Behavior: Local Lateral Habenula Interneurons Mediate Aggression

Webster, Jack F.; Wozny, Christian

doi:10.1016/j.cub.2020.06.065

Cited by 3 publications

(2 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The habenula has been implicated in aggressive behaviors in rodents and fish ( Chou et al, 2016 ; Flanigan et al, 2017 ; Webster and Wozny, 2020 ). A functional magnetic resonance imaging in male patients with the symptom of intermittent explosive disorder (IED) shows a possible association between the habenula activity and the severity of aggressive behavior ( Gan et al, 2019 ).…”

Section: Role Of the Habenula In Social Behaviorsmentioning

confidence: 99%

Role of Habenula in Social and Reproductive Behaviors in Fish: Comparison With Mammals

Ogawa

Parhar

2022

Front. Behav. Neurosci.

View full text Add to dashboard Cite

Social behaviors such as mating, parenting, fighting, and avoiding are essential functions as a communication tool in social animals, and are critical for the survival of individuals and species. Social behaviors are controlled by a complex circuitry that comprises several key social brain regions, which is called the social behavior network (SBN). The SBN further integrates social information with external and internal factors to select appropriate behavioral responses to social circumstances, called social decision-making. The social decision-making network (SDMN) and SBN are structurally, neurochemically and functionally conserved in vertebrates. The social decision-making process is also closely influenced by emotional assessment. The habenula has recently been recognized as a crucial center for emotion-associated adaptation behaviors. Here we review the potential role of the habenula in social function with a special emphasis on fish studies. Further, based on evolutional, molecular, morphological, and behavioral perspectives, we discuss the crucial role of the habenula in the vertebrate SDMN.

show abstract

Section: Role Of the Habenula In Social Behaviorsmentioning

confidence: 99%

Role of Habenula in Social and Reproductive Behaviors in Fish: Comparison With Mammals

Ogawa

Parhar

2022

Front. Behav. Neurosci.

View full text Add to dashboard Cite

show abstract

“…The habenula (Hb) is an epithalamic structure that presents rich connections with several cortical and subcortical structures, including the limbic system, and areas responsible for the production and regulation of monoamines (i.e., raphe nuclei for serotonin, ventral tegmental area and substantia nigra for dopamine, and locus coeruleus for noradrenaline) ( 1 – 5 ). These connections place the Hb in a central position for the regulation of motivated behaviors, and thus has been implicated in the pathophysiology of several disorders, such as autism spectrum disorder (ASD) ( 6 ), depression ( 7 , 8 ), bipolar disorder ( 8 – 10 ), and schizophrenia ( 10 , 11 ), as well as neuropsychiatric symptoms, such as aggressive behaviors ( 12 , 13 ).…”

Section: Introductionmentioning

confidence: 99%

Habenula as a Neural Substrate for Aggressive Behavior

Gouveia

Ibrahim

2022

Front. Psychiatry

View full text Add to dashboard Cite

Over the past decades, an ever growing body of literature has explored the anatomy, connections, and functions of the habenula (Hb). It has been postulated that the Hb plays a central role in the control of the monoaminergic system, thus influencing a wide range of behavioral responses, and participating in the pathophysiology of a number of psychiatric disorders and neuropsychiatric symptoms, such as aggressive behaviors. Aggressive behaviors are frequently accompanied by restlessness and agitation, and are commonly observed in patients with psychiatric disorders, intellectual disabilities, and neurodegenerative diseases of aging. Recently, the Hb has been explored as a new target for neuromodulation therapies, such as deep brain stimulation, with promising results. Here we review the anatomical organization of the habenula and discuss several distinct mechanisms by which the Hb is involved in the modulation of aggressive behaviors, and propose new investigations for the development of novel treatments targeting the habenula to reduce aggressive behaviors.

show abstract

Functions of habenula in reproduction and socio-reproductive behaviours

Ogawa

Parhar

2022

Frontiers in Neuroendocrinology

View full text Add to dashboard Cite

Behavior: Local Lateral Habenula Interneurons Mediate Aggression

Cited by 3 publications

References 19 publications

Role of Habenula in Social and Reproductive Behaviors in Fish: Comparison With Mammals

Role of Habenula in Social and Reproductive Behaviors in Fish: Comparison With Mammals

Habenula as a Neural Substrate for Aggressive Behavior

Functions of habenula in reproduction and socio-reproductive behaviours

Contact Info

Product

Resources

About