Behavioral correlates of denervation and reinnervation of the hippocampal formation of the rat: open field activity and cue utilization following bilateral entorhinal cortex lesions

Silymarin Attenuated the Amyloid β Plaque Burden and Improved Behavioral Abnormalities in an Alzheimer’s Disease Mouse Model

“…24,40) As shown in Fig. 5A, the silymarinadministered transgenic mice showed a significantly decreased number of arm entries as compared with the vehicle-treated APP mice.…”

Combined Damage to Entorhinal Cortex and Cholinergic Basal Forebrain Neurons, Two Early Neurodegenerative Features Accompanying Alzheimer's Disease: Effects on Locomotor Activity and Memory Functions in Rats

“…A last possibility to account for hyperactivity in the double-lesion group may be weakened septo-hippocampal cholinergic sprouting in EC + SAPO rats. Shortly after EC lesions, one generally observes hyperactivity which is compensated for over approximately 1 week (Lasher and Steward, 1981;Steward et al, 1977). This return to normal activity levels could be due to the EC lesion-induced septo-hippocampal cholinergic sprouting.…”

Astrocytes and microglial cells incorporate degenerating fibers following entorhinal lesion: A light, confocal, and electron microscopical study using a phagocytosis-dependent labeling technique

“…Following lesion, intrinsic, associational, and commissural fibers sprout in the denervated outer molecular layers of the fascia dentata, a process that shows a high degree of layer specificity (Lynch et al, 1972(Lynch et al, , 1973Matthews et al, 1976a,b;Steward and Messenheimer, 1978;Frotscher, 1991;Deller et al, 1995Deller et al, , 1996. This process of reactive synaptogenesis had been considered to reflect the capability of functional reorganization following brain injury (Myhrer, 1975;Loesche and Steward, 1977;Steward et al, 1977;Cotman and Nieto-Sampedro, 1985); however, longlasting transneuronal changes in the deafferentiated hippocampus conflict with this view (Nitsch, 1993;Diekmann et al, 1996). Lesion-induced anterograde degeneration in the molecular layer is accompanied by a rapid morphological change of ramified microglia to an amoeboid form in the zone of denervation as early as 1 day after EC lesion.…”