Behavioral and Neurophysiological Implications of Pathological Human Tau Expression in Serotonin Neurons
Nazmus S. Khan,
Juan Uribe Isaza,
Nahid Rouhi
et al.
Abstract:Alzheimer's disease (AD) is a progressive degenerative disorder that results in a severe loss of brain cells and irreversible cognitive decline. Memory problems are the most recognized symptoms of AD. However, approximately 90% of patients diagnosed with AD suffer from behavioral symptoms, including mood changes and social impairment years before cognitive dysfunction. Recent evidence indicates that the dorsal raphe nucleus (DRN) is among the initial regions that show tau pathology, which is a hallmark feature… Show more
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