Behavioral Functioning and Quality of Life in South African Children Living with HIV on Antiretroviral Therapy

Shiau, Stephanie; Evans, Henry Ridgely; Strehlau, Renate; Shen, Yanhan; Burke, Megan; Liberty, Afaaf; Coovadia, Ashraf; Abrams, Elaine J.; Yin, Michael T.; Violari, Avy; Kuhn, Louise; Arpadi, Stephen M.

doi:10.1016/j.jpeds.2020.07.057

Cited by 6 publications

(9 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These results were all consistent with the ndings in the general population aged 12-18 years in the previous studies [28]. In previous studies investigating HIV-infected children, one study reported males were more likely to suffer from emotional symptoms [17], and no gender differences in peer problems were found in a study conducted in Africa [11]. The gender difference in BEDs for HIV-infected children has implications in pediatric HIV care, in which care providers must pay attention to the unique needs of male and female children and offer speci c trainings and coping skills to children with BEDs.…”

Section: Discussionsupporting

confidence: 91%

“…Behavioral and emotional di culties (BEDs) refer to a variety of behavioral and emotional abnormalities that occur in children before the age of 18 and predominantly manifest as anxiety, fear, depression, hyperactivity, impulsivity, and disobedience [9]. Previous studies reported that HIV-infected children were more likely to suffer from BEDs than their HIVnegative peers [10,11]. The reasons included the physical and neurological effects of HIV infection on behavior, emotion, and cognition as well as social and emotional effects due to various stressors HIVinfected children often face, which were associated with HIV infection and treatment [11,12].…”

Section: Introductionmentioning

confidence: 99%

“…Previous studies reported that HIV-infected children were more likely to suffer from BEDs than their HIVnegative peers [10,11]. The reasons included the physical and neurological effects of HIV infection on behavior, emotion, and cognition as well as social and emotional effects due to various stressors HIVinfected children often face, which were associated with HIV infection and treatment [11,12]. Some social challenges faced by HIV-infected children included poverty, HIV stigma, relationship di culty related to HIV disclosure, and the school system's inability to meet their needs [13].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Behavioral and Emotional Difficulties and HIV Treatment Outcomes among HIV-Infected Children in Rural Southwest China

Zhou

Tang

Lü

et al. 2023

Preprint

View full text Add to dashboard Cite

Background Previous studies have not clearly demonstrated the impact of behavioral and emotional problems (BEDs) on treatment outcomes among HIV-infected children on antiretroviral therapy (ART). This study aimed to describe the prevalence of BEDs among this population and identify the factors associated with HIV treatment outcomes. Methods This cross-sectional study was conducted in Guangxi, China, between July and August 2021. HIV-infected children answered questionnaires about BEDs, physical health, social support, and whether they have missed doses in the past month. BEDs were assessed using the Chinese version of the self-reported Strengths and Difficulties Questionnaire (SDQ-C). Univariate and multivariate logistic regression models were used to identify factors that were associated with missed doses in the past month and virological failure. Results The study sample was 325 HIV-infected children. HIV-infected children had a higher proportion of abnormal scores on SDQ-C total difficulties compared to their peers in the general population (16.9 vs 10.0%; P = 0.002). An abnormal SDQ-C total difficulties score (AOR = 2.06, 95%CI: 1.10–3.88) and infrequency of receiving assistance and support from parents over the past 3 months (AOR = 1.85, 95%CI: 1.12–3.06) were significantly associated with missed doses in the past month. Between the ages of 14–17 years (AOR = 2.66, 95% CI: 1.37–5.16), female (AOR = 2.21, 95% CI: 1.20–4.08), and suboptimal adherence (AOR = 2.45, 95% CI: 1.32–4.57) were significantly associated with virological failure. Conclusions Children’s mental health plays a role in HIV treatment outcomes. Psychological interventions should be promoted in pediatric HIV care clinics to improve children’s mental health status and HIV treatment outcomes.

show abstract

Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Behavioral and Emotional Difficulties and HIV Treatment Outcomes among HIV-Infected Children in Rural Southwest China

Zhou

Tang

Lü

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…Subjects included in this analysis were a subset of participants from the Childhood HAART Alterations in Normal Growth, Genes, and aGing Evaluation Study (CHANGES) cohort, a longitudinal study conducted at Rahima Moosa Mother and Child Hospital and Chris Hani Baragwanath Hospital in Johannesburg, South Africa. Details of recruitment have been previously published [ 11 , 12 ]. Enrollment occurred between March 2014 and May 2016.…”

Section: Methodsmentioning

confidence: 99%

Comparison of quantitative ultrasonography and dual X-ray absorptiometry for bone status assessment in South African children living with HIV

