Behavioral correlates of acute bilateral symmetrical epileptogenic foci in monkey cerebral cortex

Marcus, Elliott M.; Watson, C. Wesley; Simon, Stuart A.

doi:10.1016/0006-8993(68)90241-2

Cited by 34 publications

(4 citation statements)

References 8 publications

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“…Thus, the mean number of stimulations required for Stage 4 seizure bilateralization after reaching Stage 3 was 36, which is significantly slower than the mean of 11 stimulations required in the nonbisected group (p < 0.05). The findings are consistent with previous reports of the CC being the major, if not the exclusive, pathway for transhemispheric propagation of seizure (Erickson, 1940;Kopeloff et al, 1950;Marcus and Watson, 1966;Marcus and Watson, 1968;Marcus et al, 1 9 6 8~;Marcus et al, 19686;Musgrave and Gloor, 1980;Mutani, 1977). Baboons with an intact AC showed AD propagation into the contralateral AM and HIPP, yet their seizures remained largely lateralized, while asymmetrical generalization occurred leading to hemiconvulsion showed evidence of a significant delay in the intrahemispheric ictal processes in all the animals.…”

Section: Primary Site Kindlingsupporting

confidence: 93%

Limbic Kindling in the Forebrain‐Bisected Photosensitive Baboon, Papio papio

Wada

Mizoguchi

1984

Epilepsia

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When forebrain-bisected photosensitive baboons, Papio papio, were kindled from the amygdala or hippocampus, bilateralization of convulsive seizure proved difficult, and the final stage of bisymmetrical and bisynchronous convulsive seizure unique to this species did not develop despite more than twice the number of kindling stimulations required for its development in nonbisected baboons. At the secondary site amygdala, convulsive seizure development was suppressed. Findings of the present and previous studies suggest that the corpus callosum plays: (a) a major, if not an exclusive, role in convulsive seizure bilateralization ; and (b) a critical role in the development of primarily generalized convulsive seizures unique to this epileptic baboon. Finally, in the absence of the corpus callosum (and the hippocampal commissure) the transhemisphere seizures suppressing effect generated by amygdaloid kindling appears to be mediated through the subcortical pathway which presumably exists in the brainstem.

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Section: Primary Site Kindlingsupporting

confidence: 93%

Limbic Kindling in the Forebrain‐Bisected Photosensitive Baboon, Papio papio

Wada

Mizoguchi

1984

Epilepsia

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“…The majority of motor and EEG phenomena observed in animals with unilateral foci are in accordance with data from the literature dealing with neocortical foci. 13,[15][16][17][18][19][20][21][22] On the other hand, the only study of behavioural correlates of bilateral foci was performed in monkeys by Marcus et al, 23 however detailed description of them is lacking. In our work, the semiology of interictal and ictal phenomena in both groups was basically identical--dominated by interictal myoclonias and simple partial motor seizures.…”

Section: Discussionmentioning

confidence: 99%

Motor correlates of models of secondary bilateral synchrony and multiple epileptic foci

Jiruška

Proks

Otáhal

et al. 2007

Seizure

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Bilateral synchronous epileptiform discharges registered in patients with partial epilepsies may be generated by different pathophysiological mechanisms. Differentiation between underlying mechanisms is often crucial for correct diagnosis and adequate treatment in clinical epileptology. The aim of this study was to model in rats two possible mechanisms--secondary bilateral sychrony and interaction between multiple epilepic foci. Furthermore, to describe in detail semiology, laterality and differences in motor phenomena. Secondary bilateral synchrony was modeled by unilateral topical application of bicuculline methiodide (BMI) over the sensorimotor cortex. Bilateral symmetric application of BMI was used as a model of multiple epileptic foci. Electrographic and behavioural phenomena were recorded for 1h following the application of BMI. Electroencephalogram in both groups was characterized by presence of bilateral synchronous discharges. Myoclonic and clonic seizures involving forelimb and head muscles represented the most common motor seizure pattern in both groups. Significant differences were found in the laterality of motor phenomena. Motor seizures in unilateral foci always started in the contralateral limbs whereas symmetrical foci exhibited bilateral independent onset of convulsions. Similar lateralization was observed in interictal motor phenomena (myoclonic jerks). An important influence of posture on epileptic motor phenomena was demonstrated. Active or passive changes in animal posture (verticalization to bipedal posture) caused conversion from unilateral myoclonic jerks or clonic seizures to bilaterally synchronous (generalized) motor phenomena in both groups.

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“…Both systemic estrogen administration (Logothetis and Harner, 1960;Woolley et al, 1960;Werboff and Corcoran, 1961;Woolley and Timiras, 1962;Werboff et al, 1963;Stitt and Kinnard, 1968;Terasawa and Timiras, 1968;Blackhan and Spencer, 1970) and local placement of estrogen on the cortex (Logothetis and Harner, 1960;Marcus et al, 1968;Mirsky et al, 1973) have resulted in increased susceptibility to generalized seizures. Both systemic estrogen administration (Logothetis and Harner, 1960;Woolley et al, 1960;Werboff and Corcoran, 1961;Woolley and Timiras, 1962;Werboff et al, 1963;Stitt and Kinnard, 1968;Terasawa and Timiras, 1968;Blackhan and Spencer, 1970) and local placement of estrogen on the cortex (Logothetis and Harner, 1960;Marcus et al, 1968;Mirsky et al, 1973) have resulted in increased susceptibility to generalized seizures.…”

Section: Discussionmentioning

confidence: 99%

“…Our results are somewhat surprising in view of prior studies in adult animals demonstrating a proconvulsant effect of estrogen. Both systemic estrogen administration (Logothetis and Harner, 1960;Woolley et al, 1960;Werboff and Corcoran, 1961;Woolley and Timiras, 1962;Werboff et al, 1963;Stitt and Kinnard, 1968;Terasawa and Timiras, 1968;Blackhan and Spencer, 1970) and local placement of estrogen on the cortex (Logothetis and Harner, 1960;Marcus et al, 1968;Mirsky et al, 1973) have resulted in increased susceptibility to generalized seizures.…”

Section: Discussionmentioning

confidence: 99%

Effect of Systemic Estrogen on Seizure Susceptibility in the Immature Animal

Schultz-Krohn¹,

Thompson²,

Holmes³

1986

Epilepsia

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Estrogens have previously been reported to be proconvulsants in adult animals. This study evaluated the effects of acute, high-dose estrogen administration on rate of kindling in immature rats. No significant differences in rate of kindling between the estrogen-treated rats and controls were noted. This study, using the kindling model, demonstrates that estradiol does not have a significant effect on the development of seizures in the immature animal.

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Behavioral correlates of acute bilateral symmetrical epileptogenic foci in monkey cerebral cortex

Cited by 34 publications

References 8 publications

Limbic Kindling in the Forebrain‐Bisected Photosensitive Baboon, Papio papio

Limbic Kindling in the Forebrain‐Bisected Photosensitive Baboon, Papio papio

Motor correlates of models of secondary bilateral synchrony and multiple epileptic foci

Effect of Systemic Estrogen on Seizure Susceptibility in the Immature Animal

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