Behavioral and cognitive correlates of the aperiodic (1/f-like) exponent of the EEG power spectrum in adolescents with and without ADHD

Ostlund, Brendan D.; Alperin, Brittany R.; Drew, Trafton; Karalunas, Sarah L.

doi:10.1016/j.dcn.2021.100931

Cited by 95 publications

(141 citation statements)

References 60 publications

Supporting

Mentioning

125

Contrasting

Order By: Relevance

“…The relationship between a steeper 1/ƒ slope and enhanced perceptual sensitivity is in keeping with previous work examining the association between aperiodic neural dynamics and cognition (Cross et al, 2020;Ouyang et al, 2020;Ostlund et al, 2021). Here, we demonstrated that both a high 1/ƒ intercept (reflective of higher overall neural spiking) and a steeper 1/ƒ slope were predictive of enhanced perceptual sensitivity under more difficult conditions of information processing (i.e., Block 4).…”

Section: Discussionsupporting

confidence: 90%

“…There is also the potential that the present findings are limited to healthy young adults. These findings might not generalize to visuomotor performance in younger individuals undergoing both neural (for example see, Miskovic et al, 2015;Anderson & Perone, 2018;Ostlund et al, 2021) and visuomotor (Bo et al, 2006) developmental changes. Moreover, our findings might not extend to older adults given the possibility that aging-related changes in neural (Scally et al, 2018;Tian et al, 2018) andvisuomotor (Endrass et al, 2012) function might alter mechanistic relationships between aperiodic neural dynamics and perceptual-motor processes.…”

Section: Discussionmentioning

confidence: 92%

“…By contrast, a shallower slope (i.e., flattening of the aperiodic spectrum) may reflect a diminished neural excitation/inhibition balance and consequently, reduced information processing capacity. For example, children with attention deficit hyperactivity disorder (Ostlund et al, 2021) and older adults (Voytek et al, 2015;Tran et al, 2020) demonstrate shallower 1/ƒ slopes and deficits in information processing capacity relative to age-matched healthy controls. Mechanistically, shallower slopes may reflect altered GABAergic and glutamatergic activity in cortical circuitry, neurotransmitters associated with maintaining an optimal excitation/inhibition balance (Ostlund et al, 2021).…”

Section: Discussionmentioning

confidence: 99%

“…For example, children with attention deficit hyperactivity disorder (Ostlund et al, 2021) and older adults (Voytek et al, 2015;Tran et al, 2020) demonstrate shallower 1/ƒ slopes and deficits in information processing capacity relative to age-matched healthy controls. Mechanistically, shallower slopes may reflect altered GABAergic and glutamatergic activity in cortical circuitry, neurotransmitters associated with maintaining an optimal excitation/inhibition balance (Ostlund et al, 2021). From this perspective, our finding that a steeper 1/ƒ slope is associated with enhanced perceptual sensitivity (d') lends further support for the argument that a steeper resting aperiodic spectrum slope, and thus a greater inhibitory state, facilitates optimal information processing.…”

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Resting-state aperiodic neural dynamics predict individual differences in visuomotor performance and learning

Immink

Cross

Chatburn

et al. 2021

Preprint

View full text Add to dashboard Cite

An emerging body of work has demonstrated that resting-state non-oscillatory, or aperiodic, 1/f neural activity is a functional and behaviorally relevant marker of cognitive function capacity. In the motor domain, previous work has only applied 1/f analyses to description of action coordination and performance. The value of aperiodic resting-state neural dynamics as a marker of individual visuomotor performance capacity remains unknown. Accordingly, the aim of this work was to investigate if individual 1/f intercept and slope parameters of aperiodic resting-state neural activity predict reaction time and perceptual sensitivity in an immersive virtual reality marksmanship task. The marksmanship task required speeded selection of target stimuli and avoidance of non-target stimuli selection. Motor and perceptual demands were incrementally increased across task blocks and participants performed the task across three training sessions spanning one week. When motor demands were high, steeper individual 1/f slope predicted shorter reaction time. This relationship did not change with practice. Increased 1/f intercept and a steeper 1/f slope were associated with higher perceptual sensitivity, measured as d′. However, this association was only observed under the highest levels of perceptual demand and only in the initial exposure to these conditions. Individuals with a lower 1/f intercept and a shallower 1/f slope demonstrated the greatest gains in perceptual sensitivity from task practice. These findings demonstrate that individual differences in motor and perceptual performance can be accounted for with resting-state aperiodic neural dynamics. The 1/f aperiodic parameters are most informative in predicting visuomotor performance under complex and demanding task conditions. In addition to predicting capacity for high visuomotor performance with a novel task, 1/f aperiodic parameters might also be useful in predicting which individuals might derive the most improvements from practice.

show abstract

Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Resting-state aperiodic neural dynamics predict individual differences in visuomotor performance and learning

Immink

Cross

Chatburn

et al. 2021

Preprint

View full text Add to dashboard Cite

show abstract

“…We cannot infer how these changes would manifest in a clinical population, or how they would impact potential clinical outcome. However, changes in cortical excitability, similar to our observed effect, have been linked to changes in mood, attention, and cognitive performance in both healthy (28,104) and patient populations (105,106). Thus, while our findings do provide a model of escitalopram-induced changes in cortical EIB, future studies or existing datasets (107-109) should investigate whether SSRI-induced EIB changes early in treatment could predict outcomes in clinical environments.…”

