Behavioral and neuropathological manifestations of nutritionally induced central nervous system “aging” in the rat

Lal, Harbans; Pogacar, S.; Daly, Patrick; Puri, Surendra K.

doi:10.1016/s0079-6123(08)60683-4

Cited by 38 publications

(14 citation statements)

References 20 publications

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“…In the early 1970s, it was reported that there was no significant effect of vitamin E deficiency on the learning ability of rats, although they needed more trials to acquire a conditioned response (238). The most striking effect of vitamin E deficiency in these experiments was the impaired retention of a one-trial experience, a task dependent on reference memory (238). In similar experiments, the effect of vitamin E deficiency on reference and working memory were subtle at best (367).…”

Section: Tocopherol (Vitamin E)mentioning

confidence: 94%

“…Very few studies have addressed the role of vitamin E in normal memory function. In the early 1970s, it was reported that there was no significant effect of vitamin E deficiency on the learning ability of rats, although they needed more trials to acquire a conditioned response (238). The most striking effect of vitamin E deficiency in these experiments was the impaired retention of a one-trial experience, a task dependent on reference memory (238).…”

Section: Tocopherol (Vitamin E)mentioning

confidence: 98%

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Reactive Oxygen Species in the Regulation of Synaptic Plasticity and Memory

Massaad

Klann

2011

Antioxidants & Redox Signaling

474

350

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The brain is a metabolically active organ exhibiting high oxygen consumption and robust production of reactive oxygen species (ROS). The large amounts of ROS are kept in check by an elaborate network of antioxidants, which sometimes fail and lead to neuronal oxidative stress. Thus, ROS are typically categorized as neurotoxic molecules and typically exert their detrimental effects via oxidation of essential macromolecules such as enzymes and cytoskeletal proteins. Most importantly, excessive ROS are associated with decreased performance in cognitive function. However, at physiological concentrations, ROS are involved in functional changes necessary for synaptic plasticity and hence, for normal cognitive function. The fine line of role reversal of ROS from good molecules to bad molecules is far from being fully understood. This review focuses on identifying the multiple sources of ROS in the mammalian nervous system and on presenting evidence for the critical and essential role of ROS in synaptic plasticity and memory. The review also shows that the inability to restrain either age-or pathology-related increases in ROS levels leads to opposite, detrimental effects that are involved in impairments in synaptic plasticity and memory function.

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Section: Tocopherol (Vitamin E)mentioning

confidence: 94%

Section: Tocopherol (Vitamin E)mentioning

confidence: 98%

Reactive Oxygen Species in the Regulation of Synaptic Plasticity and Memory

Massaad

Klann

2011

Antioxidants & Redox Signaling

474

350

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“…The relation is supported by animal studies, in which rodents fed diets high in vitamin E demonstrated improved cognitive functioning during aging, with fewer errors in maze tests, 6 a greater rate of learning, 7 and greater memory retention. 7,56 A causal interpretation of the observed findings would require additional evidence by other longitudinal epidemiologic studies and/or primary prevention trials. CME Announcement CME Hiatus: July Through December 2002.…”

Section: Statistical Analysesmentioning

confidence: 99%

Vitamin E and Cognitive Decline in Older Persons

Morris¹,

Evans²,

Bienias³

et al. 2002

Arch Neurol

310

176

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“…Relatively large amounts of lipofuscin may be associated with adverse effects in the central nervous systems, including loss of neurons (72,76); large deposits ofmelanin (produced by free radical reactions) also appear to be associated with detrimental changes (77). Vitamin E-deficient diets increase CNS lipofuscin and depress function (78). Further, free radical reactions may be significantly involved in formation of the neuritic plaques (senile plaques) associated with senile dementia of the Alzheimer type (79,80).…”

Section: )mentioning

confidence: 99%

The aging process.

Harman¹

1981

Proc. Natl. Acad. Sci. U.S.A.

1,577

672

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Aging is the progressive accumulation of changes with time that are associated with or responsible for the ever-increasing susceptibility to disease and death which accompanies advancing age. These time-related changes are attributed to the aging process. The nature ofthe aging process has been the subject ofconsiderable speculation. Accumulating evidence now indicates that the sum ofthe deleterious free radical reactions going on continuously throughout the cells and tissues constitutes the aging process or is a major contributor to it. In mammalian systems the free radical reactions are largely those involving oxygen.Dietary manipulations expected to lower the rate of production of free radical reaction damage have been shown (i) to increase the life span of mice, rats, fruit flies, nematodes, and rotifers, as well as the "life span" of neurospora; (#-) to inhibit development ofsome forms ofcancer; (ii) to enhance humoral and cell-mediated immune responses; and (iv) to slow development of amyloidosis and the autoimmune disorders of NZB and NZB/NZW mice. In addition, studies strongly suggest that free radical reactions play a significant role in the deterioration of the cardiovascular and central nervous systems with age.The free radical theory of aging provides reasonable explanations for age-associated phenomena, including (i) the relationship of the average life spans of mammalian species to their basal metabolic rates, (ii) the clustering of degenerative diseases in the terminal part of the life span, (iii) the beneficial effect of food restriction on life span, (iv) the greater longevity of females, and (v) the increase in autoimmune manifestations with age.

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Behavioral and neuropathological manifestations of nutritionally induced central nervous system “aging” in the rat

Cited by 38 publications

References 20 publications

Reactive Oxygen Species in the Regulation of Synaptic Plasticity and Memory

Reactive Oxygen Species in the Regulation of Synaptic Plasticity and Memory

Vitamin E and Cognitive Decline in Older Persons

The aging process.

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