Behavioral Effects of Cocaine--Metabolic and Neurochemical Approach

Ho, Beng T.; Taylor, Dorothy; Estevez, Vicente; Englert, Leo F.; McKenna, Mary

doi:10.1007/978-1-4684-3087-5_12

Cited by 33 publications

(13 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The possibility that pharmacokinetic factors may underlie these observations has to be considered. Such a phenomenon may explain kindling to cocaine (Ho et al, 1977). Several of the above findings argue against this.…”

Section: Discussionmentioning

confidence: 92%

See 1 more Smart Citation

Acute and chronic effects of the benzodiazepine receptor ligand FG 7142: proconvulsant properties and kindling

Little

Nutt

Taylor

1984

British J Pharmacology

133

View full text Add to dashboard Cite

The effects of the acute and chronic administration of the ,B-carboline benzodiazepine receptor ligand, FG 7142 were studied in mice. 2 On acute administration FG7142 (at doses between 10 and 40mgkg-1) lowered seizure thresholds to infused pentylenetetrazol (PITZ) but showed an unusual dose-response curve in that higher doses had less effect. The duration of action was considerably longer than that of other 1-carbolines, such as ethyl-1-carboline-3-carboxylate (ICCE). 3 During repeated administration, doses of FG 7142 which were initially proconvulsant subsequently produced generalized seizures on average in 60% of animals after 12 once daily treatments. This seemed to be a form of chemical kindling. 4 The effects of different drug administration regimes were studied. Once daily dosage was shown to be the optimum for kindling production, and was therefore used for subsequent experiments. 5 Kindling lasted for at least one month after 12 single once daily doses of 40mg kg-(FG 7142). 6 The administration of the benzodiazepine antagonist Ro 15-1788 concurrent with FG 7142 prevented kindling. When Ro 15-1788 was given to kindled animals along with a challenge dose of FG 7142, it prevented the expression of kindled seizures. These data show that kindling is mediated via the benzodiazepine receptor.

show abstract

Section: Discussionmentioning

confidence: 92%

“…Such a phenomenon may explain kindling to cocaine (Ho et al, 1977). Several of the above findings argue against this.…”

Section: Chronic Treatmentmentioning

confidence: 92%

Acute and chronic effects of the benzodiazepine receptor ligand FG 7142: proconvulsant properties and kindling

Little

Nutt

Taylor

1984

British J Pharmacology

133

View full text Add to dashboard Cite

show abstract

“…In fact, the behavioral effects of cocaine are generally opposite to this and are accompanied by reduced turnover and synthesis of serotonin,165-167 Ho et al 168 found significant decreases in norepinephrine and 5-HT levels in certain brain areas after chronic cocaine, with negligible effects on monoamine metabolites. Friedman et al 165 found that acute cocaine decreased the accumulation of 5-HT after prior administration of an MAO inhibitor and also decreased 5-HIAA, suggesting a reduced 5-HT turnover after cocaine.…”

Section: Serotoninmentioning

confidence: 96%

Recent Advances in Pharmacological Research on Alcohol

Wozniak

Linnoila

1992

Recent Developments in Alcoholism

View full text Add to dashboard Cite

Abstract. Alcohol dependence is a major public health problem. Studies have shown that a person dependent on alcohol often coabuses other substances, such as cocaine. Cocaine is a powerful stimulant whereas ethanol is generally considered to be a depressant, with some stimulating properties. The subjective effects of these two substances in a dependent individual may often appear to be more similar than they are different. Animals also self-administer both substances. Basically, although both substances have anesthetic properties and both act to functionally increase catecholaminergic function, especially that of dopamine, there are some differences in their actions. Both alcohol and cocaine have various effects on several neurotransmitters and systems, which ultimately interact to produce the feeling of well-being avidly sought by many individuals today. This drive often eventually produces a dependence which has associated social and medical consequences. It seems likely that the neurochemical changes that ensue following abuse of these substances underlie the phenomena of dependence, tolerance, and subsequent withdrawal. The apparent similarities and differences between these two substances will be reviewed in this chapter.

show abstract

“…1932a, b;Gutierrez-Noriega. 1950;Gutierrez-Noriega and Zapata-Ortiz, 1944;Stripling and Ellinwood, 1977;Ho, 1977;Post and Kopanda, 1975;Mago, 1969;Segal and Mandell, 1974;Klawans and Margolin, 1975;Ellinwood and Kilbey, 1975;Ranje and Ungerstedt, 1974]; Kramer [1972] provides similar evi dence for man. The term 'kindling' is derived from a phe nomenon in which repetitive subthreshold stimulation of the limbic system is eventually associated with major motor seizures, and Post and Kopanda [1976] relate the 'kindling' model not only to pharmacological and behav ioural phenomena, but also as an explanation for the pro gressive development of some psychopathological behav iour in man.…”

Section: Drug Tolerancementioning

confidence: 97%

Drugs as Research Tools in Psychology: Experiments with Drugs in Personality Research

Eysenck¹

1983

Neuropsychobiology

View full text Add to dashboard Cite

It is suggested that psychotropic drugs act to shift a person’s behaviour on the three major dimensions of personality in one direction or another, in predictable ways, and that it is possible to create a taxonomy of psychotropic drugs according to these effects. The history of this concept is traced and many examples given to illustrate how drug action and personality theory interact, and how this interaction can be used to gain greater insight into both personality and drug action.

show abstract

Behavioral Effects of Cocaine--Metabolic and Neurochemical Approach

Cited by 33 publications

References 13 publications

Acute and chronic effects of the benzodiazepine receptor ligand FG 7142: proconvulsant properties and kindling

Acute and chronic effects of the benzodiazepine receptor ligand FG 7142: proconvulsant properties and kindling

Recent Advances in Pharmacological Research on Alcohol

Drugs as Research Tools in Psychology: Experiments with Drugs in Personality Research

Contact Info

Product

Resources

About