Behavioral effects of flumazenil in the social conflict test in mice

Uhlı́řová, Leona; Sustkova-Fiserova, Magdalena; Kršiak, M

doi:10.1007/s00213-003-1583-y

Cited by 13 publications

(2 citation statements)

References 53 publications

(61 reference statements)

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“…Flumazenil is known for its varied behavioral effects. Positive allosteric modulatory (PAM) activity of flumazenil in vivo has been reported in tests of social conflict, which, on treatment increased locomotor activities of timid mice and reduced aggression in aggressive mice ( Uhlírová et al, 2004 ). Electrophysiological experiments highlight an increasingly complicated understanding of flumazenil activity in vivo , highlighting canonical and noncanonical mechanisms.…”

Section: Discussionmentioning

confidence: 99%

Altered Behavioral Responses Show GABA Sensitivity in Muscleblind-Like 2-Deficient Mice: Implications for CNS Symptoms in Myotonic Dystrophy

Edokpolor

Banerjee

McEachin

et al. 2022

eNeuro

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Section: Discussionmentioning

confidence: 99%

Altered Behavioral Responses Show GABA Sensitivity in Muscleblind-Like 2-Deficient Mice: Implications for CNS Symptoms in Myotonic Dystrophy

Edokpolor

Banerjee

McEachin

et al. 2022

eNeuro

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“…This unexpected effect might be due to a possible excitatory effect of flumazenil on iguanas; a similar effect occurs in mice. 38 Alternatively, a hyperalgesic effect might also be possible in iguanas, given that flumazenil was able to reverse the antihyperalgesic effect of midazolam in mice. 37 However, both of these possible effects should be explored further.…”

Section: Discussionmentioning

confidence: 99%

Use of Rodent Sedation Tests to Evaluate Midazolam and Flumazenil in Green Iguanas (Iguana iguana)

Bressan

Sobreira

Carregaro

2019

j am assoc lab anim sci

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This study aimed to evaluate the applicability of rodent behavioral tests to assess the effects of midazolam and flumazenil in green iguanas. Four tests commonly used to assess sedation in rodents—the open field test, forced swim test, behavioral scale, and traction test—were conducted in 10 juveniles iguanas. The animals received midazolam (2 mg/kg IM) or 0.9% NaCl (0.4 mL/kg IM), and the tests were conducted between 0 and 300 min thereafter. To verify the effects of midazolam and flumazenil, the most informative tests from the evaluation stage and the limb withdrawal latency time (LWLT) were used. All 10 iguanas were tested under 4 conditions, as follows: MS, midazolam (2 mg/kg IM), followed 30 min later by 0.9% NaCl (0.4 mL/kg IM); FS, flumazenil (0.05 mg/kg IM), followed by 0.9% NaCl (0.4 mL/kg IM) 30 min later; MF, midazolam (2 mg/ kg IM), followed by flumazenil (0.05 mg/kg IM) 30 min later; and CON, 0.9% NaCl (0.4 mL/kg IM). The behavioral scale and the forced swim test showed the best detection of the onset, peak effect, and the differences between the sedated and control iguanas, with testing done between 15 and 240 min after drug administration. The sedative effect of midazolam began at 15 min and persisted through 180 min when assessed on the behavioral scale and 240 min when assessed by the forced swim test; flumazenil administration reversed the sedative effect. An increase in the LWLT was observed in the midazolam treatment groups between 15 and 30 min after drug administration. Flumazenil decreased LWLT between 15 and 180 min in the FS and at 60 min in the MF. In conclusion, the best methods to assess sedation in iguanas were the behavioral scale and the forced swim test. A dose of 2 mg/kg of midazolam was effective at inducing sedation in these juvenile iguanas, and this effect could be reversed by flumazenil.

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Anti-conflict effects of benzodiazepines in rhesus monkeys: relationship with therapeutic doses in humans and role of GABAA receptors

et al. 2005

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Behavioral effects of flumazenil in the social conflict test in mice

Abstract: Flumazenil produced moderate anxiolytic-like behavioural changes and a slight anxiogenic-like effect. The present data might be reflecting antagonism of corresponding endogenous BZR ligands. However, these putative ligands seem to exert only modest modulatory influence.

Cited by 13 publications

References 53 publications

Altered Behavioral Responses Show GABA Sensitivity in Muscleblind-Like 2-Deficient Mice: Implications for CNS Symptoms in Myotonic Dystrophy

Altered Behavioral Responses Show GABA Sensitivity in Muscleblind-Like 2-Deficient Mice: Implications for CNS Symptoms in Myotonic Dystrophy

Use of Rodent Sedation Tests to Evaluate Midazolam and Flumazenil in Green Iguanas (Iguana iguana)

Anti-conflict effects of benzodiazepines in rhesus monkeys: relationship with therapeutic doses in humans and role of GABAA receptors

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