Behavioral characteristics of the SAM-P/8 strain in Sidman active avoidance task

Ohta, Akira; Hirano, Toshitsugu; Yano, Hideo; Tanaka, Satoshi; Hosokawa, Masanori; Takeda, Takeshi

doi:10.1016/0006-8993(89)90421-6

Cited by 103 publications

(37 citation statements)

References 8 publications

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“…For our study, the total aging score of the MP-supplemented dietary group was significantly lower than was the case for the control groups for, separately, both male and female mice (pϽ0.05). Several reports indicated that the SAMP8 strain exhibited an agerelated deterioration in leaning and memory when challenged with various learning tests such as passive avoidance (29,30). Our results demonstrated that the MP supplement is associated with a reduction in the age-related deterioration of skin coarseness, hair loss, and lordokyphosis of spine as well as learning and memory ability in both male and female SAMP8 mice.…”

Section: Discussionsupporting

confidence: 58%

Effect of Monascus-Fermented Products on Learning and Memory in the SAMP8 Mice

Wang

Yang

et al. 2007

J Nutr Sci Vitaminol

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SummaryThe purpose of this study was to evaluate the impact of Monascus -fermented products (MP) as regards certain changes in behavior for SAMP8 mice. Both male and female SAMP8 mice were fed a 0.03% MP diet from 3 mo of age to 11 mo of age. The results indicated that the grading score of passive avoidance behavior was significantly lower in the MP diet groups than in the control diet groups in both male and female SAMP8 mice ( p Ͻ 0.05). The MP diet-augmented test-animal body weight, feed intake and feed efficiency did not differ significantly from the corresponding values for control mice. The MP diet-fed mouse group revealed significantly improved learning and memory as revealed by average escape-response testing score when comparing with control mice ( p Ͻ 0.05). Further, the level of serum triglyceride and total cholesterol for the MP-fed group were shown to be significantly lower than for the control group of SAMP8 mice at 11 mo of age. The test mice fed an MP diet appeared to be significantly lower in aging score than the control group ( p Ͻ 0.05). The MP diet-fed mouse group revealed significantly improved total antioxidation of liver. Subsequent to supplementation of SAMP8 mice diets with MP for a period of 8 mo, these MP-fed mice revealed significantly lower lipofuscin-cell numbers within the hippocampus ( p Ͻ 0.05). The results suggest that dietary supplementation with MP might improve both learning and memory behaviour, and retard the aging process for SAMP8 mice.

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Section: Discussionsupporting

confidence: 58%

Effect of Monascus-Fermented Products on Learning and Memory in the SAMP8 Mice

Wang

Yang

et al. 2007

J Nutr Sci Vitaminol

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“…In a murine model of accelerated senescence (senescence-accelerated mouse), severe senile amyloidosis is one of the most characteristic age-associated disorders (Higuchi et al 2004). Ohta et al (1989) and Flood & Morley (1993) have reported that the senescence-accelerated-prone 8 (SAMP8) mouse exhibits a remarkable age-related deterioration in its learning ability and memory. It is therefore an excellent Alzheimer's disease model for studying the pathological changes in the brain and deficits in cognitive ability.…”

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confidence: 99%

Beneficial effect of Toona sinensis Roemor on improving cognitive performance and brain degeneration in senescence-accelerated mice

et al. 2006

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The purpose of the present study was to examine the effects of Toona sinensis Roemor extracts on antioxidative activities, brain morphological changes and cognitive ability. In an in vitro study, the antioxidant capacities of water extracts from Toona sinensis Roemor leaf (TSL), root (TSR) and bark (TSB) were evaluated by an a,a-diphenyl-b-pricryl-hydrazyl radical-scavenging test. The results showed that the scavenging activities of all Toona sinensis Roemor extracts were over 80 % at a concentration of 0·625 mg/ml. In an in vivo study, 3-month-old male senescence-accelerated-prone 8 mice were used as the tested subjects and fed four different diets: casein diet or casein diet supplemented with 1 % TSL, TSR or TSB extract for 12 weeks. The results showed that the mice supplemented with Toona sinensis Roemor extracts demonstrated significantly less amyloid b-protein deposition and lower levels of thiobarbituric acid-reactive substances than the control group. All Toona sinensis Roemor diet groups also showed better active shuttle avoidance responses, and higher superoxide dismutase, catalase and glutathione peroxidase activities, than the control group. It can thus be concluded that supplementation with either TSL, TSR or TSB extract could not only reduce the incidence of ß-amyloid plaques, but also improve learning and memory ability in senescence-accelerated-prone 8 mice. This might be due to the beneficial effects of Toona sinensis Roemor extracts on promoting the antioxidative defence system. Free radical-mediated reactions and reactive oxygen species have been proposed to be the major contributors to the pathological processes of neurodegenerative diseases such as Alzheimer's and Parkinson's disease. Alzheimer's disease is accompanied by cognitive impairment as well as involving the pathological build-up of extracellular, vascular and parenchymal deposits of a 40 -42-amino peptide, amyloid b-protein. It has been demonstrated that oxidative damage increased both in the brains of individuals with Alzheimer's disease (Friedlich & Butcher, 1994;Smith et al. 1997;Montine et al. 1999) and in b-amyloid plaque-forming transgenic mouse models of Alzheimer's disease Pappolla et al. 1998;Smith et al. 1998), suggesting that an elevated level of amyloid b-protein is sufficient to stimulate oxidative damage. In an in vitro study, a direct application amyloid b-protein to neuronal cells increased the production of H 2 O 2 (Behl et al. 1994), leading to amyloid b-protein neurotoxicity, which could be prevented by the use of antioxidants (Behl et al. 1992;Goodman et al. 1994).The development of rodent models of Alzheimer's disease will elucidate some important aspects of the aetiology of the disease and the development of therapeutic methods. In a murine model of accelerated senescence (senescence-accelerated mouse), severe senile amyloidosis is one of the most characteristic age-associated disorders (Higuchi et al. 2004). Ohta et al. (1989) and Flood & Morley (1993) have reported that the senescence-accelerated-prone 8 (SAM...

