Behavioral Arousal and Neural Activation as Radiosensitive Reactions

Hunt, Edward Livingston; Kimeldorf, Donald J.

doi:10.2307/3571517

Cited by 15 publications

(4 citation statements)

References 35 publications

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“…Furthermore, Hunt and Kimeldorf (1964) in another study analyzing behavioral arousal and neural activation as radiosensitive reactions argue that the heart rate and arousal reactions to X-ray exposure in Sprague-Dawley rats tends to reject the idea of stimulation via abscopal effects at sites that are away from nervous tissue but agrees with the concept that ionizing radiation can stimulate the nervous system. In this study, they argued that the sensory deprivation could be caused by cortical inhibition and that chemoreceptors are most likely stimulated by ionizing radiation, since they have radiosensitive biochemical systems at the transduction or early amplification stages of receptor function.…”

Section: Signaling Disruptionmentioning

confidence: 98%

“…They found that the best dose rate threshold to see a response to the flickering train of beta radiation was around the range of 0.02-0.06 R/s and that the maximum amplitude response occurred within 5 min. Hunt and Kimeldorf (1964) when experimenting with Sprague-Dawley rats with a Maxitron X-ray unit found signs of behavioral arousal and neural activation. The experiment consisted of a 2-h test period with 5-min intervals for the first 30 and 10-min intervals for the remainder of the 2-h period.…”

Section: Radiotaxis Avoidance and Behavioral Arousalmentioning

confidence: 99%

“…Hunt and Kimeldorf ( 1964 ) when experimenting with Sprague-Dawley rats with a Maxitron X-ray unit found signs of behavioral arousal and neural activation. The experiment consisted of a 2-h test period with 5-min intervals for the first 30 and 10-min intervals for the remainder of the 2-h period.…”

Section: Radiotaxis Avoidance and Behavioral Arousalmentioning

confidence: 99%

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X-ray perception: Animal studies of sensory and behavioral responses to X-rays

Mantraratnam

Bonnet

Rowe

et al. 2022

Front. Cell. Neurosci.

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Since their discovery in 1895, many studies have been conducted to understand the effect of X-rays on neural function and behavior in animals. These studies examined a range of acute and chronic effects, and a subset of studies has attempted to determine if X-rays can produce any sensory responses. Here we review literature on animal behavioral responses to X-rays from 1895 until 2021 to assess the evidence for detection of X-rays by sensory receptors in animals. We focus on the changes in appetitive and consummatory behavior, radiotaxis, behavioral arousal, and olfactory responses to X-rays that have been reported in the literature. Taken together, the reviewed literature provides a large body of evidence that X-rays can induce sensory responses in a wide variety of animals and also suggests that these responses are mediated by known sensory receptors. Furthermore, we postulate the role of reactive oxygen species (ROS), the most biologically active byproduct of X-rays, as a key mediator of sensory receptor responses to X-rays.

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Section: Signaling Disruptionmentioning

confidence: 98%

Section: Radiotaxis Avoidance and Behavioral Arousalmentioning

confidence: 99%

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X-ray perception: Animal studies of sensory and behavioral responses to X-rays

Mantraratnam

Bonnet

Rowe

et al. 2022

Front. Cell. Neurosci.

View full text Add to dashboard Cite

show abstract

“…Later it was found that the brain functions and behaviour may be altered with very small doses of radiation, and the previous conception was submitted to criticism (LEBE-DINSKY et coll. 1958, GANGLOFF & HALEY 1960, HUNT & KIMELDORF 1964. Blood vessels and glial cells were found to be more susceptible to the radiation injury than neurons, and white matter more than gray (RUBIN & CASARETT 1968).…”

mentioning

confidence: 99%