Behavioral deficits, abnormal corticosterone, and reduced prefrontal metabolites of adolescent rats subject to early life stress

Zhang, Jie; Abdallah, Chadi G.; Chen, Yaowen; Huang, Tianhua; Huang, Qingjun; Xu, Chongtao; Xiao, Yao; Liu, Yuzhen; Ding, Yan; Wu, Renhua

doi:10.1016/j.neulet.2013.04.035

Cited by 25 publications

(13 citation statements)

References 36 publications

(50 reference statements)

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“…Similar behaviour has also been reported in adult NH offspring (Pryce et al, 2001;Shalev & Kafkafi, 2002;Madruga et al, 2006). Further, exposure to LMS (3 h) or early deprivation may result in reduced reward behaviour such as reduced preferences for sweet solutions (Hui et al, 2011;Zhang et al, 2013a), although findings of no difference or increase have also been reported (Mourlon et al, 2010;Uchida et al, 2010;Oines et al, 2012;Zhang et al, 2013b). Since rats usually prefer drinking sweet solutions to water, the reduced preference for sucrose is interpreted as a loss of interest in pleasure, hence resembling the human state of anhedonia.…”

Section: Affective-like Behaviour In Animal Modelssupporting

confidence: 61%

Hypothermia after chronic mild stress exposure in rats with a history of postnatal maternal separations

Mrdalj¹,

Mattson²,

Murison³

et al. 2013

Chronobiology International

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The circadian system develops and changes in a gradual and programmed process over the lifespan. Early in life, maternal care represents an important zeitgeber and thus contributes to the development of circadian rhythmicity. Exposure to early life stress may affect circadian processes and induce a latent circadian disturbance evident after exposure to later life stress. Disturbance of the normal regulation of circadian rhythmicity is surmised to be an etiological factor in depression. We used postnatal maternal separation in rats to investigate how the early life environment might modify the circadian response to later life unpredictable and chronic stress. During postnatal days 2-14, male Wistar rats (n = 8 per group) were daily separated from their mothers for a period of either 180 min (long maternal separation; LMS) or 10 min (brief maternal separation; BMS). In adulthood, rats were exposed to chronic mild stress (CMS) for 4 weeks. Body temperature, locomotor activity and heart rate were measured and compared before and after CMS exposure. LMS offspring showed a delayed body temperature acrophase compared to BMS offspring. Otherwise, adult LMS and BMS offspring demonstrated similar diurnal rhythms of body temperature, locomotor activity and heart rate. Exposure to CMS provoked a stronger and longer lasting hypothermia in LMS rats than in BMS rats. The thermoregulatory response appears to be moderated by maternal care following reunion, an observation made in the LMS group only. The results show that early life stress (LMS) in an early developmental stage induced a thermoregulatory disturbance evident upon exposure to unpredictable adult life stressors.

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Section: Affective-like Behaviour In Animal Modelssupporting

confidence: 61%

Hypothermia after chronic mild stress exposure in rats with a history of postnatal maternal separations

Mrdalj¹,

Mattson²,

Murison³

et al. 2013

Chronobiology International

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“…Accordingly, many neuropsychiatric disorders are associated with abnormalities in the HPA axis, with chronically elevated cortisol and reduced sensitivity to GC [20], suggesting stress may contribute to their development. Experiments in rats have shown that rats exposed to early life stress show elevated GCs as adults [21]. Similar observations have been made in human subjects who show chronically elevated GCs and altered stress response long after a traumatic event [17].…”

supporting

confidence: 58%

Circadian Clock and Stress Interactions in the Molecular Biology of Psychiatric Disorders

Landgraf

McCarthy

Welsh

2014

Curr Psychiatry Rep

144

100

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Many psychiatric disorders are characterized by circadian rhythm abnormalities including disturbed sleep/wake cycles, changes in locomotor activity, and abnormal endocrine function. Animal models with mutations in circadian "clock genes" commonly show disturbances in reward processing, locomotor activity and novelty seeking behaviors, further supporting the idea of a connection between the circadian clock and psychiatric disorders. However, if circadian clock dysfunction is a common risk factor for multiple psychiatric disorders, it is unknown if and how these putative clock abnormalities could be expressed differently, and contribute to multiple, distinct phenotypes. One possible explanation is that the circadian clock modulates the biological responses to stressful environmental factors that vary with an individual's experience. It is known that the circadian clock and the stress response systems are closely related: Circadian clock genes regulate the physiological sensitivity to, and rhythmic release of glucocorticoids (GC). In turn, GCs have reciprocal effects on the clock. Since stressful life events or increased vulnerability to stress are risk factors for multiple psychiatric disorders including posttraumatic stress disorder (PTSD), attention deficit hyperactivity disorder (ADHD), bipolar disorder (BD), major depressive disorder (MDD), alcohol use disorder (AUD) and schizophrenia (SCZ), we propose that modulation of the stress response is a common mechanism by which circadian clock genes affect these illnesses. Presently, we review how molecular components of the circadian clock may contribute to these six psychiatric disorders, and present the hypothesis that modulation of the stress response may constitute a common mechanism by which the circadian clock affects multiple psychiatric disorders.

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“…Chronic stressors in early life result in permanent epigenetic, endocrine, neural, immune and inflammatory changes, constituting a relevant risk factor for several neuropsychiatric diseases in adult life (Xiong and Zhang, 2013 ; Zhang et al, 2013 ; Berens et al, 2017 ). Traumatic childhood experiences such as abuse, neglect and parental loss increase the incidence of psychiatric disorders, such as MD that boost to 59%–75% in adult life (Widom et al, 2007 ) and anxiety disorders that are 1.9–3.6-fold more common in people who experience early life stress (Fernandes and Osório, 2015 ).…”

Section: Discussionmentioning

confidence: 99%

A Comprehensive Overview on Stress Neurobiology: Basic Concepts and Clinical Implications

Godoy

Rossignoli

Pereira

et al. 2018

Front. Behav. Neurosci.

501

376

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Stress is recognized as an important issue in basic and clinical neuroscience research, based upon the founding historical studies by Walter Canon and Hans Selye in the past century, when the concept of stress emerged in a biological and adaptive perspective. A lot of research after that period has expanded the knowledge in the stress field. Since then, it was discovered that the response to stressful stimuli is elaborated and triggered by the, now known, stress system, which integrates a wide diversity of brain structures that, collectively, are able to detect events and interpret them as real or potential threats. However, different types of stressors engage different brain networks, requiring a fine-tuned functional neuroanatomical processing. This integration of information from the stressor itself may result in a rapid activation of the Sympathetic-Adreno-Medullar (SAM) axis and the Hypothalamus-Pituitary-Adrenal (HPA) axis, the two major components involved in the stress response. The complexity of the stress response is not restricted to neuroanatomy or to SAM and HPA axes mediators, but also diverge according to timing and duration of stressor exposure, as well as its short- and/or long-term consequences. The identification of neuronal circuits of stress, as well as their interaction with mediator molecules over time is critical, not only for understanding the physiological stress responses, but also to understand their implications on mental health.

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Behavioral deficits, abnormal corticosterone, and reduced prefrontal metabolites of adolescent rats subject to early life stress

Cited by 25 publications

References 36 publications

Hypothermia after chronic mild stress exposure in rats with a history of postnatal maternal separations

Hypothermia after chronic mild stress exposure in rats with a history of postnatal maternal separations

Circadian Clock and Stress Interactions in the Molecular Biology of Psychiatric Disorders

A Comprehensive Overview on Stress Neurobiology: Basic Concepts and Clinical Implications

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