Behavior of radial forearm skin flaps transplanted into the oral cavity

Badran, Darwish H.; Soutar, David S.; Robertson, Anne S.; Reid, O.; Milne, E.W.; McDonald, Stuart W.; Scothorne, R. J.

doi:10.1002/(sici)1098-2353(1998)11:6<379::aid-ca3>3.0.co;2-h

Cited by 32 publications

(36 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…3Y5 In relation to the factors that correlate with flap morphology changes, when Bardan et al examined 53 patients who had undergone flap surgery, they found that more than half of the patients who received postoperative radiotherapy demonstrated gross changes in the flap. 10 These changes correlated significantly with tissue transfer, irradiation, and Candida infection. However, permanent changes such as mucosal metaplasia were not observed.…”

Section: Discussionmentioning

confidence: 99%

Analysis of Morphological and Histologic Changes in Intraoral Fasciocutaneous Free Flaps Used for Oropharyngeal Reconstruction

Choi

Kim²,

Park³

et al. 2014

Annals of Plastic Surgery

View full text Add to dashboard Cite

The fasciocutaneous flap transplanted into the oral cavity often acquires a gross appearance resembling that of intraoral mucosa. The purpose of this study was to analyze the histologic and morphological changes of the fasciocutaneous free flap in oropharyngeal reconstruction and attempt to determine the related causes. A study was done from January 2006 to February 2010. Study subjects included 67 of 239 patients who had undergone reconstructive surgery after oropharyngeal tumor resection. Histologic evaluation of biopsy specimens was also performed in 20 patients. The correlation of the morphological changes with various factors was analyzed. The histologic examination revealed that numerous histologic changes occurred although the overall structure of the skin was maintained. Analysis of the associated factors showed that the primary defect site was highly correlated with this morphological change in the intraoral flaps.Analysis of the associated factors showed that the primary defect site was highly correlated with this morphological change in the intraoral flaps. Histologic analysis reveals that fasciocutaneous free flaps maintain their feature as cutaneous skin yet undergo changes because of the characteristic oral cavity environment, which resulted in an intermediate-stage morphology.

show abstract

Section: Discussionmentioning

confidence: 99%

Analysis of Morphological and Histologic Changes in Intraoral Fasciocutaneous Free Flaps Used for Oropharyngeal Reconstruction

Choi

Kim²,

Park³

et al. 2014

Annals of Plastic Surgery

View full text Add to dashboard Cite

show abstract

“…12 Drawbacks to the use of skin flaps include donor site defects, bulkiness and hair bearing of flaps. 1 Alternative reconstructive approaches using cultured mucosa as a substitute are being developed. 10 These involve the culture of keratinocytes and subsequent combination of these cells with a biomaterial that serves as a dermal carrier.…”

mentioning

confidence: 93%

Mucosal keratinocyte isolation: a short comparative study on thermolysin and dispase

Rakhorst

Tra

Sluijs

et al. 2006

International Journal of Oral and Maxillofacial Surgery

View full text Add to dashboard Cite

“…Several methods are available nowadays to assess the clonal relationship between two lesions. Clonal assessment by mtDNA analysis 29 is based on the concept that mitochondrial DNA is present in high copy number in each cell (10 3 –10 4 ) and that the vast majority of these copies are identical at birth (homoplasmic). In other words, neoplastic cells preserve the high copy number but show a high frequency of mutations in the mtDNA, especially in the D‐loop region.…”

Section: Discussionmentioning

confidence: 99%

“…Indeed, diseases typically affecting the skin, such as psoriasis 31 and focal acantholytic dyskeratosis, 32 have been reported in skin grafts. Therefore, it is not implausible to consider that skin grafted into the oral cavity may retain its ability to produce cytokines, continuing to give instructive signals 4 …”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Cancerization of cutaneous flap reconstruction for oral squamous cell carcinoma: report of three cases studied with the mtDNA D‐loop sequence analysis

et al. 2011

View full text Add to dashboard Cite

Foschini M P, Morandi L, Marchetti C, Cocchi R, Eusebi L H, Farnedi A, Badiali G, Gissi D B, Pennesi M G & Montebugnoli L (2011) Histopathology58, 361–367 Cancerization of cutaneous flap reconstruction for oral squamous cell carcinoma: report of three cases studied with the mtDNA D‐loop sequence analysis Aims: Tissue defects, resulting from surgical resection of oral squamous cell carcinoma (OSCC), are reconstructed routinely with skin grafts. OSCC arising from the grafted skin has been described; however, it is still unclear whether primary and second tumours have a common clonal origin. The aim of this study was to evaluate the clonal relationship between the primary OSCC and secondary neoplastic changes appearing in the skin graft in three patients, by screening the mitochondrial DNA D‐loop region (mtDNA). Methods and results: In all three cases, the neoplastic lesions arising in the skin graft showed a clonal relationship with the previous OSCC and, on the basis of the results obtained by mtDNA analysis, could be considered to be a recurrence of the primary OSCC rather than a second primary OSCC. Conclusions: Starting from a field of genetically altered cells in the oral mucosa, the spread of the clonal cell population to the cutaneous flap might be stimulated by cytokines produced by the grafted skin. More studies are needed to evaluate the molecular relationship between primary and second OSCC to identify patients at higher risk of developing a second tumour in the skin graft.

show abstract

Behavior of radial forearm skin flaps transplanted into the oral cavity

Cited by 32 publications

References 9 publications

Analysis of Morphological and Histologic Changes in Intraoral Fasciocutaneous Free Flaps Used for Oropharyngeal Reconstruction

Analysis of Morphological and Histologic Changes in Intraoral Fasciocutaneous Free Flaps Used for Oropharyngeal Reconstruction

Mucosal keratinocyte isolation: a short comparative study on thermolysin and dispase

Cancerization of cutaneous flap reconstruction for oral squamous cell carcinoma: report of three cases studied with the mtDNA D‐loop sequence analysis

Contact Info

Product

Resources

About