Behavioral and Electrophysiological Indices of Negative Affect Predict Cocaine Self-Administration

Wheeler, Robert; Twining, Robert C.; Jones, Joe M.; Slater, Jennifer M.; Grigson, Patricia S.; Carelli, Regina M.

doi:10.1016/j.neuron.2008.01.024

Cited by 143 publications

(218 citation statements)

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“…Interestingly, this AMPH experience also induced a significant up-regulation of AH-V1aR expression, similarly, as observed in pair-bonded males. While it is not surprising that drugs of abuse act on the same neurobiological substrates mediating natural reward (45)(46)(47)(48), our findings provide additional evidence to support the above notion and highlights the role of the neuropeptide AVP underlying naturally induced and drugfacilitated female-directed aggression in male prairie voles. These data also indicate the utility of the prairie vole model for evaluation of the effects of drug abuse on neural systems controlling adaptive forms of social behavior, such as mate guarding.…”

Section: Discussionsupporting

confidence: 70%

Anterior hypothalamic vasopressin regulates pair-bonding and drug-induced aggression in a monogamous rodent

Gobrogge

Liu

Young

et al. 2009

Proc. Natl. Acad. Sci. U.S.A.

155

177

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After pair-bonding, male prairie voles (Microtus ochrogaster) display aggression toward novel females but not toward their female partner. Here we show that this selective aggression in pair-bonded male prairie voles is associated with increased release of vasopressin (AVP) in the anterior hypothalamus (AH). Pharmacological activation of AVP-V1a receptors (V1aR) in the AH induced selective aggression in sexually naive males, whereas V1aR blockade diminished selective aggression in pair-bonded males. Pair-bonded males also showed an increased density in V1aR binding in the AH compared to their sexually naive counterparts and overexpression of V1aR in the AH, by viral vector-mediated gene transfer, facilitated aggression toward novel females. These data demonstrate that AH-AVP is both necessary and sufficient in the regulation of selective aggression associated with pair-bonding. In the second part of this study, we examined the effects of amphetamine (AMPH) exposure on female-directed aggression and revealed the potential role of AH-AVP underlying this behavior. Repeated AMPH administration in sexually naive male prairie voles enhanced V1aR expression in the AH and induced aggression toward a familiar or unfamiliar female. In addition, this AMPH-induced aggression was blocked by intra-AH administration of a V1aR antagonist. Together, our data reveal a socioneurobiological mechanism, highlighting a critical role of AH-AVP in the regulation of aggression induced by pair-bonding or drug experience in socially monogamous male prairie voles.behavioral pharmacology ͉ drug abuse ͉ microdialysis ͉ neural plasticity ͉ viral-vector gene transfer A ggression is an agonistic behavior that plays an important role for survival and reproductive success. In both vertebrates (1) and invertebrates (2), aggression promotes fitness by acquiring territory, food, and mates, as well as by serving to protect offspring and avoid predation. In humans and nonhuman primates, aggressive behavior operates within social hierarchies to facilitate resource acquisition (3). Among the neurochemicals implicated in aggression (4, 5), arginine vasopressin (AVP), and its homolog vasotocin, have been found to regulate several forms of aggression in numerous species (6, 7) across diverse taxa (8, 9). Even in humans, central AVP correlates with aggressive behavior (10) and mediates anger (11). Therefore, the AVP system may have evolved to be primed by a wide variety of experiences to induce aggression, when appropriate, in social animals (12).Drug use can override neurobiological programs to activate maladaptive forms of agonistic behavior, engaging inappropriate types of physical aggression (13), such as domestic violence (14) and intimate partner homicide (15). As a result, chronic drug abuse can cause permanent neural reorganization (16,17), impairing the adaptive social brain (18), leading to the display of maladaptive social behavior (19). In rodent models such as hamsters, adolescent exposure to cocaine (20) or anabolic steroids (21, 22) induces ag...

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Section: Discussionsupporting

confidence: 70%

Anterior hypothalamic vasopressin regulates pair-bonding and drug-induced aggression in a monogamous rodent

Gobrogge

Liu

Young

et al. 2009

Proc. Natl. Acad. Sci. U.S.A.

