Behavior of C-reactive protein levels in medically treated aortic dissection and intramural hematoma

Makita, Shinji; Ohira, Atsushi; Tachieda, Rintarou; Itoh, Shigehiro; Moriai, Yoshiteru; Yoshioka, Kunihiro; Niinuma, Hiroyuki; Nakamura, Motoyuki; Hiramori, Katsuhiko

doi:10.1016/s0002-9149(00)00869-9

Cited by 38 publications

(28 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…3 The biochemical methods for diagnosing acute myocardial infarction (AMI) have advanced greatly in the past quarter century; these methods include the use of creatinine phosphokinase (CK), the MB isozyme of CK, 4 cardiac myosin light chain, 5 troponin T, 6 and human heart fatty acid binding protein. 7,8 Meanwhile, for the diagnosis of AAD, smooth muscle myosin heavy chain 9,10 and C-reactive protein (CRP) 11 in the serum have both been reported to be such candidates. However, they also have several drawbacks: the former rapidly disappears within the first 12 hours after onset, 9,10 whereas the levels of the latter, which is a nonspecific marker of inflammation, begin to increase only the day after onset.…”

Section: See Page 1721mentioning

confidence: 99%

“…However, they also have several drawbacks: the former rapidly disappears within the first 12 hours after onset, 9,10 whereas the levels of the latter, which is a nonspecific marker of inflammation, begin to increase only the day after onset. 11 Therefore, the establishment and clinical availability of another simplified laboratory test(s) to help make a timely and accurate diagnosis of AAD is urgently needed.…”

Section: See Page 1721mentioning

confidence: 99%

See 1 more Smart Citation

Soluble Elastin Fragments in Serum Are Elevated in Acute Aortic Dissection

Shinohara

Suzuki

Okada

et al. 2003

ATVB

137

View full text Add to dashboard Cite

Objective-We aimed to establish an enzyme-linked immunosorbent assay for measuring soluble elastin fragments (sELAF) in serum and to reveal its usefulness in diagnosing acute aortic dissection (AAD). Methods and Results-An enzyme-linked immunosorbent assay to measure sELAF in serum was developed by using the newly created double monoclonal antibodies, which recognize the different epitopes of human aortic elastin. Twenty-five AAD patients, 50 patients with acute myocardial infarction (AMI), and 474 healthy individuals were enrolled in the study. The sELAF levels from healthy subjects gradually increased with aging. When the cutoff point for positivity was set at the meanϩ3 SD (ie, 3 SD above the mean in healthy subjects at each age), 16 AAD patients (64.0%) were found be positive, whereas only 1 AMI patient was found to be positive (2.0%). AAD patients with either an open or a partially open pseudolumen were found be 88.9% positive for sELAF, whereas those with its early closure were 0% positive. The difference in the sELAF levels between AAD patients with and without a thrombotic closure of false lumen was significant (60.3Ϯ15.6 versus 135.4Ϯ53.2 ng/mL, respectively; PϽ0.005). Key Words: matrix protein Ⅲ elastin degradation Ⅲ aortic media Ⅲ intimal tear Ⅲ false lumen A cute aortic dissection (AAD) is a life-threatening medical emergency of the aorta that is associated with a high mortality. In AAD patients who do not receive immediate treatment, mortality is estimated to be 35% within the initial 24 hours, 50% within 48 hours, and 80% after 2 weeks. 1 Conclusions-The

show abstract

Section: See Page 1721mentioning

confidence: 99%

Section: See Page 1721mentioning

confidence: 99%

Soluble Elastin Fragments in Serum Are Elevated in Acute Aortic Dissection

Shinohara

Suzuki

Okada

et al. 2003

ATVB

137

View full text Add to dashboard Cite

show abstract

“…Currently, most investigators believe that ischemia-reperfusion injury (IRI) and the release of massive amounts of inflammatory mediators during cardiopulmonary bypass (CPB) and circulatory arrest are responsible for ARDS after cardiac surgery (3)(4)(5)(6). Analysis of risk factors for and the prognosis of postoperative acute respiratory distress syndrome in patients with Stanford type A aortic dissection risks associated with these surgical procedures are therefore much greater than those of other types of AD (7).…”

Section: Introductionmentioning

confidence: 99%

Analysis of risk factors for and the prognosis of postoperative acute respiratory distress syndrome in patients with Stanford type A aortic dissection

2016

View full text Add to dashboard Cite

show abstract

“…5 Modifier genes such as 5,10-methylenetetrahydrofolate reductase (MTHFR) help to identify patients who have a high probability of developing severe manifestations of the disease. 8 Susceptibility genes, such as MTHFR, 9 metalloproteinase-9, 10 chemokine receptor 5 (CCR5) 11 5-lipoxygenase (5-LO), 12 carrying polymorphic mutations such as C677T MTHFR, C1562T MMP9, ∆32 CCR5, [11][12][13] predispose to abdominal aortic aneurysms (AAA) and/or atherosclerosis.…”

mentioning

confidence: 99%

“…An increase in the levels of C-reactive protein (CRP) indicates a high risk for short-term mortality in patients with acute dissection or intramural hematoma. 13 Smooth muscle myosin heavy chains (SMMHC), 14 creatine kinase BB (CK-BB) isozyme, 15 soluble elastin fragments (sELAF) 16 degraded through elastase and metalloproteinases (MMPs) help in early diagnosis, monitoring progression, and guiding therapy. 17 D-dimers at a concentration higher than 626 µg/l have been shown to differentiate reliably between acute and chronic aortic dissection with important prognostic and therapeutic implications.…”

mentioning

confidence: 99%