Behavior of chronically decerebrated kittens

Bignall, KE; Schramm, Lawrence P.

doi:10.1016/0014-4886(74)90075-2

Cited by 56 publications

(15 citation statements)

References 12 publications

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“…The righting reflex of neonatal rats is organized caudally in the brainstem, with more rostral controls exerting a modulating influence with increasing maturation (Bignall, 1974). The behavioral repertoire of decerebrate kittens is remarkably normal, and develops with an ontogenetic time course similar to that of intact kittens (Bignall & Schramm, 1974).…”

Section: Discussionmentioning

confidence: 97%

Kinematic analyses of air-stepping in normal and decerebrate preweanling rats

Stehouwer

Hartesveldt

2000

Dev. Psychobiol.

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Section: Discussionmentioning

confidence: 97%

Kinematic analyses of air-stepping in normal and decerebrate preweanling rats

Stehouwer

Hartesveldt

2000

Dev. Psychobiol.

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“…Indeed, without intact basal ganglia, cats and rats cannot lick for milk and water even though they are able to orient their heads and move toward auditory, olfactory, and tactile stimuli. These animals only show “reflexive” licking and chewing when food or milk is placed into contact with their lips 14, 15 .…”

Section: Introductionmentioning

confidence: 99%

A GABAergic nigrotectal pathway for coordination of drinking behavior

Rossi

et al. 2016

Nat Neurosci

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The contribution of basal ganglia outputs to consummatory behavior remains poorly understood. We recorded from the substantia nigra pars reticulata (SNR), the major basal ganglia output nucleus, during self-initiated drinking. The firing rates of many lateral SNR neurons were time-locked to individual licks. These neurons send GABAergic projections to the deep layers of the orofacial region of the lateral tectum (superior colliculus, SC). Many tectal neurons are also time-locked to licking, but their activity is usually antiphase to that of SNR neurons, suggesting inhibitory nigrotectal projections. We used optogenetics to selectively activate the GABAergic nigrotectal afferents in the deep layers of the SC. Photo-stimulation of the nigrotectal projections transiently inhibited the activity of the lick-related tectal neurons, disrupted their licking-related oscillatory pattern, and suppressed self-initiated drinking. These results demonstrate that GABAergic nigrotectal projections play a crucial role in coordinating drinking behavior.

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“…Chronic decerebrates, such as mesencephalic cats or rats, upon nociceptive stimulation, exhibit crying, fear and the escape response; they also express elements of rage behavior 20,21. Decerebrate kittens can develop many behavioral patterns closely parallel with that of normal animals 22. These experiments indicate that the brain stem could organize and execute species-typical behaviors and partly even meaningful patterns of behavior 20.…”

Section: Introductionmentioning

confidence: 81%

Appearance of fetal pain could be associated with maturation of the mesodiencephalic structures

Sekulić¹,

Gebauer-Bukurov²,

Cvijanović³

et al. 2016

JPR

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Fetal pain remains a controversial subject both in terms of recognizing its existence and the time-frame within which it appears. This article investigates the hypothesis that pain perception during development is not related to any determined structures of the central nervous system (CNS), on the contrary, the process of perception could be made with any structure satisfying conditions that the perception of pain is the organization, identification, and interpretation of sensory information in order to represent and understand the environment. According to this definition, chronic decerebrate and decorticate experimental animals, anencephalic, and hydranencephalic patients demonstrate that the basic, most general, appropriate interaction with the environment can be achieved with a functional mesodiencephalon (brain stem, and diencephalon) as the hierarchically highest structure of the CNS during development. In intact fetuses, this structure shows signs of sufficient maturation starting from the 15th week of gestation. Bearing in mind the dominant role of the reticular formation of the brain stem, which is marked by a wide divergence of afferent information, a sense of pain transmitted through it is diffuse and can dominate the overall perception of the fetus. The threshold for tactile stimuli is lower at earlier stages of gestation. The pain inhibition mechanisms are not sufficiently developed during intrauterine development, which is another factor that leads to increased intensity of pain in the fetus. As a conclusion it could be proposed that the fetus is exposed to rudimentary painful stimuli starting from the 15th gestation week and that it is extremely sensitive to painful stimuli.

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Behavior of chronically decerebrated kittens

Cited by 56 publications

References 12 publications

Kinematic analyses of air-stepping in normal and decerebrate preweanling rats

Kinematic analyses of air-stepping in normal and decerebrate preweanling rats

A GABAergic nigrotectal pathway for coordination of drinking behavior

Appearance of fetal pain could be associated with maturation of the mesodiencephalic structures

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