Behavioral correlates of presynaptic events in the cholinergic neurotransmitter system

Russell, Roger W.

doi:10.1007/978-3-0348-9154-7_3

Cited by 1 publication

(1 citation statement)

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“…The possible side-effects of ChAT disrupters on the brain and nervous system may be of concern for clinical applications of ChAT-ligands. While early studies aiming to disrupt ChAT activity by inducing morphological lesions in a murine model resulted in a worsened performance in the radial maze test, recent studies using small molecule inhibitors of ChAT activity demonstrated no such disruption in spatial brain functions (Russell, 1988). The administration of BW813U (50 mg/kg bodyweight intraperitoneally) in rats did not impair their performance in the radial maze test (Meck, 2006; Wenk, Sweeney, Hughey, Carson, & Olton, 1986).…”

Section: Choline Acetyltransferase (Chat)mentioning

confidence: 99%

Acetylcholine signaling system in progression of lung cancers

Friedman

Richbart

Merritt

et al. 2019

Pharmacology & Therapeutics

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The neurotransmitter acetylcholine (ACh) acts as an autocrine growth factor for human lung cancer. Several lines of evidence show that lung cancer cells express all of the proteins required for the uptake of choline (choline transporter 1, choline transporter-like proteins) synthesis of ACh (choline acetyltransferase, carnitine acetyltransferase), transport of ACh (vesicular acetylcholine transport, OCTs, OCTNs) and degradation of ACh (acetylcholinesterase, butyrylcholinesterase). The released ACh binds back to nicotinic (nAChRs) and muscarinic receptors on lung cancer cells to accelerate their proliferation, migration and invasion. Out of all components of the cholinergic pathway, the nAChR-signaling has been studied the most intensely. The reason for this trend is due to genome-wide data studies showing that nicotinic receptor subtypes are involved in lung cancer risk, the relationship between cigarette smoke and lung cancer risk as well as the rising popularity of electronic cigarettes considered by many as a "safe" alternative to smoking. There are a small number of review articles which review the contribution of the other cholinergic proteins in the pathophysiology of lung cancer. The primary objective of this review article is to discuss the function of the acetylcholine-signaling proteins in the progression of lung cancer. The investigation of the role of cholinergic network in lung cancer will pave the way to novel molecular targets and drugs in this lethal malignancy.

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Section: Choline Acetyltransferase (Chat)mentioning

confidence: 99%