Behavioral changes in early ALS correlate with voxel-based morphometry and diffusion tensor imaging

Tsujimoto, Masashi; Senda, Joe; Ishihara, T.; Niimi, Yoshiki; Kawai, Yohei; Atsuta, Naoki; Watanabe, Haruo; Tanaka, Fumiaki; Naganawa, Shinji; Sobue, Gen

doi:10.1016/j.jns.2011.05.025

Cited by 81 publications

(62 citation statements)

References 34 publications

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“…We suggest that this pattern can be due to a subclinical impairment of the premotor cortical areas and the cortico-spinal tract in the FTD/SQSTM1 carriers group, since SQSTM1 is also a disease-causing ALS gene. In a VBM study of ALS with behavioral symptoms [26], the ALS patients with apathy, depression, and anxiety showed an atrophy profile very similar to that found in the present study after comparing the FTD/SQSTM1 carriers with Sporadic FTD, comprising premotor and motor areas and corticospinal tracts. These results reinforce the idea that there could be an important association between mutations in the SQSTM1 gene and the FTD-MND spectrum [9][10][11].…”

Section: Discussionsupporting

confidence: 84%

Neuroimaging Correlates of Frontotemporal Dementia Associated with SQSTM1 Mutations

Luis

Ortiz

Eudave

et al. 2016

JAD

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Abstract.Background: Frontotemporal lobar degeneration (FTLD) is a progressive dementia characterized by focal atrophy of frontal and/or temporal lobes caused by mutations in the gene coding for sequestosome 1 (SQSTM1), among other genes. Rare SQSTM1 gene mutations have been associated with Paget's disease of bone, amyotrophic lateral sclerosis, and, more recently, frontotemporal lobar degeneration (FTLD). Objective: The aim of the study was to determine whether a characteristic pattern of grey and white matter loss is associated with SQSTM1 dysfunction. Methods: We performed a voxel-based morphometry (VBM) study in FTD subjects carrying SQSTM1 pathogenic variants (FTD/SQSTM1 mutation carriers; n = 10), compared with FTD subjects not carrying SQSTM1 mutations (Sporadic FTD; n = 20) and healthy controls with no SQSTM1 mutations (HC/SQSTM1 noncarriers; n = 20). The groups were matched according to current age, disease duration, and gender. Results: After comparing FTD/SQSTM1 carriers with Sporadic FTD, a predominantly right cortical atrophy pattern was localized in the inferior frontal, medial orbitofrontal, precentral gyri, and the anterior insula. White matter atrophy was found in both medial and inferior frontal gyri, pallidum, and putamen. FTD/SQSTM1 carriers compared with HC/SQSTM1 noncarriers showed atrophy at frontal, temporal, and parietal lobes of both hemispheres whereas the MRI pattern found in Sporadic FTD compared with controls was frontal and left temporal lobe atrophy, extending toward parietal and occipital lobes of both hemispheres. Conclusions: These results suggest that fronto-orbito-insular regions including corticospinal projections as described in ALS are probably more susceptible to the damaging effect of SQSTM1 mutations delineating a specific gene-linked atrophy pattern.

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Section: Discussionsupporting

confidence: 84%

Neuroimaging Correlates of Frontotemporal Dementia Associated with SQSTM1 Mutations

Luis

Ortiz

Eudave

et al. 2016

JAD

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“…This has also been shown on the morphological level (Tsujimoto et al, 2011). Another pathophysiological pathway discussed in the pathogenesis of FTD is the progranulin pathway (Sleegers et al, 2010).…”

Section: Dementiamentioning

confidence: 69%

Amyotrophic Lateral Sclerosis: An Introduction to Treatment and Trials

Maurer¹

2012

Amyotrophic Lateral Sclerosis

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“…In the early stages of ALS, the severity of apathy is associated with the degeneration of the right hemisphere, especially in the anterior cingulate tract and right temporal white matter [30] . Additionally, social behavioral abnormalities, including apathy, disinhibition, eating disorders and aberrant motor behaviors, are correlated with tissue loss of the right hemisphere in AD patients [31] .…”

Section: Discussionmentioning

confidence: 99%

“…Right hemisphere dysfunction, structural lesions, or hypo-metabolism could cause delusions, and impaired ego boundaries, self-monitoring and familiarity to stimuli [32][33][34] , whereas dysfunction on the left hemisphere may cause unchecked false explanations to outer stimuli [35] . Furthermore, comprehension and expression are mainly operated by the right hemisphere [30] , which may explain why right hemisphere dysfunction might induce poor impulse control, childish behavior and poor modulated affect [31] . Therefore, we assumed that the right hemisphere, instead of left hemisphere, may play an important role in the BPSD.…”

Section: Discussionmentioning

confidence: 99%

An association between the location of white matter changes and the behavioral and psychological symptoms of dementia in Alzheimer's disease patients

Lin

Kao

et al. 2016

Transl. Neurosci. Clin.

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KEYWORDSAlzheimer's diseas; white matter changes; leukoaraiosis; behavioral and psychological symptoms of dementia Objective:The frontal lobe may be involved in circuits associated with depression, apathy, aggression, and other psychiatric symptoms. Although white matter changes (WMC) are related to the severity of behavioral and psychological symptoms of dementia (BPSD) in patients with Alzheimer's disease (AD), it is unclear which part of the WMC may play the most important role in BPSD. This study was designed to investigate the relationship between the location of WMC and the severity of BPSD in AD patients. Methods: Among patients diagnosed with Alzheimer's disease between 2009 and 2014, 387 patients were retrospectively reviewed after those with pre-existing organic brain syndrome, psychiatric diseases, or toxic-metabolic encephalopathy were excluded. Patients' demographic and laboratory data, WMC measured with brain computed tomography and scored using the age-related white matter changes (ARWMC) scale, and neuropsychological tests, including the cognitive abilities screening instrument (CASI), the Mini-Mental State Examination (MMSE), the clinical dementia rating scale with sum-box (CDR-SB), and the neuropsychiatric inventory (NPI) were analyzed. Results: There was no significant difference in the NPI between patients with and without a history of stroke, hypertension, and diabetes. No significant difference in the NPI was identified between different sexes or different Apolipoprotein E (APOE) alleles. The NPI score was significantly correlated with the duration of education (r = -0.4515, P = 0.0172), CASI (r = -0.2915, P < 0.0001), MMSE (r = -0.8476, P < 0.0001), and CDR-SB (r = 2.2839, P < 0.0001). WMC in the right frontal lobe showed a significant difference in NPI in comparison to those without WMC (P = 0.0255). After adjusting for age, duration of education, and CASI, WMC in the right frontal lobe remained significantly associated with the NPI score (β = 3.8934, P = 0.042). Conclusions: WMC involving the right frontal lobe may play an important role in the BPSD in AD patients during their dementia diagnosis. Further studies are necessary to confirm whether controlling the risk factors of WMC can slow the progression of BPSD.Citation Lin TC, Lin YH, Kao LL, Kao YH, Yang YH, Chou PS, Wu MN. An association between the location of white matter changes and the behavioral and psychological symptoms of dementia in Alzheimer's disease patients.

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Behavioral changes in early ALS correlate with voxel-based morphometry and diffusion tensor imaging

Cited by 81 publications

References 34 publications

Neuroimaging Correlates of Frontotemporal Dementia Associated with SQSTM1 Mutations

Neuroimaging Correlates of Frontotemporal Dementia Associated with SQSTM1 Mutations

Amyotrophic Lateral Sclerosis: An Introduction to Treatment and Trials

An association between the location of white matter changes and the behavioral and psychological symptoms of dementia in Alzheimer's disease patients

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