Behavior of In Situ Cross‐Linked Hydrogels with Rapid Gelation Kinetics on Contact with Physiological Fluids

Diryak, Ramadan; Kontogiorgos, Vassilis; Ghori, Muhammad Usman; Bills, Paul J.; Tawfik, Ahmed Y.; Morris, Gordon A.; Smith, Alan M.

doi:10.1002/macp.201700584

Cited by 12 publications

(9 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Gʹ and Gʹʹ at this stage were very low (~0.6 Pa), indicative of an entangled polymer solution. When the formulation was exposed to 0.1M HCl (pH 1.2), by injecting the simulated gastric fluid into the rheo-dissolution system, there was an almost instantaneous increase in Gʹ of almost 3 orders of magnitude, similar to that what was previously reported by Diryak et al (2018) (Diryak et al, 2018) and is in line with expected behaviour ( fig. 6A).…”

Section: Rheo-dissolution Measurements For In Situ Gel Forming Oral Fsupporting

confidence: 87%

“…The rate of drug release therefore, is strongly related to the mechanical properties that include gelation kinetics, gel strength and gel dissolution (Mahdi, Conway, & Smith, 2014). In situ sol-gel transitions can take place as a result of changes in temperature as occurs with polymers such as methylcellulose (Bain, Bhowmik, Ghosh, & Chattopadhyay, 2009), poloxamer (Amiji, Lai, Shenoy, & Rao, 2002;Edsman, Carlfors, & Petersson, 1998) or PLGA (He, Kim, & Lee, 2008) by changes in pH and/or presence of electrolytes Carbopol ® (Srividya, Cardoza, & Amin, 2001), gellan gum (Diryak et al, 2018;Rajinikanth & Mishra, 2008), alginate (Miyazaki, Kubo, & Attwood, 2000), pectin (Kubo, Konno, Miyazaki, & Attwood, 2004), and carrageenan (Endo, Watanabe, Matsumoto, & Shirotake, 2000). During development, thermal transitions can be accurately measured using a temperature-controlled rheometer.…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, sodium alginate undergoes a similarly rapid transition in acidic media such as gastric fluid, forming an alginic acid gel. Recently in our laboratories we have demonstrated the experimental monitoring of the external gelation of alginate by modifying a commercially available rheometer (Mahdi, Diryak, Kontogiorgos, Morris, & Smith, 2016) and have since adapted this modification as an experimental simulation of gelation on contact with various physiological fluids (Diryak et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Rheo-dissolution: A new platform for the simultaneous measurement of rheology and drug release

Senjoti

Ghori

Diryak

et al. 2020

Carbohydrate Polymers

Self Cite

View full text Add to dashboard Cite

There is great potential to improve drug delivery through the use of in-situ gelling delivery systems. Here we demonstrate a technique capable of measuring changes in rheology (gelation and/or dissolution) of in-situ gelling delivery systems on contact with physiological fluid, while simultaneously analysing drug release. An ocular in-situ gelling formulation (gellan and timolol maleate) and an in-situ gelling oral liquid (alginate and metronidazole) were used as exemplar formulations. The method allowed profiling of increasing gellan concentration resulting in a reduction of timolol maleate released into simulated lacrimal fluid. When alginate was used as an in-situ gelling oral formulation there was a rapid increase in Gʹ on contact with simulated gastric fluid. When this was changed to simulated intestinal fluid, drug release rate increased rapidly, coinciding with alginate gel dissolution. This work highlights the potential of this technology as a tool in development and optimisation of these increasingly popular delivery systems.

show abstract

Section: Rheo-dissolution Measurements For In Situ Gel Forming Oral Fsupporting

confidence: 87%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Rheo-dissolution: A new platform for the simultaneous measurement of rheology and drug release

Senjoti

Ghori

Diryak

et al. 2020

Carbohydrate Polymers

Self Cite

View full text Add to dashboard Cite

show abstract

“…3D parametric surface texture analysis of printed formulations was examined using Talysurf CCI 3000 optical 3D surface profiler and the method was adopted as previously described [ 28 ]. Briefly, printed tablets placed on a clean stainless steel stage using double-sided transparent tape and 1.2 × 1.2 mm 2 area was scanned and then 3D parametric surface texture parameters were determined using MATLAB 2017 (The Math Works, Inc. Natick, Massachusetts, USA) [ 28 , 32 , 33 , 34 ].…”

