Behavioral effects following repeated exposure to hexachloronaphthalene in rats

The effects of hexachloronaphthalene on selected parameters of heme biosynthesis and systemic toxicity in female wistar rats after 90‐day oral exposure

“…This mixture was used in previous studies conducted in our department, its purity was 94.14% and it contained mainly PCN67 (81.17%). 5.85% accounted for heptachloronaphthalene, as was described earlier . The content of dioxins and furans, analyzed by isotope dilution HRGC/HRMS, was below 1 pg/mg.…”

The Effect of Prenatal Exposure on Disposition of Hexachloronaphthalene in Female Wistar Rats and Fetal Compartment

“…This demonstrates the high affinity of the analyzed compound to the nervous system and potential induction of neurotoxic effects. Similarly, neurotoxicity was confirmed by previous studies showing neurobehavioral effects [47] and changes in gamma-aminobutyric acid (GABA)-metabolizing enzymes in rat brains [48].…”

Sources of unintentionally produced polychlorinated naphthalenes

“…The commonly used numbering system for the 75 congeners, and their chlorine substitution positions on the naphthalene skeleton, are presented in Table 1. PCNs are toxic, persistent, lipophilic substances (Falandysz et al, 1997;Kilanowicz and SkrzypinskaGawrysiak, 2010;Kilanowicz et al, 2011Kilanowicz et al, , 2012. PCNs were selected as candidate persistent organic pollutants (POPs) in 2002 by the United Nations Economic Commission for Europe POP Protocol (Lerche et al, 2002), and PCNs have recently been proposed for inclusion in Annexes A, B, and/or C of the Stockholm Convention on POPs, signifying that activities for controlling PCN source emissions and reducing their environmental exposure may be obligatory in the near future.…”