Behavioral characterization of morphine effects on motor activity in mice

Patti, Camilla L.; Frussa‐Filho, Roberto; Silva, Regina H.; Carvalho, Reinaldo de Amorim; Kameda, Sonia R.; Takatsu-Coleman, André L.; Cunha, J.L.S.; Abı́lio, Vanessa C.

doi:10.1016/j.pbb.2005.07.004

Cited by 72 publications

(71 citation statements)

References 46 publications

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“…Similar effect was shown by study of Peltier et al (1996) as discussing below. In contrast to cocaine, our results show morphine-induced decrease in locomotion which did not differ based on the prenatal exposure and is in agreement with many studies of others (Vezina and Stewart, 1987;Nazarian et al, 1999;Patti et al, 2005).…”

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confidence: 93%

Does Prenatal Methamphetamine Exposure Induce Cross-sensitization to Cocaine and Morphine in Adult Male Rats?

et al. 2012

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R e c e i ve d J a n u a r y 2 3 , 2 0 12 ; A c c e p t e d Ju n e 2 5 , 2 0 1 2 .Key words: Prenatal drug exposure -Methamphetamine -Cocaine -MorphineOpen field -Plantar test -Conditioned place preference -LocomotionNociception -Drug-seeking behavior Abstract:The aim of the present study was to examine the cross-sensitization induced by prenatal methamphetamine (MA) exposure to challenge dose of cocaine or morphine. Rat mothers received a daily injection of MA (5 mg/kg) or saline throughout the gestation period. Adult male offspring (prenatally MA-or saline-exposed) were divided to groups with challenge doses of saline (1 ml/kg), cocaine (5 mg/kg) or morphine (5 mg/kg). Behavior in unknown environment was examined in Laboras, nociception in Plantar test, and active drug-seeking behavior in conditioned place preference (CPP). Our data demonstrate that cocaine increased the exploratory activity in Laboras test in prenatally saline-exposed, but decreased it in prenatally MA-exposed rats. An analgesic effect of cocaine was demonstrated only by the tail withdrawal and it was independent of the prenatal drug exposure. CPP test showed that prenatal MA exposure induced rather tolerance than sensitization to cocaine. In contrast to cocaine effects, morphine decreased rearing activity in both, prenatally MA-exposed and saline-exposed rats, and locomotion only in prenatally MA-exposed rats in the Laboras. In the Plantar Prague Medical Report / Vol. 113 (2012) No. 3, p. 189-205 test, the results demonstrated that morphine had an analgesic effect in prenatally saline-exposed rats but this effect was suppressed in prenatally MA-exposed rats. In the CPP test morphine induced drug-seeking behavior, which however was not affected by prenatal drug exposure. Thus, our data demonstrate that there is a cross-effect between prenatal MA exposure and the challenge dose of other drug in adulthood, however drug-seeking behavior is not increased by prenatal MA exposure as we expected.

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Section: )supporting

confidence: 93%

Does Prenatal Methamphetamine Exposure Induce Cross-sensitization to Cocaine and Morphine in Adult Male Rats?

et al. 2012

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“…Therefore, this result seems not supporting the opioid involvement. However, it may also be explained by the strain variation among different mice as both stimulatory and depressive locomotor effects of morphine have been reported depending on the dose and the interval after the administration (Patti et al, 2005) and the strain of mice (Belknap et al, 1998;Patti et al, 2005).…”

Section: Discussionmentioning

confidence: 99%

Supersensitivity to Amphetamine in Protein Kinase-C Interacting Protein/HINT1 Knockout Mice

