Behavioral effects of acute exposure to the insecticide fipronil

Terçariol, Paula Raquel Galbiati; Godinho, Antonio Francisco

doi:10.1016/j.pestbp.2010.12.007

Cited by 54 publications

(22 citation statements)

References 36 publications

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“…Earlier studies have reported that liver, kidney and brain are the target organs for toxic insults of fipronil (Badgujar et al, 2015;Terç ariol and Godinho, 2011), owing to the fact that these tissues are extremely perfused organs and receive high blood volumes. In fact, liver toxicity to fipronil has been reported in mice following subchronic and chronic exposures (De Oliveira et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

“…Jackson et al (2009) have suggested that the "no observed adverse effect level" (NOAEL) for acute oral dose of fipronil in rats is 2.5 mg/kg. Importantly, recent evidences have shown that fipronil may be a potent toxicant affecting non-target organisms, including environmental species populations and potentially humans (Le Faouder et al, 2007) and deleterious effects were observed on the early stages of the animal development (Udo et al, 2014;Badgujar et al, 2015;Terç ariol and Godinho, 2011). Although the fipronil's actions are blocking the gamma-aminobutyric acid (GABA)-ergic receptors and glutamate (Glu)-gated chloride channels (Narahashi et al, 2007;Zhao et al, 2005), concerningly, evidence has demonstrated that fipronil induces the releasing of reactive oxygen species, resulting in increased oxidative stress (Overmyer et al, 2007;Vidau et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

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Exposure to fipronil elevates systolic blood pressure and disturbs related biomarkers in plasma of rats

Chaguri

Godinho

Horta

et al. 2016

Environmental Toxicology and Pharmacology

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Recent reports show that fipronil affects non-target organisms, including environmental species populations and potentially humans. We aimed to examine if fipronil exposure affects the systolic blood pressure and related biomarkers. Thus, fipronil was orally administered to rats (30 mg/kg/day) during 15 days (Fipronil group) or physiological solution (Control group). While fipronil increased significantly the systolic blood pressure (158±13 mmHg), no significant changes were observed in Control group (127±3 mmHg). Significantly, higher levels of fipronil in plasma were observed in Fipronil group (0.46±0.09 μg/mL versus 0.17±0.11 μg/mL in Control group). Fipronil group showed lower weight gain compared with Control group. While fipronil resulted in higher concentrations of endothelin-1, reduced antioxidant capacity and lower levels of circulating matrix metalloproteinase 2 (MMP-2) and nitric oxide (NO) metabolites compared to Control group, no alteration was observed in serum biomarkers of renal and hepatic/biliary functional abilities. Therefore, this study suggests that fipronil causes hypertension and endothelin-1 plays a key role. Also, these findings suggest that reductions of both MMP-2 and NO may contribute with the elevation of systolic blood pressure observed with fipronil.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Exposure to fipronil elevates systolic blood pressure and disturbs related biomarkers in plasma of rats

Chaguri

Godinho

Horta

et al. 2016

Environmental Toxicology and Pharmacology

Self Cite

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“…The number of head dips and the duration of each head dip (seconds) were recorded for 5 min. One head dip was considered as an animal having both eyes into a hole [40]. The testers were kept blind to the treatment procedures to minimize observational bias.…”

Section: Exploratory Behaviormentioning

confidence: 99%

Commercial Formulation of Chlorpyrifos Alters Neurological Behaviors and Fertility

