Behavioral and evoked-potential thresholds in young and old Mongolian gerbils (Meriones unguiculatus)

Hamann, Ingo; Gleich, Otto; Klump, Georg M.; Kittel, Malte C.; Boettcher, Flint A.; Schmiedt, Richard A.; Strutz, Jürgen

doi:10.1016/s0378-5955(02)00454-9

Cited by 27 publications

(47 citation statements)

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“…The setup and methods for psychoacoustic measurements in gerbils have been described in detail before (Hamann et al 2002) and are summarized only briefly. Testing was performed in sound-shielded setups (IAC Mini 250) presenting acoustic stimuli via a stereo amplifier (Kenwood KA 1030 or KA 3300) and a calibrated free-field speaker (Canton Plus XS).…”

Section: Methodsmentioning

confidence: 99%

“…Pulses of broad-band noise (no ramps and rise/fall time limited in bandwidth by the frequency response of the speaker from 65 to 30,000 Hz; for details see Hamann et al 2002) were generated by randomly selecting 800-ms samples from a sound file of 10 of white noise generated by Cool Edit (Syntrillium [Software Corporation, Phoenix, AZ, USA]; 50-kHz sampling rate). Silent gaps of the desired duration (determined between zero amplitude points) were introduced in the center of the 800-ms noise pulse, keeping the total duration of the stimulus constant.…”

Section: Stimulimentioning

confidence: 99%

“…Acoustic calibration was performed using a Brü el & Kjaer 0.5-in. 4134 microphone connected to a 2804 microphone power supply and a Hewlett Packard 35665A Dynamic Signal Analyzer (for details see Hamann et al 2002). Noise pulses containing gaps of variable duration were used to construct psychometric functions using the method of constant stimuli.…”

Section: Stimulimentioning

confidence: 99%

“…In a first step, all gerbils were trained to respond to a pulse of broadband noise in quiet and the threshold for the detection of the noise pulse was determined (Hamann et al 2002). After threshold measurements in quiet, the animals had to learn to discriminate a stimulus with a gap from a background stimulus without a gap.…”

Section: Training and Performance Of The Gerbilsmentioning

confidence: 99%

“…In contrast to chinchilla and guinea pig, gerbils have a shorter life span of 3-4 years (Cheal 1986), which makes them more practical for studying the effects of aging. Another advantage is that many studies have already investigated various aspects of age-dependent changes in the auditory system of the gerbil (e.g., Henry et al 1980;Czibulka and Schwartz 1991;Tarnowski et al 1991;Schulte and Schmiedt 1992;Boettcher et al 1993Boettcher et al , 1996Gratton et al 1995Gratton et al , 1996Hellstrom and Schmiedt 1996;Schmiedt et al 1996;Sinnott et al 1997;Gleich and Strutz 2002;Hamann et al 2002). Among these, the study by Boettcher et al (1996) using auditory brainstem recordings already provides physiological data on the effect of age on temporal resolution in the gerbil.…”

Section: Introductionmentioning

confidence: 99%

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Age-Dependent Changes of Gap Detection in the Mongolian Gerbil ( Meriones unguiculatus )

Hamann

Gleich

Klump

et al. 2004

JARO - Journal of the Association for Research in Otolaryngolog

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Gap detection using broadband noise was characterized in a group of young gerbils from the breeding colony of the University of Regensburg (RB gerbils), old RB gerbils, and old gerbils from the breeding colony of the University of South Carolina (SC gerbils). Data from old RB and old SC gerbils were not significantly different and were subsequently combined for a comparison with data from the group of young RB gerbils. Level dependence of gap-detection thresholds in young and old domesticated gerbils resembled the typical mammalian pattern of level dependence. Gap-detection thresholds of old gerbils were significantly elevated at 30 dB SL and 50 dB SPL as compared with young gerbils. Compared with young gerbils tested at 30 dB SL and 50 dB SPL, the distribution of gap-detection thresholds in old gerbils was broader with a spread to higher gap-detection thresholds. Some old animals retained excellent temporal resolution, while some showed impaired gap detection. The gap-detection data collected in young and old gerbils resemble previously published data from humans of different age and confirm that gerbils are a useful model to study age-dependent changes in temporal processing.

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Section: Methodsmentioning

confidence: 99%

Section: Stimulimentioning

confidence: 99%

Section: Stimulimentioning

confidence: 99%

Section: Training and Performance Of The Gerbilsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Age-Dependent Changes of Gap Detection in the Mongolian Gerbil ( Meriones unguiculatus )

Hamann

Gleich

Klump

et al. 2004

JARO - Journal of the Association for Research in Otolaryngolog

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Hearing in Rodents

Dent

Screven

Kobrina

2018

Rodent Bioacoustics

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Activation in the auditory pathway of the gerbil studied with 18F-FDG PET: effects of anesthesia

et al. 2018

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Here, we present results from an F-fluorodeoxyglucose (F-FDG) positron emission tomography (PET) study in the Mongolian gerbil, a preferred animal model in auditory research. One major issue in preclinical nuclear imaging, as well as in most of the neurophysiological methods investigating auditory processing, is the need of anesthesia. We compared the usability of two types of anesthesia which are frequently employed in electrophysiology, ketamine/xylazine (KX), and fentanyl/midazolam/medetomidine (FMM), for valid measurements of auditory activation with F-FDG PET. Gerbils were placed in a sound-shielding box and injected withF-FDG. Two acoustic free-field conditions were used: (1) baseline (no stimulation, 25 dB background noise) and (2) 90 dB frequency-modulated tones (FM). After 40 min of F-FDG uptake, a 30 min acquisition was performed using a small animal PET/CT system. Blood glucose levels were measured after the uptake phase before scanning. Standardized uptake value ratios for relevant regions were determined after implementing image and volume of interest templates. Scans demonstrated a significantly higher uptake in the inferior colliculus with FM stimulation compared to baseline in awake subjects (+ 12%; p = 0.02) and with FMM anesthesia (+ 13%; p = 0.0012), but not with KX anesthesia. In non-auditory brain regions, no significant difference was detected. Blood glucose levels were significantly higher under KX compared to FMM anesthesia (17.29 ± 0.42 mmol/l vs. 14.30 ± 1.91 mmol/l; p = 0.024). These results suggest that validF-FDG PET measurements of auditory activation comparable to electrophysiology can be obtained from gerbils during opioid-based anesthesia due to its limited effects on interfering blood glucose levels.

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Behavioral and evoked-potential thresholds in young and old Mongolian gerbils (Meriones unguiculatus)

Cited by 27 publications

References 50 publications

Age-Dependent Changes of Gap Detection in the Mongolian Gerbil ( Meriones unguiculatus )

Age-Dependent Changes of Gap Detection in the Mongolian Gerbil ( Meriones unguiculatus )

Hearing in Rodents

Activation in the auditory pathway of the gerbil studied with 18F-FDG PET: effects of anesthesia

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