Section: Discussionsupporting

confidence: 63%

One-week escitalopram intake shifts excitation-inhibition balance in the healthy female brain

Zsido

Cesnaite

et al. 2021

Preprint

View full text Add to dashboard Cite

Neural health relies on cortical excitation-inhibition balance (EIB), with disrupted EIB underlying circuit dysfunction in several neuropsychiatric disorders. Previous research suggests links between increased cortical excitation and neuroplasticity induced by selective serotonin reuptake inhibitors (SSRIs). Whether there are modulations of EIB following SSRI-administration in the healthy human brain, however, remains unclear. To this end, we assessed changes in EIB following longitudinal escitalopram-intake. In a randomized, double-blind study protocol, a sample of 59 healthy female individuals on oral contraceptives underwent three resting-state electroencephalography recordings after daily administration of 20 mg escitalopram (n = 28) or placebo (n = 31) at baseline, after single dose, and after 1 week (steady state). We assessed 1/f slope of the power spectrum, a marker of EIB, compared individual trajectories of 1/f slope changes contrasting single dose and 1-week drug intake, and tested the relationship of escitalopram plasma levels and cortical excitatory and inhibitory balance shifts. Escitalopram-intake associated with decreased 1/f slope, indicating an EIB shift in favor of excitation. Furthermore, 1/f slope at baseline and after single dose of escitalopram predicted 1/f slope at steady state. Higher plasma escitalopram levels at single dose associated with better maintenance of these EIB changes throughout the drug administration week. Characterizing changes in 1/f slope during longitudinal SSRI-intake in healthy female individuals, we show that escitalopram shifted EIB in favor of excitation. These findings demonstrate the potential for 1/f slope to predict individual cortical responsivity to SSRIs and widen the neuroimaging lens by testing an interventional psychopharmacological design in a clearly-defined endocrinological state.

show abstract

In Utero Exposure to Alcohol and Tobacco and Electroencephalogram Power During Childhood

Pini,

Sania,

Rao

et al. 2024

JAMA Netw Open

View full text Add to dashboard Cite

ImportancePrenatal alcohol exposure (PAE) and prenatal tobacco exposure (PTE) are risk factors associated with adverse neurobehavioral and cognitive outcomes.ObjectiveTo quantify long-term associations of PAE and PTE with brain activity in early and middle childhood via electroencephalography (EEG).Design, Setting, and ParticipantsThis cohort study included participants enrolled in the Safe Passage Study (August 2007 to January 2015), from which a subset of 649 participants were followed up in the Environmental Influences on Child Health Outcomes Program. From September 2018 through November 2022, EEG recordings were obtained at ages 4, 5, 7, 9, or 11 years. Data were analyzed from November 2022 to November 2023.ExposuresMaternal self-reported consumptions of alcohol and tobacco during pregnancy were captured at the recruitment interview and at up to 3 visits during pregnancy (20-24, 28-32, and ≥34 weeks’ gestation). Classifications of PAE (continuous drinking, quit-early drinking, and nondrinking) and PTE (continuous smoking, quit-early smoking, and nonsmoking) were previously obtained.Main Outcomes and MeasuresEEG band powers (theta, alpha, beta, gamma) were extracted from the EEG recordings. Linear regression models were used to estimate the associations of PAE and PTE with EEG estimates.ResultsThe final sample included 649 participants (333 [51.3%] female) aged 4, 5, 7, 9, or 11 years. Children whose mothers were in the quit-early drinking cluster had increased alpha power (0.116 [95% CI, 0.023 to 0.209] μV2; P = .02) compared with individuals without PAE. The magnitude of this increase was approximately double for children exposed to continuous drinking (0.211 [95% CI, 0.005 to 0.417] μV2; P = .04). Children whose mothers were in the continuous smoking cluster had decreased beta power (−0.031 [95% CI, −0.059 to −0.003] μV2; P = .03) and gamma power (−0.020 [95% CI, −0.039 to −0.000] μV2; P = .04) compared with the nonsmoking cluster. In exploratory sex-stratified models, male participants in the quit-early PAE cluster had greater EEG power in the alpha band (0.159 [95% CI, 0.003 to 0.315] μV2; P = .04) compared with those with no PAE, and the difference was approximately double for male participants with continuous PAE (0.354 [95% CI, 0.041 to 0.667] μV2; P = .03). Male participants in the continuous PTE cluster had decreased beta (−0.048 [95% CI, −0.090 to − 0.007] μV2; P = .02) and gamma (−0.032 [95% CI, −0.061 − 0.002] μV2; P = .04) power compared with those with no PTE.Conclusions and RelevanceThese findings suggest that even low levels of PAE and PTE were associated with long-term alterations of brain activity.

show abstract

Behavioral and cognitive correlates of the aperiodic (1/f-like) exponent of the EEG power spectrum in adolescents with and without ADHD

Cited by 95 publications

References 60 publications

Resting-state aperiodic neural dynamics predict individual differences in visuomotor performance and learning

Resting-state aperiodic neural dynamics predict individual differences in visuomotor performance and learning

One-week escitalopram intake shifts excitation-inhibition balance in the healthy female brain

In Utero Exposure to Alcohol and Tobacco and Electroencephalogram Power During Childhood

Contact Info

Product

Resources

About