Behavioral effects of progestin in the brain

Barfield, Ronald J.; Glaser, Jeffrey H.; Rubin, Beverly S.; Etgen, Anne M.

doi:10.1016/0306-4530(84)90002-7

Cited by 32 publications

(15 citation statements)

References 58 publications

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“…However, since the latency to feeding (10-15 min) was similar after either ivt or local injection of NPY in the paraventricular nucleus, it is more likely that a complex interaction, possibly involving other neuronal systems, may underlie the action of NPY. On the other hand, evidence suggests that NPY neurons innervate the medial preoptic area and ventromedial nucleus (25)(26)(27)(28), sites known to mediate the male and female sexual behaviors, (48,49). Further, sequential treatment of ovariectomized rats with estrogen plus progesterone effected decreases in NPY immunoreactivity in the preoptic area at a time when sexual behavior is maximal, suggesting that the effects of NPY on female sexual behavior may be mediated via an action in this area of the brain (50).…”

Section: Discussionmentioning

confidence: 99%

Neuropeptide Y Stimulates Feeding but Inhibits Sexual Behavior in Rats*

Clark

Kalra

1997

Obesity Research

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The effects of neuropeptide Y (NPY), a tyrosine-rich peptide found in the rat brain, on feeding and sexual behavior were studied in male and female rats. Intraventricular (ivt) injections of NPY during the final hours of the light period induced feeding in a dose-related manner. While the lowest dose tested (0.02 nM) was without effect, higher doses (0.12, 0.47, 2.3 nM) uniformly elicited feeding with a latency of about 15 min in male rats. With the most effective dose, 0.47 nM, the increased food intake was due to an increased local eating rate. In contrast, the pattern of feeding behavior after a related peptide, rat pancreatic polypeptide (rPP), was quite different and less impressive. During the first hour, only one ivt dose of rPP (0.45 nM) evoked an increase in food intake, due to an increased time spent eating. Further, the effects of NPY on food intake were greater during the nocturnal period. Interestingly, increased food intake in nocturnal tests (4 h) was due solely to augmented intake during the first 60 min after ivt administration.In mating tests, initiated 2 h after the onset of darkness and 10 min after ivt administration of peptide, all but the lowest dose of NPY (0.01 nM) drastically suppressed ejaculatory behavior. Most rats treated with higher doses of NPY (0.02, 0.12, or 0.47 nM) mounted and intromitted only a few times before the cessation of sexual activity, and elongated latencies to the initial mount and intromission were observed. In contrast to the dramatic NPY-induced suppression of ejaculatory behavior, rPP (0.11 and 0.45 nM) was without effect on copulatory behavior. To substantiate further that the impairment of sexual behavior seen in NPY-treated rats was not due to an attenuated sexual ability, an additional experiment was performed. Penile reflexes, including erection, were monitored 10 min after ivt injection of NPY (0.12 nM), rPP (0.11 nM), or saline. No effect of NPY or rPP was observed on the proportion of rats showing erection or latency to initial erection, or in the number of erections per test. In fact, a slight facilitation of penile dorsiflexion responses was seen after NPY. These findings suggest that NPY selectively depresses sexual motivation in the male rat.In ovariectomized female rats responding to estrogen plus progesterone with a good level of sexual receptivity (lordosis quotient > 70), ivt saline and 0.01 nM NPY were without effect on sexual behavior. However, higher doses of NPY (0.12 and 0.47 nM) promptly suppressed sexual behavior in tests initiated 10 min after treatment. A significant 50% decrement in receptivity and a virtual elimination of proceptive behavior were observed. Further, although a low level of mounting (one to five mounts in 15 min) was seen in both the saline (33% mounting) and the 0.01 nM NPY (38% mounting) treated groups, none was observed in animals treated with the higher NPY doses. These observations indicate that NPY may also suppress female sexual behavior.These studies demonstrate that NPY, a novel hypothalamic peptide, st...

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Section: Discussionmentioning

confidence: 99%

Neuropeptide Y Stimulates Feeding but Inhibits Sexual Behavior in Rats*

Clark

Kalra

1997

Obesity Research

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“…Rose and W.A. Gem, in prepa ration], The fact that the priming action of EB takes at least a day and the subsequent P effect takes from 30 min to seve ral hours [depending on the route of administration, 26] has typically been explained in terms of a hormone-receptor complex acting on genomically mediated neuronal protein synthesis [1,11]. Whether the P effects seen in the present studies are loo rapid to be explained in terms of this classi cal mechanism of steroid hormone action cannot yet be said with certainty.…”

Section: Origins O F Hormone Effects On Antidromically Invaded and Ormentioning

confidence: 99%

“…Several of these investigations have identified hor mone-induced changes in the responsiveness of neurons to stimuli which elicit species-typical, hormone-dependent behaviors [23, 41,42,44,46], These hormone effects have probable behavioral significance since they were observed for neurons lying in brainstem regions involved in the con trol of the behaviors in question. In golden hamsters, for example, a variety of changes in midbrain neuronal func tion result from the lordosis-inducing action of estradiol (E) and P. Recordings from hamsters in which lordosis was hormonally induced prior to anesthetization demonstrated selectively enhanced responsiveness to lumbosacral tactile stimuli [42], Similar sensory effects, in addition to marked 1 Supported by NIH grant NS 13748.…”

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confidence: 99%

Estrogen-Dependent and Estrogen-Independent Effects of Progesterone on the Electrophysiological Excitability of Dorsal Midbrain Neurons in Golden Hamsters

Havens

Rose

1988

Neuroendocrinology

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During the induction of lordosis responses in golden hamsters, the joint actions of estradiol (E) and progesterone (P) have been found to produce major changes in the activity levels, sensory responsiveness and movement-related firing of neurons in the dorsal midbrain, a region vital for lordosis in this species. The present study investigated the possibility that these effects of E and P on dorsal midbrain neurons might arise through changes in transsynaptic excitability or spike-generating processes. Single dorsal midbrain neurons were orthodromically or antidromically activated by ventromedial midbrain tegmental stimulation in ovariectomized, urethane-anesthetized hamsters before and after subcutaneous injection of P in propylene glycol vehicle. P injection produced two neurophysiological effects: (1) a strong depression of transsynaptic activation, and (2) in antidromically invaded neurons, a change in the amplitude (either an increase or decrease) of the soma-dendritic spike component. Both of these effects appeared rapidly (i.e. within 10–20 min) after P injection. The P effect on orthodromic neuronal excitability was contingent upon E priming of the hamsters, but, in contrast, the P effect on antidromic spike amplitude was not. Several features of these neurophysiological effects of P imply that the hormone may have been acting through nongenomic mechanisms, possibly involving receptors in neuronal membranes.

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“…Other studies (7,16) which showed that it is possible that eating patterns change in the week before menstrual cycle and affect glucose levels; that women often have increased appetites and cravings during the days leading up to menstruation " many women experience cravings for high-carbohydrate foods during the late luteal phase of their cycle", However these studies suggest that this cannot be the sole cause of premenstrual hyperglycemia.…”

Section: Discussionmentioning

confidence: 99%