Behavioral evidence for memory replay of video episodes in the macaque

Zuo, Shuzhen; Wang, Lei; Shin, Jung Han; Cai, Yudian; Zhang, Boqiang; Lee, Sang Wan; Appiah, Kofi; Zhou, Yong-Di; Kwok, Sze Chai

doi:10.7554/elife.54519

Cited by 15 publications

(15 citation statements)

References 54 publications

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“…In future work, micro-stimulation by electrical or targeted pharmacological intervention would be instrumental for a detailed elucidation of the complex cognitive roles carried out by the primate dorsomedial posterior parietal neurons. Before this study, monkey J and monkey M participated in a temporal order judgment behavioral experiment (Wang et al, 2020;Zuo et al, 2020). Monkey G was trained on fixation and saccadic tasks and participated in several oculomotor studies while neuronal activities were recorded from right medial temporal (MT) and medial superior temporal (MST) areas using single-tetrode tungsten electrodes in a different study.…”

Section: Discussionmentioning

confidence: 99%

Mixed selectivity coding of content-temporal detail by dorsomedial posterior parietal neurons

Wang

Zhou

Zeng

et al. 2022

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The dorsomedial posterior parietal cortex is part of a higher-cognition network implicated in elaborate processes underpinning memory formation, recollection, episodes reconstruction, and temporal processing. Neural coding for complex episodic processing is however largely undocumented. Here we revealed a set of neural codes of 'neuroethogram' in the primate parietal cortex. Analyzing neural responses in macaque dmPPC to naturalistic videos, we discovered several groups of neurons that are sensitive to categories of ethogram-items and to low-level sensory features. The amount of information coded within these multiplex representations in turn increases our trained classifier decodability for different video-types. We further discovered that the processing of category and feature information by these neurons is sustained by accumulation of temporal information over a long timescale, corroborating its role at the apex of the cortical hierarchy of temporal receptive windows. Taken altogether, these neural findings explain how dorsomedial PPC weaves fabrics of ongoing experiences together in real-time and realize a multiplex representation of an organism's past. The high dimensionality of neural representations should motivate us to shift the focus of attention from pure selectivity neurons to mixed selectivity neurons, especially in increasingly complex naturalistic task designs.

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Section: Discussionmentioning

confidence: 99%

Mixed selectivity coding of content-temporal detail by dorsomedial posterior parietal neurons

Wang

Zhou

Zeng

et al. 2022

Preprint

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“…We used temporal order judgement as our mnemonic task 70 . Monkeys initiated each memory trial by touching a red rectangle in the centre of the screen, and following a 4-s video clip and a variable delay duration (1-6 s), two frames extracted from the clip were displayed on opposite sides of the screen.…”

Section: Memory Taskmentioning

confidence: 99%

Time-sensitive Prefrontal Involvement in Associating Confidence With Task Performance Illustrates Metacognitive Introspection in Monkeys

Cai¹,

Jin²,

Zhai³

et al. 2022

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Metacognition refers to the ability to be aware of one’s own cognition. Ample evidence indicates that metacognition in the human primate is highly dissociable from cognition, specialized across domains, and subserved by distinct neural substrates. However, these aspects remain relatively understudied in macaque monkeys. In the present study, we investigated the functionality of macaque metacognition by combining a confidence proxy, hierarchical Bayesian meta-d′ computational modelling, and a single-pulse transcranial magnetic stimulation technique. We found that Brodmann area 46d (BA46d) played a critical role in supporting metacognition independent of task performance; we also found that the critical role in of this region in meta-calculation was time-sensitive. Additionally, we report that macaque metacognition is highly domain-specific with respect to memory and perception decisions. These findings carry implications for our understanding of metacognitive introspection within the primate lineage.

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“…Complex stimuli pose serious practical challenges to analyze. Manual annotation is effortful and time consuming, whereas crowd-sourcing effort ( Wang et al, 2020 ; Zuo et al, 2020 ) still might not capture the wide range of perceptual dynamics embedded in the stimuli. Recent progresses in machine learning algorithms have however automated the process of rapidly an-notating multi-modal stimuli.…”

Section: Existent Localizersmentioning

confidence: 99%

Common functional localizers to enhance NHP & cross-species neuroscience imaging research

et al. 2021

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Functional localizers are invaluable as they can help define regions of interest, provide cross-study comparisons, and most importantly, allow for the aggregation and meta-analyses of data across studies and laboratories. To achieve these goals within the non-human primate (NHP) imaging community, there is a pressing need for the use of standardized and validated localizers that can be readily implemented across different groups. The goal of this paper is to provide an overview of the value of localizer protocols to imaging research and we describe a number of commonly used or novel localizers within NHPs, and keys to implement them across studies. As has been shown with the aggregation of resting-state imaging data in the original PRIME-DE submissions, we believe that the field is ready to apply the same initiative for task-based functional localizers in NHP imaging. By coming together to collect large datasets across research group, implementing the same functional localizers, and sharing the localizers and data via PRIME-DE, it is now possible to fully test their robustness, selectivity and specificity. To do this, we reviewed a number of common localizers and we created a repository of well-established localizer that are easily accessible and implemented through the PRIME-RE platform.

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Behavioral evidence for memory replay of video episodes in the macaque

Cited by 15 publications

References 54 publications

Mixed selectivity coding of content-temporal detail by dorsomedial posterior parietal neurons

Mixed selectivity coding of content-temporal detail by dorsomedial posterior parietal neurons

Time-sensitive Prefrontal Involvement in Associating Confidence With Task Performance Illustrates Metacognitive Introspection in Monkeys

Common functional localizers to enhance NHP & cross-species neuroscience imaging research

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