Behavioral activation can normalize neural hypoactivation in subthreshold depression during a monetary incentive delay task

Mori, Asako; Okamoto, Yasumasa; Okada, Go; Takagaki, Keiichi; Jinnin, Ran; Takamura, Masahiro; Kobayakawa, Makoto; Yamawaki, Shigeto

doi:10.1016/j.jad.2015.09.036

Cited by 37 publications

(32 citation statements)

References 67 publications

(71 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our previous study demonstrated that BA for subthreshold depression leads to functional changes in the left ventrolateral prefrontal cortex (PFC) and angular gyrus during loss anticipation in a monetary incentive task (Mori et al 2016). …”

Section: Introductionmentioning

confidence: 99%

Effects of behavioural activation on the neural basis of other perspective self-referential processing in subthreshold depression: a functional magnetic resonance imaging study

et al. 2016

View full text Add to dashboard Cite

BackgroundIt has been demonstrated that negatively distorted self-referential processing, in which individuals evaluate one's own self, is a pathogenic mechanism in subthreshold depression that has a considerable impact on the quality of life and carries an elevated risk of developing major depression. Behavioural activation (BA) is an effective intervention for depression, including subthreshold depression. However, brain mechanisms underlying BA are not fully understood. We sought to examine the effect of BA on neural activation during other perspective self-referential processing in subthreshold depression.MethodA total of 56 subjects underwent functional magnetic resonance imaging scans during a self-referential task with two viewpoints (self/other) and two emotional valences (positive/negative) on two occasions. Between scans, while the intervention group (n = 27) received BA therapy, the control group (n = 29) did not.ResultsThe intervention group showed improvement in depressive symptoms, increased activation in the dorsal medial prefrontal cortex (dmPFC), and increased reaction times during other perspective self-referential processing for positive words after the intervention. Also, there was a positive correlation between increased activation in the dmPFC and improvement of depressive symptoms. Additionally, there was a positive correlation between improvement of depressive symptoms and increased reaction times.ConclusionsBA increased dmPFC activation during other perspective self-referential processing with improvement of depressive symptoms and increased reaction times which were associated with improvement of self-monitoring function. Our results suggest that BA improved depressive symptoms and objective monitoring function for subthreshold depression.

show abstract

Section: Introductionmentioning

confidence: 99%

Effects of behavioural activation on the neural basis of other perspective self-referential processing in subthreshold depression: a functional magnetic resonance imaging study

et al. 2016

View full text Add to dashboard Cite

show abstract

“…As is known, the VLPFC is considered to be negatively correlated with negative affect [32] and inhibitive controls of negative emotions and cognitions, such as reappraisal [33]. Meanwhile, a recent research showed that depression patients had decreased activation of left VLPFC compared to normal controls when processing negative information such as loss [34]. Furthermore, decreased ALFF values in the left VLPFC were negatively correlated to the HDRS score of D-SAPHO patients in our study, which suggested that ALFF measurement in left VLPFC would be a good marker to detect and evaluate the severity of depression in SAPHO patients.…”

Section: Discussionmentioning

confidence: 99%

Depression in patients with SAPHO syndrome and its relationship with brain activity and connectivity

Duan

Zuo

et al. 2017

Orphanet J Rare Dis

View full text Add to dashboard Cite

BackgroundSynovitis-acne-pustulosis-hyperostosis-osteitis (SAPHO) syndrome is a rare disease and there is no related literature concerning psychiatric symptoms in SAPHO patients. Thus, we believe that this will be the first paper to explore the episode and the neurobiological basis of depression symptoms in SAPHO patients using resting state functional magnetic resonance imaging (rs-fMRI). Twenty-eight SAPHO patients and fifteen age- and gender- matched normal controls (NC) were consecutively submitted to psychiatric evaluation and rs-fMRI scanning.Results46.2% (13/28) of SAPHO patients were diagnosed as depression. The local spontaneous activity study showed that depressed SAPHO (D-SAPHO) patients had decreased amplitude of low-frequency fluctuation (ALFF) in the bilateral ventrolateral prefrontal cortex (VLPFC, attributed to the anatomical structures of Brodmann’s area 47, 45 and 44) and right dorsolateral prefrontal cortex (DLPFC, attributed to the anatomical structures of Brodmann’s area 8, 9 and 46), increased ALFF in the bilateral middle temporal gyrus, when compared to non-depressed SAPHO (ND-SAPHO) patients. The functional connectivity (FC) study disclosed that D-SAPHO patients had an increased FC in the anterior portions of default mode network (DMN) (the bilateral inferior frontal cortex, anterior cingulate cortex and insula cortex), and a decreased FC in the posterior areas of DMN (left middle occipital cortex), when compared to ND-SAPHO patients. Furthermore, correlation analysis revealed that both ALFF and FC values were significantly correlated with depression scores of SAPHO patients.ConclusionThese results prompt us to understand the underlying pathophysiological mechanism of depression in SAPHO syndrome, and demonstrate that abnormal brain functional areas may serve as effective biological indicators to monitor depression in the future.Electronic supplementary materialThe online version of this article (doi:10.1186/s13023-017-0658-5) contains supplementary material, which is available to authorized users.

show abstract

“…Dimidjian et al [72] indicated that treatment effects of behavioral activation are comparable in efficacy to pharmacological therapy for individuals suffering from depression. Our previous studies reported that behavioral activation improved abilities both to access positive reinforcing activities and to engage in rewarding behaviors under adverse circumstances [73,74]. Additionally, Jacobson et al [69] showed behavioral activation significantly improved self-concept in people with depression.…”

Section: Theoretical Framework and Practical Evidence Of Behavioral Amentioning

confidence: 95%

Dynamic and Static Models of Body-Mind Approaches from Neurobiological Perspectives

Shiota¹,

Nomura²

2019

Neuroethics in Principle and Praxis - Conceptual Foundations

View full text Add to dashboard Cite

Body-mind approaches (e.g., yoga, mindfulness meditation, Pilates method, and cognitive behavior therapy) are commonly used by the public today. However, the comprehensive neurobiological framework of effects of body-mind approaches is unknown. To begin, we discuss the dynamic and static models of each body-mind approaches from neurobiological perspectives, as well as from the standpoint of practical issues. By the dynamic components of body-mind approaches, people enhances meta-cognitive function, and it lead to decreases in avoidance behavior in social aversive context are suggested. On the other hand, it is assumed that static components of body-mind approaches enhance non-reactive monitoring function for baseline of self. Therefore, we discuss the implications of these findings for practitioners and for future research on body-mind researchers. Additionally, this chapter covers the essential ethical guidelines of body-mind approaches within the domain of medical or educational fields.

show abstract

Behavioral activation can normalize neural hypoactivation in subthreshold depression during a monetary incentive delay task

Cited by 37 publications

References 67 publications

Effects of behavioural activation on the neural basis of other perspective self-referential processing in subthreshold depression: a functional magnetic resonance imaging study

Effects of behavioural activation on the neural basis of other perspective self-referential processing in subthreshold depression: a functional magnetic resonance imaging study

Depression in patients with SAPHO syndrome and its relationship with brain activity and connectivity

Dynamic and Static Models of Body-Mind Approaches from Neurobiological Perspectives

Contact Info

Product

Resources

About