Behavioral Findings during Recovery after Experimental Stroke in Monkeys-Assessment with Modified Hand Performance Test-

Fukushima, Junko; Kasahara, Satoshi; Asaka, Tadayoshi; Saitô, Hiroshi; Yamanaka, Masanori

doi:10.1589/jpts.19.33

Cited by 4 publications

(4 citation statements)

References 22 publications

(35 reference statements)

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“…The first explanation proposes that the high number of trials performed in the modified Klu¨ver board task has increased the probability that subtle changes may still be statistically significant. The second explanation is consistent with the negative effect associated with the increase of well depth on the recovery of precision grip following injury (Fukushima et al, 2007), as the wells of the modified Klu¨ver board are deeper than the wells of the modified Brinkman board.…”

Section: Behavioral Resultssupporting

confidence: 64%

Role of primary motor cortex in the control of manual dexterity assessed via sequential bilateral lesion in the adult macaque monkey: A case study

et al. 2017

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Abstract-From a case study, we describe the impact of unilateral lesion of the hand area in the primary motor cortex (M1) on manual dexterity and the role of the intact contralesional M1 in long-term functional recovery. An adult macaque monkey performed two manual dexterity tasks: (i) ''modified Brinkman board" task, assessed simple precision grip versus complex precision grip, the latter involved a hand postural adjustment; (ii) ''modified Klü ver board" task, assessed movements ranging from power grip to precision grip, pre-shaping and grasping. Two consecutive unilateral M1 lesions targeted the hand area of each hemisphere, the second lesion was performed after stable, though incomplete, functional recovery from the primary lesion. Following each lesion, the manual dexterity of the contralesional hand was affected in a comparable manner, effects being progressively more deleterious from power grip to simple and then complex precision grips. Both tasks yielded consistent data, namely that the secondary M1 lesion did not have a significant impact on the recovered performance from the primary M1 lesion, which took place 5 months earlier. In conclusion, the intact contralesional M1 did not play a major role in the long-term functional recovery from a primary M1 lesion targeted to the hand area. Ó

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Section: Behavioral Resultssupporting

confidence: 64%

Role of primary motor cortex in the control of manual dexterity assessed via sequential bilateral lesion in the adult macaque monkey: A case study

et al. 2017

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“…It is likely though that their well dimensions were more different than those used in the current study and therefore represent a greater degree of difficulty. This is supported by data from Fukushima et al (2007) that reported increasing latencies for retrieval of a food reward from wells of increasing depths in young animals. This study demonstrates that animals require 0.67 ± 0.27 s to retrieve a food reward from a well of 30 mm diameter and 10 mm depth but 2.16 ± 1.68 s to retrieve a food reward from a well of 30 mm diameter and 50 mm depth.…”

Section: Discussionsupporting

confidence: 61%

Assessment of motor function of the hand in aged rhesus monkeys

Moore

Killiany

Pessina

et al. 2010

Somatosensory & Motor Research

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In the elderly, intact motor functions of the upper extremity are critical for the completion of activities of daily living. Many studies have provided insight into age-related changes in motor function. However, the precise nature and extent of motor impairments of the upper extremity remains unclear. In the current study we have modified two tasks to assess hand/digit function in both young and aged rhesus monkeys. We tested monkeys from 9 to 26 years of age on these tasks to determine the level of fine motor performance across the adult age range. Compared to young monkeys (9-12 years of age), aged monkeys (15-26 years of age) were mildly impaired on fine motor control of the digits. These findings are consistent with previous studies that have found age-related impairment in fine motor function. However, the magnitude and extent of impairment in the current study does differ from previous findings and is likely due to methodological differences in the degree of task complexity.

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“…Observations of behavioral recovery might be important for future studies. The animals showed various CMPs 7 ) . For recovery, CMPs as abnormal patterns in acute hemiparesis should be suppressed 6 ) .…”

Section: Discussionmentioning

confidence: 97%

The role of compensatory movements patterns in spontaneous recovery after stroke

Lee

2015

J Phys Ther Sci

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[Purpose] Post-stroke motor recovery consists of both true recovery and compensatory movements. Although compensatory movements are learned more quickly early after stroke, the role of compensatory movement patterns in functional recovery is controversial. We investigated the role of compensatory movement patterns in the long-term functional motor recovery after stroke. [Subjects and Methods] Male Wistar rats were subjected to photothrombotic infarction to induce motor and sensorimotor cortex lesions. The rats were given task-specific training. Behavior tests and analyses of compensatory movement patterns (head lift, limb withdrawal impairment, phantom grasps, and pellet chasing) during the single-pellet reaching test were performed 2, 7, 14, 21, 28, and 35 days post stroke. [Results] Successful retrieval during the single-pellet reaching test was significantly correlated with compensatory movement patterns in stroke groups. Motor cortex stroke showed significant correlation in limb withdrawal impairment and pellet chasing. But, sensorimotor cortex stroke was significant correlation in pellet chasing. [Conclusion] The data suggest that compensatory movements after stroke are correlated with spontaneous recovery. Since some compensatory movement patterns are detrimental to functional recovery, the correct timing of training and control of compensatory movement patterns might be important.

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Behavioral Findings during Recovery after Experimental Stroke in Monkeys-Assessment with Modified Hand Performance Test-

Cited by 4 publications

References 22 publications

Role of primary motor cortex in the control of manual dexterity assessed via sequential bilateral lesion in the adult macaque monkey: A case study

Role of primary motor cortex in the control of manual dexterity assessed via sequential bilateral lesion in the adult macaque monkey: A case study

Assessment of motor function of the hand in aged rhesus monkeys

The role of compensatory movements patterns in spontaneous recovery after stroke

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