Behavioral and physiological effects of photoperiod-induced migratory state and leptin on a migratory bird, Zonotrichia albicollis: I. Anorectic effects of leptin administration

Cerasale, David J.; Zajac, Daria M.; Guglielmo, Christopher G.

doi:10.1016/j.ygcen.2011.08.025

Cited by 28 publications

(25 citation statements)

References 97 publications

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“…Leptin injections did not cause a reduction of foraging rate or fat mass in birds that were in migration mode (Cerasale et al, 2011). However, the molecular mechanisms involved in the modulation of the response to leptin in avian migrants have not been elucidated.…”

Section: Discussionmentioning

confidence: 94%

“…Recent study on the white-throated sparrow Zonotrichia albicollis demonstrated that leptin affects body composition and foraging rate, but only in birds during their wintering state (Cerasale et al, 2011). Leptin injections did not cause a reduction of foraging rate or fat mass in birds that were in migration mode (Cerasale et al, 2011).…”

Section: Discussionmentioning

confidence: 96%

“…It has even been proposed that in birds the gene encoding leptin has been lost during the course of evolution (Pitel and Faraut, 2010). On the other hand, there are several reports demonstrating the presence of leptin (Taouis et al, 1998;Ashwell et al, 1999a;Kochan et al, 2006a;Quillfeldt et al, 2009) and its receptor (Richards and Poch, 2003;Liu et al, 2007;Ohkubo et al, 2007;Cerasale et al, 2011) in wild and domestic birds. Assays based on antibody-antigen interactions enable detection of leptin or at least leptin-like protein, which is very similar in size and structure (Dridi et al, 2000a;Kochan et al, 2006a;Neglia et al, 2007;Quillfeldt et al, 2009;Kordonowy et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

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Circulating leptin levels do not reflect the amount of body fat in the dunlin Calidris alpina during migration

Gogga

Karbowska

Kochan

et al. 2013

General and Comparative Endocrinology

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Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Circulating leptin levels do not reflect the amount of body fat in the dunlin Calidris alpina during migration

Gogga

Karbowska

Kochan

et al. 2013

General and Comparative Endocrinology

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“…In white-throated sparrows, peripheral injections of murine leptin inhibited feeding and reduced body mass in the winter condition, but not in the migratory condition , suggesting that a change in leptin sensitivity could be permissive to excess feeding and fattening in migrants. Although leptin receptors were known to be present in the hypothalamus and other brain and peripheral regions of birds (Boswell and Dunn, 2015;Cerasale et al, 2011), the existence of avian leptin was not definitively shown until recently, and it is not expressed by adipose tissue (Friedman-Einat et al, 2014;Huang et al, 2014). Avian leptin may have autocrine or paracrine functions within the brain and its signaling functions are not understood (Boswell and Dunn, 2015).…”

Section: How Do Birds and Bats Get Fat?mentioning

confidence: 99%

Obese super athletes: fat-fueled migration in birds and bats

Guglielmo

2018

Journal of Experimental Biology

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123

112

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Migratory birds are physiologically specialized to accumulate massive fat stores (up to 50-60% of body mass), and to transport and oxidize fatty acids at very high rates to sustain flight for many hours or days. Target gene, protein and enzyme analyses and recent -omic studies of bird flight muscles confirm that high capacities for fatty acid uptake, cytosolic transport, and oxidation are consistent features that make fat-fueled migration possible. Augmented circulatory transport by lipoproteins is suggested by field data but has not been experimentally verified. Migratory bats have high aerobic capacity and fatty acid oxidation potential; however, endurance flight fueled by adipose-stored fat has not been demonstrated. Patterns of fattening and expression of muscle fatty acid transporters are inconsistent, and bats may partially fuel migratory flight with ingested nutrients. Changes in energy intake, digestive capacity, liver lipid metabolism and body temperature regulation may contribute to migratory fattening. Although control of appetite is similar in birds and mammals, neuroendocrine mechanisms regulating seasonal changes in fuel store set-points in migrants remain poorly understood. Triacylglycerol of birds and bats contains mostly 16 and 18 carbon fatty acids with variable amounts of 18:2n-6 and 18:3n-3 depending on diet. Unsaturation of fat converges near 70% during migration, and unsaturated fatty acids are preferentially mobilized and oxidized, making them good fuel. Twenty and 22 carbon n-3 and n-6 polyunsaturated fatty acids (PUFA) may affect membrane function and peroxisome proliferator-activated receptor signaling. However, evidence for dietary PUFA as doping agents in migratory birds is equivocal and requires further study.

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“…(7), podając leptynę amerykańskiemu trznadlowi -pasówce białogardłej Zonotrichia albicollis na różnych etapach cyklu życiowego -wykazali, że hormon ten wpływa na masę tkanki tłuszczowej i na masę ciała oraz na tempo żerowania, jednak tylko u osobników zimujących. Podawanie leptyny nie zmniejszyło pobierania pokarmu, nie obniżyło też masy ciała ani ilości zgromadzonych lipidów u osobników będących w fazie migracji (7). Wyniki te sugerują występowanie przejściowej leptynooporności również u ptaków.…”

Section: Leptynooporność U Zwierzątunclassified

Physiological leptin resistance

Gogga¹,

Karbowska²,

Meissner³

et al. 2016

Medycyna Weterynaryjna

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Leptin is an adipose tissue-derived hormone whose circulating levels correlate with the amount of body fat stores. The main function of this adipokine is to regulate energy metabolism. By modulating the expression of orexigenic and anorexigenic neuropeptides in the hypothalamus, leptin reduces appetite. It also increases energy expenditure, contributing to the decrease of body fat and body weight. Mutations in the leptin receptor gene or prolonged consumption of a high-fat diet may impair leptin action, leading to leptin resistance. Resistance to leptin can also be an adaptive response that occurs in seasonal animals and in pregnant mammals. Reversible insensitivity to the satiety signal of leptin promotes hyperphagia, which is essential for animals living in dynamic environments and experiencing seasonal variation in food availability, since it allows them to forage intensely when food is abundant and accumulate fat reserves necessary to survive periods when food is scarce. Moreover, leptin resistance and subsequent hyperphagia develop during pregnancy in order to meet the energy needs of the growing fetus. Physiological leptin resistance may be due to impaired transport of leptin across the blood-brain barrier and/or to decreased sensitivity of the hypothalamus to this hormone resulting from an inhibition of leptin signalling in hypothalamic neurons. In pregnancy, an increased resistance to leptin action is also mediated by the binding of this adipokine to its placenta-derived soluble receptor. Reduced entry of leptin into the brain as well as alterations in the leptin signalling pathway in the hypothalamus leads to a transient decrease in sensitivity to this hormone preventing appetite suppression.

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Behavioral and physiological effects of photoperiod-induced migratory state and leptin on a migratory bird, Zonotrichia albicollis: I. Anorectic effects of leptin administration

Cited by 28 publications

References 97 publications

Circulating leptin levels do not reflect the amount of body fat in the dunlin Calidris alpina during migration

Circulating leptin levels do not reflect the amount of body fat in the dunlin Calidris alpina during migration

Obese super athletes: fat-fueled migration in birds and bats

Physiological leptin resistance

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