Behavioral and genoprotective effects of Vaccinium berries intake in mice

Barros, Daniela M.; Amaral, Olavo B.; Izquierdo, Iván; Geracitano, Laura A.; Raseira, M. do C. B.; Henriques, Amélia Teresinha; Ramirez, Maria Rosana

doi:10.1016/j.pbb.2006.05.001

Cited by 125 publications

(89 citation statements)

References 41 publications

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“…There is also extensive evidence that berries, in particular blueberries, are effective at reversing age-related deficits in motor function and spatial working memory [5,12,45,46,129]. In addition to spatial memory, blueberry supplementation has been shown to improve 'object recognition memory' [34] and 'inhibitory fear conditioning learning' [5].…”

Section: Flavonoid-induced Improvements In Memory Learning and Cognimentioning

confidence: 99%

“…In addition to spatial memory, blueberry supplementation has been shown to improve 'object recognition memory' [34] and 'inhibitory fear conditioning learning' [5]. Blueberry appears to have a pronounced effect on short-term memory [82] and has also been shown to improve long-term reference memory following 8 weeks of supplementation.…”

Section: Flavonoid-induced Improvements In Memory Learning and Cognimentioning

confidence: 99%

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The neuroprotective potential of flavonoids: a multiplicity of effects

et al. 2008

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Flavonoids exert a multiplicity of neuroprotective actions within the brain, including a potential to protect neurons against injury induced by neurotoxins, an ability to suppress neuroinflammation, and the potential to promote memory, learning and cognitive function. These effects appear to be underpinned by two common processes. Firstly, they interact with critical protein and lipid kinase signalling cascades in the brain leading to an inhibition of apoptosis triggered by neurotoxic species and to a promotion of neuronal survival and synaptic plasticity. Secondly, they induce beneficial effects on the vascular system leading to changes in cerebrovascular blood flow capable of causing angiogenesis, neurogenesis and changes in neuronal morphology. Through these mechanisms, the consumption of flavonoid-rich foods throughout life holds the potential to limit neurodegeneration and to prevent or reverse age-dependent loses in cognitive performance. The intense interest in the development of drugs capable of enhancing brain function means that flavonoids may represent important precursor molecules in the quest to develop of a new generation of brain enhancing drugs.

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Section: Flavonoid-induced Improvements In Memory Learning and Cognimentioning

confidence: 99%

Section: Flavonoid-induced Improvements In Memory Learning and Cognimentioning

confidence: 99%

The neuroprotective potential of flavonoids: a multiplicity of effects

et al. 2008

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“…Anthocyanins from bilberry alleviated pruritus in a mouse model of chronic allergic contract dermatitiss [158] Rats Flavonoids from fruit residues of V. vitis-idaea could lower serum uric acid and protect kidney in adenine-reduced hyperuricemia [132] Mice Anthocyanins from bilberry showed protective effect on gastric ulcer [159] Mice The bilberry fruit extract, in a dose dependent manner, induced the resolution of liver fibrosis by decreasing oxidative stress and inactivating HSCs via down-regulation of fibrogenic cytokines, TGF-1 and TNF- [160] Rats and Mice Anthocyanins from bilberry provided moderate protection against Dox-induced cardiac and hematopoietic damage [161] Mice Blueberry extract showed antinociceptive activity [162] Mice Bilberry extract showed protective effective against endotoxin-induce uveitis [163] Mice Anthocyanins from lowbush blueberry showed hypoglycemic activity [164] Mice Bilberry extract played an important role in protecting against restraint stress-induced liver damage by both scavenging free radicals activity and lipid peroxidase inhibitory effect [165] Mice Bilberry extract reduced the degree of oxidative stress and kidney damage induced by KBrO3 [166] Mice V. oxycoccos berries extract showed preventive effect on acetic acid-induced colitis [167] Mice V. ashei berries extract showed improvement performance in memory tasks and had protective effects on brain DNA [168] Mice extract of V. myrtillus significantly decrease the level of glucose and fructosamine in alloxan induced NOD [169] Rats Anthocyanosides from V. myrtillus appear to be effective in preventing the increase in capillary filtration of albumin (CFA) and the failure of lymphatic uptake of interstitial albumin [170] Mice Extract from V. ashei produced antinociceptive effects [162] Mice Extract from V. corymbosum did not induce in vivo DNA damage in peripheral blood cells of 12-day old female or male Swiss mice but the micronucleus assay indicated that the extract presented clastogenic or aneugenic effects or dihydroflavonol stage, and methylation, glycosylation, and dimethylallylation are also possible, increasing the range of compounds enormously.…”

Section: Micementioning

confidence: 99%

Anthocyanins and Flavonoids of Vaccinium L.

Su¹

2012

TOPHARMCJ

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Vaccinium L., comprising approximately 450 species primarily in the Northern Hemisphere, is a genus of shrubs or lianas in the family Ericaceae. The berries of many species are harvested for household consumption and commercial sale. The genus produces a wide range of compounds such as anthocyanins, flavonoids, chromones, coumarins, lignans, benzoic acids, iridoids, sterols, and triterpenoids, but is best known for the production of anthocyanins and flavonoids. Extracts and isolates of anthocyanins and flavonoids from Vaccinium fruits or leaves showed antioxidative, anti-inflammatory, antitumor, antiviral, vasoprotective, and antifungal activities. To data, more than 116 anthocyanins and flavonoids compounds have been isolated and identified primarily from the fruits or leaves of Vaccinium. This article reviews phytochemistry and pharmaceutical properties of these compounds.

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“…There is also extensive evidence that berries, in particular blueberries (BB), are effective at reversing age-related deficits in motor function and spatial working memory [9,19,34,67,81,101,102,115,162,188,189]. The benefits of anthocyanin-rich blueberries have been shown against both behavioural and neuronal decline associated with ageing [102,189,224].…”

Section: An Overviewmentioning

confidence: 99%

The impact of flavonoids on spatial memory in rodents: from behaviour to underlying hippocampal mechanisms

et al. 2009

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Emerging evidence suggests that a group of dietary-derived phytochemicals known as flavonoids are able to induce improvements in memory, learning and cognition. Flavonoids have been shown to modulate critical neuronal signalling pathways involved in processes of memory, and therefore are likely to affect synaptic plasticity and long-term potentiation mechanisms, widely considered to provide a basis for memory. Animal dietary supplementation studies have further shown that flavonoidrich foods are able to reverse age-related spatial memory and spatial learning impairments. A more accurate understanding of how a particular spatial memory task works and of which aspects of memory and learning can be assessed in each case, are necessary for a correct interpretation of data relating to diet-cognition experiments. Further understanding of how specific behavioural tasks relate to the functioning of hippocampal circuitry during learning processes might be also elucidative of the specific observed memory improvements. The overall goal of this review is to give an overview of how the hippocampal circuitry operates as a memory system during behavioural tasks, which we believe will provide a new insight into the underlying mechanisms of the action of flavonoids on cognition.

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Behavioral and genoprotective effects of Vaccinium berries intake in mice

Cited by 125 publications

References 41 publications

The neuroprotective potential of flavonoids: a multiplicity of effects

The neuroprotective potential of flavonoids: a multiplicity of effects

Anthocyanins and Flavonoids of Vaccinium L.

The impact of flavonoids on spatial memory in rodents: from behaviour to underlying hippocampal mechanisms

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