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“…The indices of aging found in the SAMP8 mouse include a moderate to severe decline of activity, hair loss and lack of hair glossiness, skin coarseness, periopthalamic lesions, and increased lordokyphosis of the spine. In addition, the SAMP8 strain exhibits age-related deterioration in memory and learning (27,28) and, therefore, is thought to be a good model for aging.Consistent with other researchers (19,20), our laboratory previously demonstrated that free radical oxidative stress led to increased amounts of oxidized proteins in cortical synaptosomal membranes (1, 3-12), a result also seen in aged gerbils (1). Therefore, if free radicals were involved in aging, we hypothesized that SAMP8 age-accelerated mice should show evidence of cortical membrane protein oxidation.…”

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confidence: 99%

Free radical oxidation of brain proteins in accelerated senescence and its modulation by N -tert-butyl-α-phenylnitrone

Butterfield

Howard

Yatin

et al. 1997

Proc. Natl. Acad. Sci. U.S.A.

224

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According to the free radical theory of aging, reactive oxygen species cause oxidative damage, proposed to be an underlying factor of the aging process. In the current study, we have used electron paramagnetic resonance spin labeling, measurements of protein carbonyl content, an index of protein oxidation, and determination of the activity of glutamine synthetase (an oxidatively sensitive enzyme) to report that cortical synaptosomal membranes from the senescence accelerated-prone (SAMP8) mouse showed structural characteristics of free radical oxidative stress relative to the senescence accelerated-resistant (SAMR1) mouse. The SAMP8 mouse exhibited a decrease in the relevant EPR parameter consistent with oxidative stress (P < 0.002), a decreased glutamine synthetase activity (P < 0.05), and an increased protein carbonyl content (P < 0.01) compared with these parameters in the SAMR1 mouse. Further, because free radical trapping compounds have been demonstrated to extend maximum life span and improve cognition in SAMP8 mice, we investigated the protective nature of the known free radical scavenger, N-tert-butyl-␣-phenylnitrone (PBN), on the physical state of cortical synaptosomal membrane proteins. For 14 days, SAMR1 and SAMP8 mice were injected with 30 mg͞kg PBN while the controls were injected with the corresponding volume of saline. Characteristic of less oxidized systems, cortical synaptosomal membranes from the PBNinjected SAMP8 mouse exhibited a return toward normal values of the relevant EPR parameter [the M I ‫؍‬ ؉1 low-field weakly immobilized line͞M I ‫؍‬ ؉1 low-field strongly immobilized line (W͞S) ratio of a protein-specific spin label] (P < 0.001) compared with that from saline-injected SAMP8 mice. In SAMR1 mice, in contrast to SAMP8, there was no significant change in the conformation of membrane proteins or protein carbonyl content of cortical synaptosomal membranes from the PBN-injected and saline-injected SAMR1 mice, showing that PBN itself did not induce conformational changes in cortical synaptosomal membrane proteins. The results are discussed with reference to the use of free radical scavengers as potential anti-aging agents.Aging and age-related neurological disorders, especially Alzheimer disease and stroke, affect millions of people worldwide. Many hypotheses have been developed to explain aging and age-related neurodegenerative disorders. One of the most compelling, and one for which our laboratory has contributed extensively, is the role of free radical-induced oxidative stress in aging, stroke, Alzheimer disease, Parkinson disease, and Huntington disease (1-20). The free radical theory of normal aging proposes that the slow generation of oxygen free radicals, an unavoidable consequence of life in an aerobic environment, results in cumulative damage to critical cellular components, and eventually leads to age-related pathology (21). A consensus is emerging that free radical processes do play an important role in the etiology of many age-related disorders (10,11,16,17,22,23), althou...

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Behavioral characteristics of the SAM-P/8 strain in Sidman active avoidance task

Cited by 103 publications

References 8 publications

Effect of Monascus-Fermented Products on Learning and Memory in the SAMP8 Mice

Effect of Monascus-Fermented Products on Learning and Memory in the SAMP8 Mice

Beneficial effect of Toona sinensis Roemor on improving cognitive performance and brain degeneration in senescence-accelerated mice

Free radical oxidation of brain proteins in accelerated senescence and its modulation by N -tert-butyl-α-phenylnitrone

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