk Sağlığı ve Hastalıkları Hematoloji -Onkoloji Eğitim ve Araştırma Hastanesi, Nöroloji Kliniği'ne başvuran, özgül öğrenme güçlüğü tanısı almış olan, 4-18 yaş arasındaki 206 hasta ve pediatri polikliniğine başvuran, 4-18 yaş arasındaki 206 sağlıklı kontrol olmak üzere toplam 412 gönüllü çalışmaya dahil edildi. Bulgular: İki yüz altı hastanın 136'sı (%66) erkek, 70'i (%34) kız; 206 kontrol grubunun 120'si (%58) erkek, 86'sı (%42) kızdı. Hasta ve kontrol gruplarının serum çinko düzeyleri arasında istatistiksel olarak anlamlı farklılık saptanırken (p=0,00), B12 düzeyleri arasında anlamlı farklılık saptanmadı (p=0,12). Sonuç: Çalışmamızda; özgül öğrenme güçlüğü olan çocuklardaki çinko değerleri aynı yaş grubundaki normal çocuklarla karşılaştırıldığında anlamlı olarak düşük bulundu. Özgül öğrenme güçlüğünün çinko eksikliği ile ilişkisinin olduğu, fakat B12 eksikliği ile ilişkisinin olmadığı gösterildi. Sonuç olarak; bu çocuklara son derece kolay olan oral çinko takviyesi vermenin alternatif bir tedavi yaklaşımı olabileceği ortaya kondu. Anahtar Kelimeler: B12 vitamini eksikliği, çinko eksikliği, özgül öğrenme güçlüğü Aim: In childhood, while zinc deficiency is related to learning disabilities, concentration impairment, delayed cognitive development; low vitamin B12 level may lead to memory problems, mood and behavioral changes. Our aim is to investigate the effects of zinc and vitamin B12 deficiencies on learning disabilities, which are being more frequently defined and becoming a social problem in our country. Materials and Methods:This study was performed on a total of 412 children. Two hundred six children with learning disabilities between the ages of 4 and 18, who had been referred to Ankara Pediatric HematologyOncology Training and Research Hospital Neurology Clinic; and 206 healthy controls between the ages of 4 and 18, who applied the to pediatrics clinic, between March and December 2014 were included in the study. Results: Of the 206 children with learning disabilities, 136 (66%) were male and 70 (34%) were female. In the control group, 120 (58%) children were male, 86 (42%) were female. We determined a significant difference in the blood serum zinc levels of the children with learning disabilities and the healthy control group (p=0.00). However, there was no significant difference in vitamin B12 levels (p=0.12). Conclusion: In our study, we found that the zinc levels of children with learning disabilities were significantly low compared to the zinc levels of the normal children of the same age. It was determined that there...

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“…Maternal iodine deficiency, even if mild, has also been associated with disorders of auditory processing in human offspring (Azizi et al, 1995;Hynes et al, 2013), and in rodents, early postnatal iodine deficiency and hypothyroidism resulted in decreased dendritic branching in the visual and auditory cortex (Dussault and Ruel, 1987). Maternal and neonatal zinc deficiency has also been associated in multiple studies with abnormal development of brain regions that play critical roles in processing sensory information (Hagmeyer et al, 2014), and with neurosensory disorders in children (Prasad, 1996). Although maternal and perinatal zinc deficiency has more classically been associated with deficits in offspring learning and memory and social behavior (Golub et al, 1995;Hagmeyer et al, 2014), the brain areas rich in zinc-containing glutamatergic neurons (cerebral cortex and limbic structures) also play a key role in sensory processing (Hagmeyer et al, 2014).…”

Section: Contextualizing Neonatal Biometric Parameters and Behavioralmentioning

confidence: 99%

Significant Effects of Maternal Diet During Pregnancy on the Murine Fetal Brain Transcriptome and Offspring Behavior

et al. 2019

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Background: Maternal over-and undernutrition in pregnancy plays a critical role in fetal brain development and function. The effects of different maternal diet compositions on intrauterine programing of the fetal brain is a lesser-explored area. The goal of this study was to investigate the impact of two chowmaternal diets on fetal brain gene expression signatures, fetal/neonatal growth, and neonatal and adult behavior in a mouse model. Methods: Throughout pregnancy and lactation, female C57Bl/6J mice were fed one of two standard, commercially available chow diets (pellet versus powder). The powdered chow diet was relatively deficient in micronutrients and enriched for carbohydrates and n-3 long-chain polyunsaturated fatty acids compared to the pelleted chow. RNA was extracted from embryonic day 15.5 forebrains and hybridized to whole genome expression microarrays (N = 5/maternal diet group). Functional analyses of significantly differentially expressed fetal brain genes were performed using Ingenuity Pathways Analysis and Gene Set Enrichment Analysis. Neonatal behavior was assessed using a validated scale (N = 62 pellet-exposed and 31 powder-exposed). Hippocampal learning, locomotor behavior, and motor coordination were assessed in a subset of adults using fear conditioning, open field testing, and Rotarod tests (N = 16 pellet-exposed, 14 powder-exposed). Results: Comparing powdered to pelleted chow diets, neither maternal weight trajectory in pregnancy nor embryo size differed. Maternal powdered chow diet was associated with 1647 differentially expressed fetal brain genes. Functional analyses identified significant upregulation of canonical pathways and upstream regulators involved in cell cycle regulation, synaptic plasticity, and sensory nervous system development in the fetal brain, and significant downregulation of pathways related to cell and embryo death. Pathways related to DNA damage response, brain immune response, amino acid and fatty acid transport, and dopaminergic signaling were significantly dysregulated. Powdered chow-exposed neonates were significantly longer but not heavier than pelleted chow-exposed counterparts. On neonatal behavioral

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Behavioral impairments in animal models for zinc deficiency

Cited by 71 publications

References 163 publications

The pharmacological perturbation of brain zinc impairs BDNF-related signalling and the cognitive performances of young mice

The pharmacological perturbation of brain zinc impairs BDNF-related signalling and the cognitive performances of young mice

Zinc and Vitamin B12 Levels in Children with Learning Disabilities

Significant Effects of Maternal Diet During Pregnancy on the Murine Fetal Brain Transcriptome and Offspring Behavior

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