Behavioral Effects of Some Psychopharmacological Agents

Cook, Leonard; Weidley, E. F.

doi:10.1111/j.1749-6632.1957.tb40763.x

Cited by 390 publications

(92 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Activity was assessed each night by the number of revolutions of the treadwheel, using a cross-over design to eliminate differences between cages and wheels. Black rats were trained to avoid a 7 s electric shock by escaping to a pole during a 7 s buzzer warning (Cook & Weidley, 1957). The effect of each drug treatment was assessed as the score from ten trials, compared with its pre-drug score.…”

Section: Methodsmentioning

confidence: 99%

Effects of intraventricular 2,4,5‐trihydroxyphenylethylamine (6‐hydroxydopamine) on rat behaviour and brain catecholamine metabolism

Laverty

Taylor

1970

British J Pharmacology

View full text Add to dashboard Cite

Summary1. 6-Hydroxydopamine (200 jug injected intraventricularly) caused depletion of noradrenaline from all regions of rat brain within 2 h after injection but depletion of dopamine in the brain was observed only from 2 days after injection. Both catecholamines remained depleted for more than 32 days. 2. Rats treated with intraventricular 6-hydroxydopamine were sedated and lethargic, with reduced spontaneous and exploratory activity, for periods of up to 8 days after injection. Conditioned avoidance responding was abolished or reduced for a similar period. 3. Intraventricular 6-hydroxydopamine caused a prolonged reduction in the amount of labelled catecholamines in store 4 h following an intraventricular injection of 3H-dopamine. During the first 6 h after 6-hydroxydopamine injection, there was a marked increase in neutral and acid metabolites from the labelled catecholamines. 4. A comparison of the behavioural and biochemical effects of intraventricular 6-hydroxydopamine and reserpine suggests that both drugs affect catecholamine storage mechanisms but by different mechanisms. It was not possible from these experiments to correlate behavioural changes with either catecholamine storage or metabolism.

show abstract

Section: Methodsmentioning

confidence: 99%

Effects of intraventricular 2,4,5‐trihydroxyphenylethylamine (6‐hydroxydopamine) on rat behaviour and brain catecholamine metabolism

Laverty

Taylor

1970

British J Pharmacology

View full text Add to dashboard Cite

show abstract

“…Conditioned avoidance response was studied in rats by using Cook's pole climbing apparatus 22 , manufactured by Techno, Lucknow.…”

Section: Methodsmentioning

confidence: 99%

Study of interaction of nifedipine with haloperidol on conditioned avoidance response and catalepsy in rats

Chandel

Phadke²,

Goyal

2012

Int J Basic Clin Pharmacol

View full text Add to dashboard Cite

Background: To study the interaction of calcium channel blocker (Nifedipine) with Antipsychotic drug (Haloperidol) on Conditioned avoidance Response and catalepsy in Rats. Methods: Every group consisted of 10 healthy albino rats of either sex. Different groups received Nifedipine (5, 10 & 20 mg/kg, i.p.), Haloperidol (ED50 -0.2mg/kg for CAR & 0.4mg/kg for catalepsy) alone and combined doses of both drugs. The Antipsychotic effect of drugs was measured by Conditioned avoidance response (CAR) using Cook’s Pole climbing apparatus and Adverse drug effect (Extra pyramidal syndrome) was measured by Catalepsy. Results: 5 mg/kg i.p. of Nifedipine inhibited CAR in 50 % of Rats (compared to control, p<0.001). 10mg/kg i.p. of Nifedipine inhibited CAR in 60% of Rats (p<0.001) & 20 mg/kg i.p. inhibited CAR in 70% of Rats (p<0.001). When Nifedipine (5 mg/kg i.p) was combined with Haloperidol ED50-0.2mg/kg the CAR was inhibited in 70% of the rats (p<0.01) and after combining Nifedipine (10mg/kg) with Haloperidol ED50-0.2mg/kg the CAR was inhibited in 80% Rats (p<0.001). Nifedipine at the dose of 5 mg/kg and 10 mg/kg (i.p.) did not induce catalepsy in the rats at any testing time interval. At 20 mg/kg i.p., it produced catalepsy in 2 rats at half hour and in 4 rats at 1 hour and 2 hour testing interval each (p<0.01). In the dose of 5, 10 and 20 mg/kg, pretreatment with Nifedipine significantly increased Haloperidol induced cataleptic scores at all testing intervals (p<0.05). Conclusions: Nifedipine blocked CAR. Its higher doses induced catalepsy and it is synergistic with haloperidol in blockade of CAR and catalepsy. [Int J Basic Clin Pharmacol 2012; 1(3.000): 178-183

show abstract

“…Hughes & Kopman (1960) found unimpaired escape responses but significantly suppressed avoidance responses subsequent to the administration of I and 2 mg/kg IP of CPZ while nearly total suppression of all responses occurred at 5 mg/kg IP. It should be noted that this effect has been demonstrated over a variety of escape behaviors including fence-jumping and wheel-turning (Verhave et ai, 1958), pole-climbing (Cook & Weidley, 1957), leg-flexion (Domino, Karoly, & Walker, 1963), and lever-pressing (Ht!ise & Boff, 1962).…”

mentioning

confidence: 99%