Behavioral and histological features of zebrafish following sedation with eugenol or propofol

Gressler, Luciane Tourem; Xavier, Maria Luiza Gallina; Bandeira, Guerino; Loebens, Luíza; Barboza, Victor dos Santos; Costa, Silvio Teixeira da; Baldisserotto, Bernardo

doi:10.1016/j.applanim.2021.105482

Cited by 4 publications

(2 citation statements)

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“…In addition, monoterpene anaesthesia has been shown to prevent the incidence of stress in different fish species by reducing cellular stress markers levels (Corso et al, 2019; Cunha et al, 2010; Palić et al, 2006; Taheri Mirghaed, Ghelichpour, et al, 2018), although discrepant results have been reported between the different monoterpenes (Pereira‐da‐Silva et al, 2014; Yousefi et al, 2019, 2022; Yousefi, Hoseini, et al, 2018). Moreover, there are no noticeable behavioural changes after anaesthesia (Teta & Kaiser, 2019) unless exposure is prolonged over time (Gressler et al, 2021). Still, only a few studies have examined the post‐behavioural effects of monoterpene anaesthesia.…”

Section: Discussionmentioning

confidence: 99%

“…have been reported between the different monoterpenes (Pereirada-Silva et al, 2014;Yousefi et al, 2019Yousefi et al, , 2022. Moreover, there are no noticeable behavioural changes after anaesthesia (Teta & Kaiser, 2019) unless exposure is prolonged over time (Gressler et al, 2021). Still, only a few studies have examined the post-behavioural effects of monoterpene anaesthesia.…”

Section: Discussionmentioning

confidence: 99%

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A meta‐analytic review of monoterpene for fish anaesthesia

et al. 2023

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The use of anaesthetic agents has been increasing to address the welfare needs of different fish species in scientific and aquaculture practices. MS‐222 is the most used synthetic anaesthetic but some limitations and side effects have been reported. Natural substances have been used as potential substitutes with clove oil playing an important role due to its eugenol content. Yet, other monoterpenes have shown anaesthetic properties in different fish species. As such, a quantitative assessment has been conducted to explicitly relate and summarise the use of monoterpenes with described anaesthetic properties in fish. A combined PubMed, Web of Science, Scopus, PubMed Central and Europe PMC electronic database search was performed, from January 2002 to August 2022, following the PRISMA guidelines. Out of 1555 articles retrieved from the literature search, 30 English reports met the criteria for inclusion in the meta‐analysis through a generic inverse‐variance method (random‐effects model) and according to the fish age. The findings show a total of 10 different monoterpenes with high homogeneity and effectiveness in inducing anaesthesia and recovery according to the fish anaesthetic criteria. Further subgroup analysis showed these effects were independent of fish age. Meta‐regression of the included studies revealed an inverse linear association between anaesthesia induction and recovery time and water bath temperature while no further correlation was found with other confounding factors (body weight, water pH and dissolved oxygen levels). Although further studies will be required, this meta‐analysis provides robust evidence that different monoterpenes serve as an attractive and effective alternative for fish anaesthesia although water bath temperature also played an important role in anaesthesia outcome.

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