Behavioral Impact of Long-Term Chronic Implantation of Neural Recording Devices in the Rhesus Macaque

Kyle, Colin T.; Permenter, Michele R.; Vogt, Julie; Rapp, Peter R.; Barnes, Carol A.

doi:10.1111/ner.12794

Cited by 6 publications

(3 citation statements)

References 26 publications

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“…Acclimation and familiarization to the apparatus at the beginning of testing included offering the monkey food rewards in the test tray, as well as the opportunity to displace objects and plaques covering food wells in order to obtain reward. Behavioral data from some of the monkeys reported as part of this population have appeared in previous publications (e.g., Dumitriu et al, 2010;Hara et al, 2012a;Kyle et al, 2019;Long et al, 2020;Motley et al, 2018;O'Donnell et al, 1999;Shamy et al, 2011Shamy et al, , 2006.…”

Section: Subjectsmentioning

confidence: 99%

Neuropsychology of cognitive aging in rhesus monkeys

Baxter

Roberts

et al. 2023

Preprint

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Aged rhesus monkeys, like aged humans, show declines in cognitive function. We present cognitive test data from a large sample of male and female rhesus monkeys, 34 young (3.5-13.6 years) and 71 aged (19.9-32.5 years of age at the start of cognitive testing). Monkeys were tested on spatiotemporal working memory (delayed response), visual recognition memory (delayed nonmatching-to-sample), and stimulus-reward association learning (object discrimination), tasks with an extensive evidence base in nonhuman primate neuropsychology. On average, aged monkeys performed worse than young on all three tasks. Acquisition of delayed response and delayed nonmatching-to-sample was more variable in aged monkeys than in young. Performance scores on delayed nonmatching-to-sample and object discrimination were associated with each other, but neither was associated with performance on delayed response. Sex and chronological age were not reliable predictors of individual differences in cognitive outcome among the aged monkeys. These data establish population norms for cognitive tests in young and aged rhesus monkeys in the largest sample reported to date. They also illustrate independence of cognitive aging in task domains dependent on the prefrontal cortex and medial temporal lobe.

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Section: Subjectsmentioning

confidence: 99%

Neuropsychology of cognitive aging in rhesus monkeys

Baxter

Roberts

et al. 2023

Preprint

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“…For our studies, we adapted a well-characterized single-unit recording method, using arrays of individually adjustable tetrodes, allowing micrometer-level resolution in electrode placement. This method is well established in several species, including rodents 27 and non-human primates, 28 and allows long-term recordings from virtually any brain structure.…”

Section: Introductionmentioning

confidence: 99%

Deep brain electrophysiology in freely moving sheep

Perentos¹,

Krstulovic²,

Morton³

2022

Current Biology

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“…This method is well established in several other species including rodents (e.g. (Nguyen et al, 2009) and non-human primates (Kyle et al, 2019) , and allows long-term recordings from virtually any brain structure.…”

Section: Introductionmentioning

confidence: 99%

Scaling up to meet new challenges of brain and behaviour through deep brain electrophysiology in freely moving sheep

Perentos

Krstulovic

Morton

2021

Preprint

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While rodents are arguably the easiest animals to use for studying brain function, relying on them as model species for translational research comes with its own sets of limitations. Here, we propose sheep as a practical large animal species for in vivo brain function studies performed in naturalistic settings. To demonstrate their experimental usefulness, we performed proof-of-principle deep brain electrophysiological recording experiments from unrestrained sheep. Recordings were made from cortex and hippocampus both whilst sheep performed goal-directed behaviours (two-choice discrimination tasks), and across states of vigilance that included natural sleep. Hippocampal and cortical oscillatory rhythms were consistent with those seen in rodents and non-human primates, and included cortical alpha oscillations during immobility, hippocampal theta oscillations (5-6Hz) during locomotion and hippocampal sharp wave ripple oscillations (~150 Hz) during immobility. Moreover, we found clear examples of neurons whose activity was modulated by task, speed of locomotion, spatial position, reward and vigilance states. Recordings were conducted over a period of many months. Due to the exceptional stability of individual electrodes we were able to record from some neurons continuously for more than 1 month. Together these experiments demonstrate that sheep are an excellent experimental animal model to use in longitudinal electrophysiological and imaging studies, particularly those requiring a large brained mammal, large scale recordings across distributed neuronal networks, experimentation outside the confounds of the traditional laboratory, or all the above concomitantly.

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Behavioral Impact of Long-Term Chronic Implantation of Neural Recording Devices in the Rhesus Macaque

Abstract: Our results suggest that chronic implants did not produce significant impairments on DNMS performance.

Cited by 6 publications

References 26 publications

Neuropsychology of cognitive aging in rhesus monkeys

Neuropsychology of cognitive aging in rhesus monkeys

Deep brain electrophysiology in freely moving sheep

Scaling up to meet new challenges of brain and behaviour through deep brain electrophysiology in freely moving sheep

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