During a period of illness with Phlebotomus fever, decrements in the performances of eight experimental subjects were found to be approximately 18% in average work efficiency (sustained performance) and 14% in average muscular output. Both aspects of performance had recovered completely four days after the day of peak illness. Analyses of 24 biomedical indices of infection were also computed, and the average biomedical response was found to have decreased approximately 26% during illness without recovery to normal levels at the end of the 15-day study.