Behavioral deficits due to prenatal exposure to cadmium chloride in CFY rat pups

Lehotzky, K; Ungváry, G; Polinák, Dezsö; Kiss, Anita

doi:10.1016/0892-0362(90)90130-5

Cited by 32 publications

(20 citation statements)

References 17 publications

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“…With respect to possible mechanisms, laboratory animal experiments have demonstrated that cadmium exposure can affect neurotransmitter function, electrophysiological parameters, and behavior [40-47]. Combined with the epidemiologic studies, these reports from experimental toxicology increase the public health concerns about cadmium exposure and neurocognition.…”

Section: Discussionmentioning

confidence: 99%

Associations between cadmium exposure and neurocognitive test scores in a cross-sectional study of US adults

et al. 2013

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BackgroundLow-level environmental cadmium exposure and neurotoxicity has not been well studied in adults. Our goal was to evaluate associations between neurocognitive exam scores and a biomarker of cumulative cadmium exposure among adults in the Third National Health and Nutrition Examination Survey (NHANES III).MethodsNHANES III is a nationally representative cross-sectional survey of the U.S. population conducted between 1988 and 1994. We analyzed data from a subset of participants, age 20–59, who participated in a computer-based neurocognitive evaluation. There were four outcome measures: the Simple Reaction Time Test (SRTT: visual motor speed), the Symbol Digit Substitution Test (SDST: attention/perception), the Serial Digit Learning Test (SDLT) trials-to-criterion, and the SDLT total-error-score (SDLT-tests: learning recall/short-term memory). We fit multivariable-adjusted models to estimate associations between urinary cadmium concentrations and test scores.Results5662 participants underwent neurocognitive screening, and 5572 (98%) of these had a urinary cadmium level available. Prior to multivariable-adjustment, higher urinary cadmium concentration was associated with worse performance in each of the 4 outcomes. After multivariable-adjustment most of these relationships were not significant, and age was the most influential variable in reducing the association magnitudes. However among never-smokers with no known occupational cadmium exposure the relationship between urinary cadmium and SDST score (attention/perception) was significant: a 1 μg/L increase in urinary cadmium corresponded to a 1.93% (95%CI: 0.05, 3.81) decrement in performance.ConclusionsThese results suggest that higher cumulative cadmium exposure in adults may be related to subtly decreased performance in tasks requiring attention and perception, particularly among those adults whose cadmium exposure is primarily though diet (no smoking or work based cadmium exposure). This association was observed among exposure levels that have been considered to be without adverse effects and these levels are common in U.S. adults. Thus further research into the potential neurocognitive effects of cadmium exposure is warranted. Because cumulative cadmium exposure may mediate some of the effects of age and smoking on cognition, adjusting for these variables may result in the underestimation of associations with cumulative cadmium exposure. Prospective studies that include never-smokers and non-occupationally exposed individuals are needed to clarify these issues.

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Section: Discussionmentioning

confidence: 99%

Associations between cadmium exposure and neurocognitive test scores in a cross-sectional study of US adults

et al. 2013

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“…As to the prenatal exposure to low levels of Cd, there is relatively little information on the teratogenic effects. Part of this information shows that prenatal exposure to Cd causes long-lasting behavioral and pharmacological alterations in the offspring at doses that have no overt toxic effects on the dams (Lehotzky et al, 1990).…”

Section: Introductionmentioning

confidence: 98%

Sensorimotor developmental delays and lower anxiety in rats prenatally exposed to cadmium

Minetti

Reale

2005

J. Appl. Toxicol.

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Pregnant rats were treated with 0.3 or 0.6 mg cadmium (CdCl2) kg(-1) injected subcutaneously on a daily basis from gestational day 7 to day 15 (organogenesis period). One control group was not injected and the other received saline. Offspring were tested for ontogeny of sensorimotor development and at 45 or 90 days of age for anxiety behavior. The study of sensorimotor development showed that gestational exposure to 0.6 mg Cd kg(-1) produced a delay in the development of the righting reflex and of the cliff aversion in the pups. No differences were observed in the development of the negative geotaxis, nor in the ages of eye and ear opening. Anxiety studies using an elevated plus maze showed a lower anxiety in all the offspring prenatally exposed to 0.6 mg Cd kg(-1) as these rats spent more time and entered the open arms more times compared with those of the other groups. The results demonstrate that exposure to low levels of Cd during organogenesis may modify some central nervous system functions.

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“…It is possible that other mechanisms are involved in the observed memory deficits. The neurotoxic properties of Cd are well known (Lehotzky et al, 1990). Méndez-Armenta et al (2001) reported that the hippocampus, a crucial structure in memory processes, was affected by Cd.…”

Section: Discussionmentioning

confidence: 98%

“…These effects were associated with dose and quantity of urinary excretion of Cd (Viaene et al, 2000). Cadmium exposure in experimental animals was shown to produce memory deficits (Lehotzky et al, 1990) that may be associated with disturbances of the cholinergic neurotransmission in brain (Das et al, 1999), involved in learning and memory processes (Coyle et al, 1983).…”

mentioning

confidence: 97%

The Influence of Intracerebral Streptozotocin and/or Cadmium on Memory Processes in Mice Exposed to Transient Cerebral Oligemia

Sałaga-Pylak

Pikuła

Wójtowicz-Chomicz

et al. 2010

Journal of Toxicology and Environmental Health, Part A

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The aim of the study was to examine the effects of simultaneous acute exposure to cadmium (Cd) and in the presence of streptozotozin (STZ) on the central nervous system (CNS) memory processes in mice subjected to transient brain ischemia. In order to obtain transient brain ischemia, operative occlusion of common carotid arteries for 30 min was performed. Cadmium chloride was administered intraperitoneally (ip) after the surgery at a single dose of 0.1 LD(50) (LD(50) = 14 mg/kg). Disturbances in glucose metabolism in the brain tissue were induced by bilateral intracerebral administration of STZ, a drug that inhibits the function of a neuronal insulin receptor. Long-term memory was evaluated by means of a step-through passive avoidance task. Spatial working memory expressed as spontaneous alternations was tested in the Y-maze test. Coexposure to brain oligemia and STZ on the CNS produced significant impairment of long-term memory processes in mice. An additional exposure to Cd exacerbated the deficits of these processes. These results indicate that brain oligemia, Cd, and altered glucose metabolism may aggravate adverse effects on memory.

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Behavioral deficits due to prenatal exposure to cadmium chloride in CFY rat pups

Cited by 32 publications

References 17 publications

Associations between cadmium exposure and neurocognitive test scores in a cross-sectional study of US adults

Associations between cadmium exposure and neurocognitive test scores in a cross-sectional study of US adults

Sensorimotor developmental delays and lower anxiety in rats prenatally exposed to cadmium

The Influence of Intracerebral Streptozotocin and/or Cadmium on Memory Processes in Mice Exposed to Transient Cerebral Oligemia

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