Roberts

Shen²,

Strehlau³

et al. 2022

PLoS ONE

Self Cite

View full text Add to dashboard Cite

Children living with HIV (CLHIV) have decreased bone mineral content (BMC) and density (BMD), increasing risk for fracture and future osteoporosis. While DXA is the gold-standard for bone assessments, it lacks availability in resource-constrained settings (RCS). Quantitative ultrasound (QUS) offers an alternative owing to its portability, low cost, ease of handling, and lack of ionizing radiation. While QUS has detected reduced bone quality in CLHIV, the relationship between QUS and DXA in this population remains unexplored. At baseline and 12 months, BMC and BMD of the whole body, lumbar spine, and radius were measured by DXA in a longitudinal cohort of CLHIV in Johannesburg, South Africa. Calcaneal speed of sound (SOS) and broadband ultrasound attenuation (BUA) and radius SOS were obtained by QUS, and calcaneal stiffness index (SI) was calculated. Spearman correlations, with and without HIV stratification, were performed between QUS and DXA measurements at each visit and for absolute difference in measurements between visits. At baseline and 12-months, calcaneal BUA and SI displayed strong positive correlations with DXA, with only modest correlations between radial QUS and DXA at baseline. Longitudinal measures of QUS did not correlate with DXA. At both baseline and 12-months, individuals with DXA whole-body BMD z-score < -1 displayed significantly lower calcaneal BUA and SI. Cross-sectionally, calcaneal QUS correlates strongly with whole body DXA and may represent a viable diagnostic alternative in RCS. Longitudinally, the two methods do not correlate well, possibly reflecting that each method assesses distinct aspects of bone architecture.

show abstract

“…HEU children had an increased risk of having psychiatric disorders compared to HUU children [ 12 ]. Further, previous studies reported that HIV-infected children were more likely to suffer from BEDs than their HIV-negative peers [ 14 , 15 ]. The reasons included the physical and neurological effects of HIV infection on behavior, emotion, and cognition as well as social and emotional effects due to various stressors HIV-infected children often face, which were associated with HIV infection and treatment [ 15 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

Behavioral and emotional difficulties and HIV treatment outcomes among HIV-infected children in rural southwestern China

Zhou

Tang

Lü

et al. 2023

Child Adolesc Psychiatry Ment Health

View full text Add to dashboard Cite

Background Previous studies have not clearly demonstrated the impact of behavioral and emotional problems (BEDs) on treatment outcomes among HIV-infected children on antiretroviral therapy (ART). This study aimed to describe the prevalence of BEDs among this population and identify the factors associated with HIV treatment outcomes. Methods This cross-sectional study was conducted in Guangxi, China, between July and August 2021. HIV-infected children answered questionnaires about BEDs, physical health, social support, and whether they have missed doses in the past month. BEDs were assessed using the Chinese version of the self-reported Strengths and Difficulties Questionnaire (SDQ-C). The self-reported survey data were linked to participants’ HIV care information that was obtained from the national surveillance database. Univariate and multivariate logistic regression models were used to identify factors that were associated with missed doses in the past month and virological failure. Results The study sample was 325 HIV-infected children. HIV-infected children had a higher proportion of abnormal scores on SDQ-C total difficulties compared to their peers in the general population (16.9 vs 10.0%; P = 0.002). An abnormal SDQ-C total difficulties score (AOR = 2.06, 95%CI: 1.10–3.88) and infrequency of receiving assistance and support from parents over the past 3 months (AOR = 1.85, 95%CI: 1.12–3.06) were significantly associated with missed doses in the past month. Between the ages of 14–17 years (AOR = 2.66, 95% CI: 1.37–5.16), female (AOR = 2.21, 95% CI: 1.20–4.08), and suboptimal adherence (AOR = 2.45, 95% CI: 1.32–4.57) were significantly associated with virological failure. Conclusions Children’s mental health plays a role in HIV treatment outcomes. Psychological interventions should be promoted in pediatric HIV care clinics to improve children’s mental health status and HIV treatment outcomes.

show abstract

Behavioral Functioning and Quality of Life in South African Children Living with HIV on Antiretroviral Therapy

Cited by 6 publications

References 43 publications

Behavioral and Emotional Difficulties and HIV Treatment Outcomes among HIV-Infected Children in Rural Southwest China

Behavioral and Emotional Difficulties and HIV Treatment Outcomes among HIV-Infected Children in Rural Southwest China

Comparison of quantitative ultrasonography and dual X-ray absorptiometry for bone status assessment in South African children living with HIV

Behavioral and emotional difficulties and HIV treatment outcomes among HIV-infected children in rural southwestern China

Contact Info

Product

Resources

About