Behavioral Consequences of Repeated Nicotine During Adolescence in Alcohol‐Preferring AA and Alcohol‐Avoiding ANA Rats

Kemppainen, Heidi; Hyytiä, Petri; Kiianmaa, Kalervo

doi:10.1111/j.1530-0277.2008.00838.x

Cited by 16 publications

(16 citation statements)

References 57 publications

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“…For example, Tsui et al (2001) demonstrated that nicotine during adolescence, using a similar preexposure preparation as the present study, enhanced the acquisition of alcohol consumption in adulthood. However, other studies have demonstrated that continuous nicotine delivered via mini-osmotic pumps during periadolescence does not alter voluntary alcohol consumption immediately subsequent to nicotine exposure (Smith et al , 2002), nor does nicotine preexposure during periadolescence alter alcohol consumption in alcohol-preferring (AA) rats (Kemppainen et al , 2009). Parametric differences (e.g., length of nicotine preexposure, dose of nicotine, route of administration, strain of rat) preclude any conclusions regarding the influence of alterations in the aversive effects of alcohol after periadolescent nicotine preexposure on alcohol consumption.…”

Section: Discussionmentioning

confidence: 99%

Exposure to nicotine during periadolescence or early adulthood alters aversive and physiological effects induced by ethanol

Rinker

Hutchison

Chen

et al. 2011

Pharmacology Biochemistry and Behavior

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The majority of smokers begin their habit during adolescence, which often precedes experimentation with alcohol. Interestingly, very little preclinical work has been done examining how exposure to nicotine during periadolescence impacts the affective properties of alcohol in adulthood. Understanding how periadolescent nicotine exposure influences the aversive effects of alcohol might help to explain why it becomes more acceptable to this preexposed population. Thus, Experiment 1 exposed male Sprague Dawley rats to either saline or nicotine (0.4 mg/kg, IP) from postnatal day 34 to 43 (periadolescence) and then examined changes in the aversive effects of alcohol (0, 0.56, 1.0 and 1.8 g/kg, IP) in adulthood using the conditioned taste aversion (CTA) design. Changes in blood alcohol concentration (BAC) as well as alcohol-induced hypothermia and locomotor suppression were also assessed. To determine if changes seen were specific to nicotine exposure during periadolescence, the procedures were replicated in adults (Experiment 2). Preexposure to nicotine during periadolescence attenuated the acquisition of the alcohol-induced CTAs (at 1.0 g/kg) and the hypothermic effects of alcohol (1.0 g/kg). Adult nicotine preexposure produced similar attenuation in alcohol's aversive (at 1.8 g/kg) and hypothermic (1.8 g/kg) effects. Neither adolescent nor adult nicotine preexposure altered BACs or alcohol-induced locomotor suppression. These results suggest that nicotine can alter the aversive and physiological effects of alcohol, regardless of the age at which exposure occurs, possibly increasing its overall reinforcing value and making it more likely to be consumed.

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Section: Discussionmentioning

confidence: 99%

Exposure to nicotine during periadolescence or early adulthood alters aversive and physiological effects induced by ethanol

Rinker

Hutchison

Chen

et al. 2011

Pharmacology Biochemistry and Behavior

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show abstract

“…Similar to our results, Kemppainen et al . 37 found no effect of adolescent nicotine pre-exposure on subsequent alcohol intake in adulthood. However, a challenge of nicotine given to rats with a history of nicotine exposure increased alcohol self-administration compared to nicotine-naïve controls 37 , suggesting that nicotine pre-treatment leads to sensitizing effects relevant to alcohol intake.…”

Section: Discussionmentioning

confidence: 69%

“…While several studies have shown that nicotine treatment acutely increases alcohol intake (e.g., refs 11, 12, 16 and 17) and alcohol relapse 12, 17 , only a few studies tested the effects of a repeated nicotine treatment on subsequent alcohol self-administration (e.g., refs 10 and 37). Similar to our results, Kemppainen et al .…”