Kudavidanage

Dissanayake

Keerthirathna

et al. 2020

Biology

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Pesticides are known to result in toxic insult. We aimed to evaluate Judo 40, the commercial formulation of chlorpyrifos on the neurological activities, fertility, and hormone levels of male rats. Male Wistar rats were treated orally with 1 mL of 20 or 50 mg/kg Judo 40. The doses were administered four times, twice a day. Sexual and exploratory behavior indices, fertility indices, serum androgen levels, blood acetylcholinesterase (BChE) levels, and neurological and muscular effects were evaluated. Serum testosterone and luteinizing hormone were significantly reduced in the rats receiving 50 mg/kg Judo 40. A reduction in viable implantation sites and live pups born were evident in the female rats mated with the male rats treated with the highest dose. Similarly, in the rats treated with the highest dose of Judo 40, a significant reduction in plasma BChE enzyme was observed. According to the results, prolonged Judo 40 exposure can cause impairment of the neurological alterations and sex hormones leading to impaired fertility. Therefore, chemical handlers should be educated on protection and risk minimization.Biology 2020, 9, 49 2 of 15 environment, chemical formulations of CPFs such as Judo 40 will undergo evaporation, hydrolysis, oxidation, photolysis, and microbial metabolism [15]. Owing to active soil absorption and the low water dissolubility of CPFs, this can result in the contamination of percolated water, runoff water, and sediments [16], leading to a high accumulation of CPF residues, thus posing acute and chronic health risks to consumers [17].It has been documented that the occupational exposure of humans to pesticides, including CPFs, are high [18]. However, in developing countries, small-scale farmers are continuously exposed to pesticides through mixing, filling, and spraying using backpack sprinklers [19]. They are further at a high risk due to the limited usage of protective gear and lack of awareness on safety [20]. In Sri Lanka, farmers are inclined to use about 30%-40% higher quantities of chemical formulations of CPF than the dose levels recommended by the manufacturers [21]. Growing evidence also indicates that CPF exposure can result in fetal developmental problems, including issues with the weight and head circumference of newborn babies [22], and high incidences of prostate and lung cancers in adults [23]. Alvarez et al. [24] reported that the soil can recover up to 25 ppm of CPF and the percentage decrease with increasing of the initial concentration [25]. The use of commercial formulations of pesticides can aggravate the toxic effects more than use of the pure active ingredient [26].The active ingredient of Judo 40, CPF, is principally responsible for the accumulation of acetylcholine (ACh) as a result of inhibition of acetylcholinesterase (AChE) action in animal tissues, and is highly toxic to many animals including copepods, amphipods [27], fish [28], birds, and mammals [29]. It was reported that chronic exposure to 30 days of chronic doses (5 and 10 mg/kg) of CPF led to a decrease in spe...

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“…However, using this insecticide may lead to formation of toxic metabolites in the environment (Gunasekara et al, 2007), such as sulfone and desulfinyl, which are photodegradation products reported as toxic for insects, mammals, fishes, and birds (Das et al, 2006). In addition, it is also known that exposure to pesticides is neurotoxic to rodents and other mammals, including humans (Terçariol & Godinho, 2011) due to their wide commercial and domestic uses (Tingle et al, 2003).…”

Section: Bioacumulação De Inseticida Em Agaricus Subrufescensmentioning

confidence: 99%

Bioaccumulation of insecticide in Agaricus subrufescens

Carvalho¹,

Marques²,

Martos³

et al. 2014

Hortic. Bras.

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Agaricus subrufescens, known as Sun Mushroom, is a high-value mushroom because of its medicinal properties, used as nutraceutical food to stimulate the immune system and to prevent some diseases, including cancer. Mushrooms are generally characterized by their great ability to bioaccumulate heavy metals and other toxic substances from the mushroom compost. Sugarcane bagasse is a common raw material used in mushroom compost production for Agaricus subrufescens cultivation, whereas insecticides, such as fipronil, can be applied to combat several pests in sugarcane crops. For this reason, we aimed to assess mushroom yield and fipronil bioaccumulation in Sun Mushroom, regarding different concentrations added to the mushroom compost (0, 8, 16 and 32 mg kg -1 ) and casing layer (0, 2, 4 and 8 mg kg -1 ). Each experiment was arranged in a completely randomized design with four replicates. Regression analysis from mushroom production data was applied using SISVAR 5.1 program. Fipronil was quantified using gas-liquid chromatography (HP 6890) with thermionic detector (NPD). Mushroom yield was affected when fipronil was added, decreasing from 12% (compost with 0 mg kg -1 of fipronil) to 4.8% (compost with 32 mg kg -1 ). However, bioaccumulation was not detected. In contrast, insecticide bioaccumulation was detected when adding fipronil to casing layer, increasing from <0.01 mg kg -1 (casing layer with 2 mg kg -1 ) to 0.26 mg kg -1 (casing layer with 8 mg kg -1 ), however, mushroom yield was not affected.

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Behavioral effects of acute exposure to the insecticide fipronil

Cited by 54 publications

References 36 publications

Exposure to fipronil elevates systolic blood pressure and disturbs related biomarkers in plasma of rats

Exposure to fipronil elevates systolic blood pressure and disturbs related biomarkers in plasma of rats

Commercial Formulation of Chlorpyrifos Alters Neurological Behaviors and Fertility

Bioaccumulation of insecticide in Agaricus subrufescens

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