Section: Methodsmentioning

confidence: 99%

Personalised 3D Printed Fast-Dissolving Tablets for Managing Hypertensive Crisis: In-Vitro/In-Vivo Studies

et al. 2020

View full text Add to dashboard Cite

Hypertensive crisis (HC) is an emergency health condition which requires an effective management strategy. Over the years, various researchers have developed captopril based fast-dissolving formulations to manage HC; however, primarily, the question of personalisation remains unaddressed. Moreover, commercially these formulations are available as in fixed-dose combinations or strengths, so the titration of dose according to patient’s prerequisite is challenging to achieve. The recent emergence of 3D printing technologies has given pharmaceutical scientists a way forward to develop personalised medicines keeping in view patients individual needs. The current project, therefore, is aimed at addressing the limitations as mentioned above by developing fast-dissolving captopril tablets using 3D printing approach. Captopril unloaded (F1) and loaded (F2-F4) filaments were successfully produced with an acceptable drug loading and mechanical properties. Various captopril formulations (F2–F4) were successfully printed using fused deposition modelling technique. The results revealed that the formulations (F2 and F3) containing superdisintegrant had a faster extent of dissolution and in-vivo findings were endorsing these results. The present study has successfully exhibited the utilisation of additive manufacturing approach to mend the gap of personalisation and manufacturing fast-dissolving captopril 3D printed tablets. The procedure adopted in the present study may be used for the development of fused deposition modelling (FDM) based fast-dissolving 3D printed tablets.

show abstract

“…The previously weighed baskets, containing hydrated matrix tablets, were removed at different time points, lightly blotted with 125 mm filter paper (Whatman®, Maidstone, Kent, UK) to remove excess liquid, reweighed ( W s ) and were rapidly replaced back into the swelling media in dissolution apparatus. The mean weight was determined for each formulation and degree of swelling (S) was calculated by using Equation 1) [36,37,38,39]. S=Ws−WiWi×100 where W i and W s are the initial dry and swollen weight of the matrix tablet, respectively, at immersion time (t) in the swelling media.…”

Section: Methodsmentioning

confidence: 99%

Plasticiser-Free 3D Printed Hydrophilic Matrices: Quantitative 3D Surface Texture, Mechanical, Swelling, Erosion, Drug Release and Pharmacokinetic Studies

et al. 2019

View full text Add to dashboard Cite

Hydroxypropyl methyl cellulose, HPMC, a hydrophilic polymer, is widely used for the development of extended release hydrophilic matrices and it is also considered as a good contender for the fabrication of 3D printing of matrix tablets. It is often combined with plasticisers to enable extrusion. The aim of the current project was to develop plasticizer-free 3D printed hydrophilic matrices using drug loaded filaments prepared via HME to achieve an in vitro (swelling, erosion and drug release) and in vivo (drug absorption) performance which is analogous to hydrophilic matrix tablets developed through conventional approaches. Additionally, the morphology of the printed tablets was studied using quantitative 3D surface texture studies and the porosity calculated. Filaments were produced successfully and used to produce matrix tablets with acceptable drug loading (95–105%), mechanical and surface texture properties regardless of the employed HPMC grade. The viscosity of HPMC had a discernible impact on the swelling, erosion, HPMC dissolution, drug release and pharmacokinetic findings. The highest viscosity grade (K100M) results in higher degree of swelling, decreased HPMC dissolution, low matrix erosion, decreased drug release and extended drug absorption profile. Overall, this study demonstrated that the drug loaded (glipizide) filaments and matrix tablets of medium to high viscosity grades of HPMC, without the aid of plasticisers, can be successfully prepared. Furthermore, the in vitro and in vivo studies have revealed the successful fabrication of extended release matrices.

show abstract

Behavior of In Situ Cross‐Linked Hydrogels with Rapid Gelation Kinetics on Contact with Physiological Fluids

Cited by 12 publications

References 33 publications

Rheo-dissolution: A new platform for the simultaneous measurement of rheology and drug release

Rheo-dissolution: A new platform for the simultaneous measurement of rheology and drug release

Personalised 3D Printed Fast-Dissolving Tablets for Managing Hypertensive Crisis: In-Vitro/In-Vivo Studies

Plasticiser-Free 3D Printed Hydrophilic Matrices: Quantitative 3D Surface Texture, Mechanical, Swelling, Erosion, Drug Release and Pharmacokinetic Studies

Contact Info

Product

Resources

About