Barbier

Zapata

et al. 2007

Neuropsychopharmacol

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Protein kinase C interacting protein/histidine triad nucleotide binding protein 1 (PKCI/HINT1) is a member of the histidine triad protein family. Although this protein is widely expressed in the mammalian brain including mesocorticolimbic and mesostriatal regions, its physiological function in CNS remains unknown. Recent microarray studies reported decreased mRNA expression of PKCI/HINT1 in the frontal cortex of individuals with schizophrenia, suggesting the possible involvement of this protein in the pathophysiology of the disease. In view of the documented link between dopamine (DA) transmission and schizophrenia, the present study used behavioral and neurochemical approaches to examine the influence of constitutive PKCI/HINT1 deletion upon: (i) basal and amphetamine (AMPH)-evoked locomotor activity; (ii) DA dynamics in the dorsal striatum, and (iii) postsynaptic DA receptor function. PKCI/HINT1À/À (KO) mice displayed lower spontaneous locomotion relative to wild-type (WT) controls. Acute AMPH administration significantly increased locomotor activity in WT mice; nonetheless, the effect was enhanced in KO mice. Quantitative microdialysis studies revealed no alteration in basal DA dynamics in the striatum or nucleus accumbens of KO mice. The ability of acute AMPH to increase DA levels was unaltered indicating that function in presynaptic DA neurotransmission in these regions do not underlie the behavioral phenotype of KO mice. In contrast to WT mice, systemic administration of the direct-acting DA receptor agonist apomorphine (10 mg/kg) significantly increased locomotor activity in KO mice suggesting that postsynaptic DA function is altered in these animals. These results demonstrate an important role of PKCI/HINT1 in modulating the behavioral response to AMPH. Furthermore, they indicate that the absence of this protein may be associated with dysregulation of postsynaptic DA transmission.

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“…The behavioural effects of morphine have been studied extensively in mice and reported as producing locomotor hyperactivity when tested in automated activity assays (1, 2, 7) or a biphasic response in an observer quantified open-field assay with locomotor depression at low doses and locomotor activation at higher doses (8). A similar biphasic response to morphine was shown in an automated open-field assay (9) but the extent of this biphasic response varied with the mouse strain examined (10).…”

Section: Introductionmentioning

confidence: 94%

“…Furthermore, the morphine dose used and the data acquisition time point post-administration (8) have been found to be important variables in addition to mouse strain (10,11). Morphine exerts certain behavioural effects by stimulating μ-opioid receptors (1) and dopaminergic neurotransmission (12).…”

Section: Introductionmentioning

confidence: 99%

Behavioural and Anatomical Characterization of Mutant Mice With Targeted Deletion of D1 Dopamine Receptor^|^ndash;Expressing Cells: Response to Acute Morphine

et al. 2013

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Abstract. Considerable topographic overlap exists between brain opioidergic and dopaminergic neurons. Pharmacological blockade of the dopamine D 1 receptor (Drd1a) reverses several behavioural phenomena elicited by opioids. The present study examines the effects of morphine in adult mutant (MUT) mice expressing the attenuated diphtheria toxin-176 gene in Drd1a-expressing cells, a mutant line shown previously to undergo post-natal striatal atrophy and loss of Drd1a-expression. MUT and wild-type mice were assessed behaviourally following acute administration of 10 mg/kg morphine. Treatment with morphine reduced locomotion and rearing similarly in both genotypes but reduced total grooming only in MUT mice. Morphine-induced Straub tail and stillness were heightened in MUT mice. Chewing and sifting were decreased in MUT mice and these effects were not modified by morphine. Loss of striatal Drd1-positive cells and up-regulated D 2 -expression, as reflected in down-regulated D 1 -like and up-regulated D 2 -like binding, respectively, is not uniform along the cranio-caudal extent in this model but appears to be greater in the caudal striatum. Preferential caudal loss of μ-opioid-expression, a marker for the striosomal compartment, was seen. These data indicate that Drd1a-positive cell loss modifies the exploratory behavioural response elicited by morphine, unmasking novel morphine-induced MUT-specific behaviours and generating a hypersensitivity to morphine for others.

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Behavioral characterization of morphine effects on motor activity in mice

Cited by 72 publications

References 46 publications

Does Prenatal Methamphetamine Exposure Induce Cross-sensitization to Cocaine and Morphine in Adult Male Rats?

Does Prenatal Methamphetamine Exposure Induce Cross-sensitization to Cocaine and Morphine in Adult Male Rats?

Supersensitivity to Amphetamine in Protein Kinase-C Interacting Protein/HINT1 Knockout Mice

Behavioural and Anatomical Characterization of Mutant Mice With Targeted Deletion of D1 Dopamine Receptor^|^ndash;Expressing Cells: Response to Acute Morphine

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