155

177

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“…This association has been attributed to a major mechanism of relapse in such individuals related to a dysphoric response to drug cue exposure (Koob, 2008;Wheeler et al, 2008). Similar to the findings for smokers (Drobes et al, 2006), there was a strong observed correlation between individual variation in attentional bias effects for drug cue and negative affect stimuli for cocaine-dependent individuals.…”

Section: Discussionsupporting

confidence: 67%

“…Both the middle cingulate and lateral orbital frontal cortex nodes within this network are functionally related to the emotional processing and regulation of aversive states (Singer et al, 2004). The observed increased functional connectivity within this network with increasing attentional bias effect for cocaine cues supports the concept of negative affective responses to drug cue exposure as a precipitant of relapse to drug seeking and use behavior via negative reinforcement mechanisms (Wheeler et al, 2008;Koob, 2009). Whether this association is because of a direct negative affective response to drug cues or reflects a response to conflict between drug craving and drug unavailability in the MRI setting is not known.…”

Section: Discussionmentioning

confidence: 55%

Individual Differences in Attentional Bias Associated with Cocaine Dependence Are Related to Varying Engagement of Neural Processing Networks

Kilts

Kennedy

Elton

et al. 2013

Neuropsychopharmacol

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Cocaine and other drug dependencies are associated with significant attentional bias for drug use stimuli that represents a candidate cognitive marker of drug dependence and treatment outcomes. We explored, using fMRI, the role of discrete neural processing networks in the representation of individual differences in the drug attentional bias effect associated with cocaine dependence (AB-coc) using a word counting Stroop task with personalized cocaine use stimuli (cocStroop). The cocStroop behavioral and neural responses were further compared with those associated with a negative emotional word Stroop task (eStroop) and a neutral word counting Stroop task (cStroop). Brain-behavior correlations were explored using both network-level correlation analysis following independent component analysis (ICA) and voxel-level, brain-wide univariate correlation analysis. Variation in the attentional bias effect for cocaine use stimuli among cocaine-dependent men and women was related to the recruitment of two separate neural processing networks related to stimulus attention and salience attribution (inferior frontal-parietal-ventral insula), and the processing of the negative affective properties of cocaine stimuli (frontal-temporal-cingulate). Recruitment of a sensory-motor-dorsal insula network was negatively correlated with AB-coc and suggested a regulatory role related to the sensorimotor processing of cocaine stimuli. The attentional bias effect for cocaine stimuli and for negative affective word stimuli were significantly correlated across individuals, and both were correlated with the activity of the frontal-temporal-cingulate network. Functional connectivity for a single prefrontal-striatal-occipital network correlated with variation in general cognitive control (cStroop) that was unrelated to behavioral or neural network correlates of cocStroop-or eStroop-related attentional bias. A brain-wide mass univariate analysis demonstrated the significant correlation of individual attentional bias effect for cocaine stimuli with distributed activations in the frontal, occipitotemporal, parietal, cingulate, and premotor cortex. These findings support the involvement of multiple processes and brain networks in mediating individual differences in risk for relapse associated with drug dependence.

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“…In general, these substances are readily consumed by mice and rats and elicit appetitive orofacial reactions if infused intraorally, suggesting a positive hedonic evaluation [28,29]. Moreover, mice and rats show increased dopamine efflux and dopamine release in response to free consumption or intraoral delivery of nonnutritive sweeteners [22,30,31].…”

Section: Artificial Sweetenersmentioning

confidence: 99%

The role of dopamine in the pursuit of nutritional value

McCutcheon

2015

Physiology & Behavior

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Acquiring enough food to meet energy expenditure is fundamental for all organisms. Thus, mechanisms have evolved to allow foods with high nutritional value to be readily detected, consumed, and remembered. Although taste is often involved in these processes, there is a wealth of evidence supporting the existence of taste-independent nutrient sensing. In particular, post-ingestive mechanisms arising from the arrival of nutrients in the gut are able to drive food intake and behavioural conditioning. The physiological mechanisms underlying these effects are complex but are believed to converge on mesolimbic dopamine signalling to translate post-ingestive sensing of nutrients into reward and reinforcement value. Discerning the role of nutrition is often difficult because food stimulates sensory systems and post-ingestive pathways in concert. Thus, in this mini-review, I discuss the various methods that may be used to study post-ingestive processes in isolation including sham-feeding, nonnutritive sweeteners, post-ingestive infusions, and pharmacological and genetic methods. Using this structure, I present the evidence that dopamine is sensitive to nutritional value of certain foods and examine how this affects learning about food, the role of taste, and the implications for human obesity.

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Behavioral and Electrophysiological Indices of Negative Affect Predict Cocaine Self-Administration

Cited by 143 publications

References 84 publications

Anterior hypothalamic vasopressin regulates pair-bonding and drug-induced aggression in a monogamous rodent

Anterior hypothalamic vasopressin regulates pair-bonding and drug-induced aggression in a monogamous rodent

Individual Differences in Attentional Bias Associated with Cocaine Dependence Are Related to Varying Engagement of Neural Processing Networks

The role of dopamine in the pursuit of nutritional value

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