Behavioral Impairment in Adult Rats Following Acute Zinc Deficiency

Caldwell, Donald F.; Oberleas, Donald; Clancy, John; As, Prasad

doi:10.3181/00379727-133-34703

Cited by 70 publications

(12 citation statements)

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“…The connection between zinc and picolinic acid is an interesting one. Zinc is absolutely essential for cognitive development and continuing cognitive function, as studies with rodents and Rhesus monkeys have indicated that zinc deficiency results in severe cognitive deficits, particularly in spatial working memory [53,54]. Similar results have been observed in humans, with zinc-deficient subjects displaying ataxia, depression, hallucinations, and deficiencies in memory [55][56][57].…”

Section: Discussionmentioning

confidence: 58%

Effects of Pre- and Postnatal Exposure to Chromium Picolinate or Picolinic Acid on Neurological Development in CD-1 Mice

Bailey

Boohaker

Jernigan

et al. 2008

Biol Trace Elem Res

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Chromium picolinate, Cr(pic)3, a popular dietary supplement marketed as an aid in fat loss and lean muscle gain, has also been suggested as a therapy for women with gestational diabetes. The current study investigated the effects of maternal exposure to Cr(pic)3 and picolinic acid during gestation and lactation on neurological development of the offspring. Mated female CD-1 mice were fed diets from implantation through weaning that were either untreated or that contained Cr(pic)3 (200 mg kg(-1) day(-1)) or picolinic acid (174 mg kg(-1) day(-1)). A comprehensive battery of postnatal tests was administered, including a modified Fox battery, straight-channel swim, open-field activity, and odor-discrimination tests. Pups exposed to picolinic acid tended to weigh less than either control or Cr(pic)3-exposed pups, although the differences were not significant. Offspring of picolinic acid-treated dams also appeared to display impaired learning ability, diminished olfactory orientation ability, and decreased forelimb grip strength, although the differences among the treatment groups were not significant. The results indicate that there were no significant effects on the offspring with regard to neurological development from supplementation of the dams with either Cr(pic)3 or picolinic acid.

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Section: Discussionmentioning

confidence: 58%

Effects of Pre- and Postnatal Exposure to Chromium Picolinate or Picolinic Acid on Neurological Development in CD-1 Mice

Bailey

Boohaker

Jernigan

et al. 2008

Biol Trace Elem Res

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“…Zinc has several neurobiological roles such as modulation of glutamate receptors [20,21] and dopamine transporter functioning [22,23]. Behavioral alterations are associated with zinc deficiency in rodents [24,25]. It is also a critical component for DNA transcription (zinc-finger motif).…”

Section: Introductionmentioning

confidence: 99%

Globus pallidus: a target brain region for divalent metal accumulation associated with dietary iron deficiency

Erikson

Syversen

Steinnes

et al. 2004

The Journal of Nutritional Biochemistry

109

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“…We suggest that zinc deficiency may contribute to this phenomenon. In this light, it is of interest that Caldwell et al [2] have reported that zinc deficiency early in the life of the rat will impair its behavioral development in a manner not unlike protein deficiency.…”

Section: Discussionmentioning

confidence: 99%

Zinc Deficiency: Effect on Brain of the Suckling Rat

1972

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ExtractThe effect of zinc deficiency on the brain of the suckling rat was studied by feeding a zinc-deficient (Zn~) diet to dams from parturition and measuring the in vivo uptake of 3 H-thymidine by brain DNA and the 35S uptake by brain protein as well as the brain lipid composition of their pups. These results were compared with similar data obtained on pups nursed by pair-fed (PF) and ad libitum-ied control dams which had been given zinc in addition to the diet.The specific activities (SA) of DNA and protein were decreased in the brains and livers of the pups nursed by the zinc-deficient dams compared with pups nursed by dams pair-fed with the zinc-deficient dams and hence semistarved ( Zinc deficiency has thus been shown to impair DNA and protein synthesis in brain of the suckling rat as it has previously been shown to do in other tissues including liver and epiphyseal plate.

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Behavioral Impairment in Adult Rats Following Acute Zinc Deficiency

Cited by 70 publications

References 0 publications

Effects of Pre- and Postnatal Exposure to Chromium Picolinate or Picolinic Acid on Neurological Development in CD-1 Mice

Effects of Pre- and Postnatal Exposure to Chromium Picolinate or Picolinic Acid on Neurological Development in CD-1 Mice

Globus pallidus: a target brain region for divalent metal accumulation associated with dietary iron deficiency

Zinc Deficiency: Effect on Brain of the Suckling Rat

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