Behavioral and neurodevelopmental precursors to binge-type eating disorders: support for the role of negative valence systems

Abstract

Background Pediatric loss-of-control eating is a robust behavioral precursor to binge-type eating disorders. Elucidating precursors to loss-of-control eating and binge-type eating disorders may refine developmental risk models of eating disorders and inform interventions. Method We review evidence within constructs of the Negative Valence Systems (NVS)-domain, as specified by the Research Domain Criteria framework. Based on published studies, we propose an integrated NVS model of binge-type eating disorder risk. Results Data implicate altered corticolimbic functioning, neuroendocrine dysregulation, and self-reported negative affect as possible risk-factors. However, neuroimaging and physiological data in children and adolescents are sparse, and most prospective studies are limited to self-report measures. Conclusions We discuss a broad NVS framework for conceptualizing early risk for binge-type eating disorders. Future neural and behavioral research on the developmental trajectory of loss-of-control and binge-type eating disorders is required.

Psychometric properties of the brief loss of control over eating scale (LOCES‐B) in early adolescents

“…Specifically, adolescents with higher LOCES‐B total scores reported greater body image dissatisfaction, higher internalizing symptoms, and lower trait effortful control. These findings are consistent with prior research on the psychological correlates of LOC eating in adolescents (Goldschmidt, ; Reinblatt et al, ; Tanofsky‐Kraff et al, ; Vannucci et al, ). LOC eating frequency and the LOCES‐B appear to capture distinct, and potentially clinically meaningful, aspects of LOC eating, as both measures remained significant predictors when accounting for shared variance.…”

Estrogenic suppression of binge‐like eating elicited by cyclic food restriction and frustrative‐nonreward stress in female rats

“…Here, we report novel studies of the neuroendocrine influence on binge‐like eating in a rat model in which binge‐like eating was elicited by a history of cyclic food restriction and an acute frustrative‐nonreward procedure, in which rats were exposed to a familiar palatable food, without being allowed access to it, immediately before the binge test (Cifani et al, ; Micioni Di Bonaventura et al, ; Micioni Di Bonaventura, Vitale, Massi, & Cifani, ; Micioni Di Bonaventura, Cifani, Lambertucci, Volpini, Cristalli & Massi, ; Micioni Di Bonaventura, Ubaldi, Liberati, Ciccocioppo, Massi & Cifani, ; Pucci, Micioni Di Bonaventura, Giusepponi, Romano, Filaferro, Maccarrone, … D'Addario, in press). This procedure has face validity as a model of the putative contributions of dieting and negative‐valence states, especially psychosocial stress, to emotional and binge eating in humans (American Psychiatric Association, ; Masheb & Grilo, ; Mathes et al, ; Sanislow et al, ; Treasure et al, ; Vannucci et al, ; van Strien, ).…”

“…Because the majority of women with eating disorders have a history of dieting and because negative affect often precipitates binge eating (Mathes et al, ; Treasure et al, ), Cifani, Polidori, Melotto, Ciccocioppo, & Massi () and Cifani, Micioni Di Bonaventura, Ciccocioppo, & Massi (2013) developed a rat model involving a history of cyclic food restriction and an acute psychological stressor, that is, a frustrative‐nonreward procedure consisting of 15 min exposure to the odor and sight of a familiar palatable food, just before offering the food. Frustrative nonreward and similar aversive experiences are thought to activate the negative‐valence system, which includes the neuroendocrine stress system and cortico‐limbic neural circuits that produce anxiety, fear, frustration, depression, and other negative‐emotional states, which in turn contribute to binge eating and other psychopathologies as well as their animal homologues (Sanislow, Pine, Quinn, Kozak, Garvey, Heinssen, … Cuthbert, 2010; Vannucci, Nelson, Bongiorno, Pine, Yanovski, & Tanofsky‐Kraff, ). Importantly, although the frustrative nonreward used in our model increased plasma corticosterone levels, this occurred regardless of food‐restriction history, so was not sufficient to account for binge‐like eating (Cifani et al, ; Cifani, Micioni Di Bonaventura, Vitale, Ruggieri, Ciccocioppo & Massi, ).…”

Long-term safety and efficacy of guanfacine extended release in children and adolescents with ADHD

“…In particular, concerns have been raised about potential long-term effects of Electronic supplementary material The online version of this article (https ://doi.org/10.1007/s0078 7-018-1113-4) contains supplementary material, which is available to authorized users. stimulant and non-stimulant ADHD medications on growth and weight [10][11][12][13].…”