Childhood disadvantage has repeatedly been linked to adult physical morbidity and mortality. We show in a prospective, longitudinal design that childhood poverty predicts multimethodological indices of adult (24 y of age) psychological well-being while holding constant similar childhood outcomes assessed at age 9. Adults from low-income families manifest more allostatic load, an index of chronic physiological stress, higher levels of externalizing symptoms (e.g., aggression) but not internalizing symptoms (e.g., depression), and more helplessness behaviors. In addition, childhood poverty predicts deficits in adult short-term spatial memory.childhood disadvantage | psychological health | stress | helplessness | memory A n increasingly large body of work in public health and medicine reveals that childhood disadvantage is prospectively linked to adult physical morbidity and mortality (1-4). Moreover, early disadvantage may shape the long-term health trajectories of individuals in ways that are difficult to dislodge by subsequent upward social mobility. The present study builds upon and extends this life-course research on childhood disadvantage and adult physical health in two respects. First, we investigate psychological rather than physical health outcomes among adults as a function of childhood poverty. We examine multimethodological indices of adult psychological adjustment including mental health symptoms, short-term memory, helplessness behavior, and allostatic load. Second, because we have measures of these constructs early in childhood, we conduct prospective, longitudinal analyses, testing whether adults from more disadvantaged backgrounds manifest lower levels of psychological well-being 15 y later, independently of childhood well-being assessed at age 9.Thus, several measures of psychological well-being were investigated between ages 9 and 24 in relation to childhood poverty. The first of these, short-term memory, describes the number of bits of information individuals can hold in immediate memory. Short-term memory capacity is important because it influences the encoding of information into long-term memory and is associated with cognitive development among children (5, 6). Cross-sectional studies with elementary school children in two different samples reveal a positive association between household SES and shortterm memory span (7,8), and a field experiment shows that Mexican preschool children in households randomly receiving cash transfers of differing amounts, conditional on healthcare utilization and school attendance, yields a positive cash transfer dose-response for short-term memory (9). An important shortcoming in the poverty and memory literature is the paucity of longitudinal data, and no studies have investigated childhood SES and adult short-term memory.An aspect of psychological health that has garnered little attention in the poverty literature is helplessness. Disadvantaged children face a plethora of uncontrollable psychosocial (e.g., family turmoil) and physical (e.g., substandard ho...