Behavior in a Forced Swimming Test and Expression of the Genes for a Neurotrophic Factor (BDNF) and Antiapoptotic Protein Bcl-xl

Berezova, I. V.; Шишкина, Г. Т.; Kalinina, Tatyana; Дыгало, Н. Н.

doi:10.1007/s11055-012-9676-x

Cited by 3 publications

(1 citation statement)

References 29 publications

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“…While the study was designed as such, since we expected to see changes in these genes based on our previous findings in GluA1 knockout mice 18 as well as from findings in other studies, that suggested an important role of AMPA receptors in stress and depression 8 , it is more than likely that other targets will be effected. For example, expression of BDNF, mGluR5 and GluN1, among others, has been shown to be altered following forced swim stress 27,41,42 . Moreover, while we did not find changes in Gria2 levels, which is consistent with most studies investigating mRNA levels of this gene following stress exposure 12,14,16 , we did not measure protein levels of GluA2.…”

Section: Discussionmentioning

confidence: 99%

Quantitative analysis of Gria1, Gria2, Dlg1 and Dlg4 expression levels in hippocampus following forced swim stress in mice

Freudenberg

2019

Sci Rep

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AMPA receptors and interacting proteins are importantly involved in mediating stress-dependent plasticity. Previously we reported that GluA1-containing AMPA receptors and their interaction with PDZ-proteins are required for the experience-dependent expression of behavioral despair in the forced swim test. However, it is unclear if the expression of GluA1-containing AMPA receptors is affected by this type of behavior. Here we investigated in wild type mice, whether hippocampal gene or protein levels of GluA1 or associated PDZ proteins is altered following forced swim stress. We show that expression of Dlg4 (the gene coding for PSD-95) was strongly reduced after two days of forced swimming. In contrast, levels of Dlg1, Gria1, and Gria2 (coding for SAP97, GluA1, and GluA2 respectively) were not affected after one or two days of forced swimming. The changes in gene expression largely did not translate to the protein level. These findings indicate a limited acute effect of forced swim stress on the expression of the investigated targets and suggest that the acute involvement of GluA1-containing AMPA receptors tor forced swim behavior is a result of non-genomic mechanisms.

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Section: Discussionmentioning

confidence: 99%

Quantitative analysis of Gria1, Gria2, Dlg1 and Dlg4 expression levels in hippocampus following forced swim stress in mice

Freudenberg

2019

Sci Rep

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NMDA receptor dysregulation in chronic state: A possible mechanism underlying depression with BDNF downregulation

Vásquez

Riener

Reynolds

et al. 2014

Neurochemistry International

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Anxiolytic and antidepressive potentials of rosmarinic acid: A review with a focus on antioxidant and anti-inflammatory effects

Dahchour

2022

Pharmacological Research

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Behavior in a Forced Swimming Test and Expression of the Genes for a Neurotrophic Factor (BDNF) and Antiapoptotic Protein Bcl-xl

Cited by 3 publications

References 29 publications

Quantitative analysis of Gria1, Gria2, Dlg1 and Dlg4 expression levels in hippocampus following forced swim stress in mice

Quantitative analysis of Gria1, Gria2, Dlg1 and Dlg4 expression levels in hippocampus following forced swim stress in mice

NMDA receptor dysregulation in chronic state: A possible mechanism underlying depression with BDNF downregulation

Anxiolytic and antidepressive potentials of rosmarinic acid: A review with a focus on antioxidant and anti-inflammatory effects

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