Behavioral and biochemical effects of chronic ? 9-tetrahydrocannabinol in rats

Miczek, Klaus A.; Dixit, Balwant N.

doi:10.1007/bf00431977

Cited by 40 publications

(10 citation statements)

References 36 publications

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“…and B.W.s during the treatment period. Our data are in agreement with previous studies showing that chronic administration of THC (Manning et al 1971;Miczek and Dixit 1980) and acute administration of CP 55,940 (McGregor et al 1996) inhibit F.I. and B.W.…”

Section: Discussionsupporting

confidence: 96%

Chronic treatment with CP 55,940 during the peri-adolescent period differentially affects the behavioural responses of male and female rats in adulthood

et al. 2003

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Section: Discussionsupporting

confidence: 96%

Chronic treatment with CP 55,940 during the peri-adolescent period differentially affects the behavioural responses of male and female rats in adulthood

et al. 2003

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“…Nevertheless, our electrophysiological experiments revealed a significantly elevated mean DR 5-HT neural activity in FAAH À/À mice that could provide the neurochemical substrate by which anxiolytic-like and antidepressant-like reactivity may be conveyed. Such an impact on 5-HT activity has been observed earlier with URB597 (Gobbi et al, 2005) and a low dose of the CB 1 R agonist, WIN55,212-2 (Bambico et al, 2007), and is consistent with the reported augmentation of the postsynaptic 5-HT content by cannabinoid agonists (Miczek and Dixit, 1980;Holtzman et al, 1969;Sagredo et al, 2006) or URB597 (Gobbi et al, 2005). This increase in 5-HT neural activity has been reliably replicated in other transgenic models of depression and antidepressant activity.…”

Section: Discussionsupporting

confidence: 87%

Genetic Deletion of Fatty Acid Amide Hydrolase Alters Emotional Behavior and Serotonergic Transmission in the Dorsal Raphe, Prefrontal Cortex, and Hippocampus

Bambico

Cassano

Domínguez-López

et al. 2010

Neuropsychopharmacol

117

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Pharmacological blockade of the anandamide-degrading enzyme, fatty acid amide hydrolase (FAAH), produces CB 1 receptor (CB 1 R)-mediated analgesic, anxiolytic-like and antidepressant-like effects in murids. Using behavioral and electrophysiological approaches, we have characterized the emotional phenotype and serotonergic (5-HT) activity of mice lacking the FAAH gene in comparison to their wild type counterparts, and their response to a challenge of the CB 1 R antagonist, rimonabant.

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“…For example, exposure to a regimen of THC that produces sensitization has been shown to increase the number of cannabinoid CB1 receptors in the cerebellum and to increase G-protein activation in the caudate-putamen and cerebellum (Rubino et al, 2003). Chronic administration of THC has also been shown to produce changes in brain levels of met-enkephalin, substance-P, b-endorphin and serotonin (Miczek and Dixit, 1980;Kumar et al, 1990) that could underlie differences in sensitivity to heroin between rats pre-exposed to THC and control rats pre-exposed to only vehicle. Also, THC is reported to produce anxiogenic effects at high doses (Chaperon and Thiebot, 1999).…”

Section: Discussionmentioning

confidence: 99%

Exposure to Δ-9-Tetrahydrocannabinol (THC) Increases Subsequent Heroin Taking but not Heroin's Reinforcing Efficacy: A Self-Administration Study in Rats

Solinas¹,

Panlilio²,

Goldberg³

2004

Neuropsychopharmacol

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One concern about the widespread use of cannabis is that exposure to its active ingredient, D-9-tetrahydrocannabinol (THC), might increase future reinforcing effects of other abused drugs such as heroin. In this study, we investigated the effects of pre-exposure to THC on subsequent intravenous self-administration of heroin by Sprague-Dawley rats. In one group of rats, we studied (1) acquisition of heroin self-administration behavior using a continuous-reinforcement (fixed-ratio (FR) 1) schedule, (2) heroin dose-response relationships using an FR1/variable-dose schedule, and (3) reinforcing efficacy of heroin using a progressive-ratio schedule. The number of rats pre-exposed to THC that subsequently learned to self-administer 50 mg/kg injections of heroin within 10 daily sessions did not differ from vehicle-pretreated controls. In contrast, rats pre-exposed to THC subsequently self-administered significantly more heroin injections per session and showed significantly shorter post-injection pauses over a range of heroin doses (12.5-100 mg/kg/injection) using the variable-dose schedule. Interestingly, the maximum effort rats would exert to receive an injection of the different doses of heroin under the progressive-ratio schedule was not altered by THC pre-exposure. In a second group of rats, we varied the 'price' of heroin (responses required/dose), by manipulating FR response requirements at different doses of heroin across sessions, to calculate demand and response output curves. Again, consumption was significantly higher in the THC-treated rats at the lowest prices of heroin (FR1/ 100 mg/kg and FR1/50 mg/kg) but there were no differences in the reinforcing efficacy of heroin between THC-and vehicle-pretreated rats. Altogether, these results demonstrate that pre-exposure to THC alters some pharmacological effects of heroin that determine frequency of heroin taking, but offer no support for the hypothesis that pre-exposure to THC alters heroin's efficacy as a reinforcer.

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Behavioral and biochemical effects of chronic ? 9-tetrahydrocannabinol in rats

Cited by 40 publications

References 36 publications

Chronic treatment with CP 55,940 during the peri-adolescent period differentially affects the behavioural responses of male and female rats in adulthood

Chronic treatment with CP 55,940 during the peri-adolescent period differentially affects the behavioural responses of male and female rats in adulthood

Genetic Deletion of Fatty Acid Amide Hydrolase Alters Emotional Behavior and Serotonergic Transmission in the Dorsal Raphe, Prefrontal Cortex, and Hippocampus

Exposure to Δ-9-Tetrahydrocannabinol (THC) Increases Subsequent Heroin Taking but not Heroin's Reinforcing Efficacy: A Self-Administration Study in Rats

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