Section: Discussionmentioning

confidence: 99%

Re-exposure to nicotine-associated context from adolescence enhances alcohol intake in adulthood

Zipori

Sadot-Sogrin

Goltseker

et al. 2017

Sci Rep

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Alcohol and nicotine are the two most commonly-abused substances and are often used together. Nicotine enhances alcohol-drinking behaviors in humans and in animals, and was suggested to enhance the reinforcing properties of other reinforcers. Here, we show that nicotine-associated environment, rather than nicotine itself, enhances alcohol intake in rats. Adolescent rats received repeated intermittent injections of nicotine (0.4 mg/kg, i.p., 5 injections, every 3rd day) or saline. The injection was paired with their home cage, or with the subsequent alcohol self-administration context. Rats were then trained to self-administer 20% alcohol. Nicotine given in the home cage did not alter subsequent alcohol intake. However, pairing nicotine with the operant chamber during adolescence led to a long-lasting increased alcohol self-administration in adulthood, compared to nicotine pre-treatment in other contexts. This effect persisted 3 months after nicotine cessation, in a relapse test after abstinence. Furthermore, re-exposure to the nicotine-associated context in adult rats led to a decrease in glial cell line-derived neurotrophic factor (Gdnf) mRNA expression in the ventral tegmental area, an effect that leads to increased alcohol consumption, as we have previously reported. Our findings suggest that retrieval of nicotine-associated contextual memories from adolescence may gate alcohol intake in adulthood, with a possible involvement of GDNF.

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“…In contrast, [23] observed that female adolescent mice (PND 35-41) exposed to nicotine showed increased bottle-drinking ethanol consumption on (PND [41][42][43][44]. The effects of nicotine exposure during adolescence on ethanol intake seem to depend on the treatment age, duration, strain, sex, and nicotine withdrawal period [23,40]. To our knowledge, this is the first study that has demonstrated increased operant saccharine self-administration while assessing the consequences of nicotine pretreatment during adolescence in later life.…”

Section: Discussionmentioning

confidence: 92%

Exposure to Nicotine in Adult, but not Adolescent, Rats Increases Alcohol Self-Administration in Adulthood

P¹,

Cruz²,

Carneiro-de-Oliveira³

et al. 2017

J Alcohol Drug Depend

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Among drugs of abuse, nicotine and alcohol are the most consumed in the world, and are often co-abused. Evidence has shown that nicotine enhances the consumption and subjective effects of ethanol. How nicotine increases alcohol consumption is an interesting question that is still left unanswered. We assessed whether repeated treatment with nicotine during adolescence or adulthood could increase operant alcohol selfadministration. Male adolescent and adult rats (postnatal day [PND] 28 and 60, respectively) were injected with nicotine (1.0 mg/kg, subcutaneously [s.c.], three times a day for 10 days). During this period, the control group received saline injections (0.1 ml/kg; s.c). On PND 72, adolescent and adult rats pretreated with nicotine were subjected to ethanol self-administration procedures. Alcohol oral self-administration patterns were evaluated using a progressive ratio schedule of reinforcement and 24-hour unlimited access to ethanol. Our results showed that nicotine pretreatment in adult rats increases the motivation for alcohol consumption. However, nicotine exposure during adolescence does not affect alcohol-consuming behaviors in adulthood.

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Behavioral Consequences of Repeated Nicotine During Adolescence in Alcohol‐Preferring AA and Alcohol‐Avoiding ANA Rats

Cited by 16 publications

References 57 publications

Exposure to nicotine during periadolescence or early adulthood alters aversive and physiological effects induced by ethanol

Exposure to nicotine during periadolescence or early adulthood alters aversive and physiological effects induced by ethanol

Re-exposure to nicotine-associated context from adolescence enhances alcohol intake in adulthood

Exposure to Nicotine in Adult, but not Adolescent, Rats Increases Alcohol Self-Administration in Adulthood

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