Behavior Genetics

Spinath, Frank M.; Johnson, Wendy

doi:10.1002/9781444343120.ch10

Cited by 4 publications

(4 citation statements)

References 129 publications

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“…Other possible mechanism for EOO in children with maternally inherited RSVs may relate to the maternal attitudes and practices regarding child feeding during the rst years of life. There is strong evidence for the in uence of genetics in multiple human behaviors including eating and feeding practices (40). Shared genetic variants in family relatives may explain similar attitudes towards feeding.…”

Section: Discussionmentioning

confidence: 99%

Maternal transmission bias of inherited genetic variants in severe early-onset obesity

Pieri

Serra‐Juhé

Martín‐Rivada

et al. 2022

Preprint

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Background: Obesity is highly influenced by genetics, with stronger genetic component in severe early-onset obesity (EOO). Heterozygous rare sequence variants (RSVs) affecting genes of the leptin-melanocortin pathway and hypothalamic function cause EOO, with variable expressivity and incomplete penetrance. We aimed to define whether and how parental inheritance could influence expressivity and penetrance. Methods: Observational study, systematic review and meta-analysis of reported inherited likely pathogenic heterozygous RSVs associated to non-syndromic EOO in 17 candidate genes was performed. Parental phenotype and proband’s birthweight were obtained when available. Child-feeding practices in transmitting and non-transmitting mothers were compared in a subsample using a validated questionnaire. Results: We identified 38 studies reporting 216 children with EEO and inherited heterozygous RSVs in candidate genes. A significant maternal over-transmission was observed (61.6%, 1.66:1, p = 0.0004), higher for RSVs inherited from severely obese parents (84%, 5.2:1, p = 0.0005). Patients with maternally inherited RSVs had an increased birthweight compared with patients with non-maternally inherited RSVs. Transmitting mothers manifest lower perceived responsibility for child feeding behavior when compared to non-transmitting mothers of either obese or non-obese children. Conclusions: A maternal over-transmission bias of inherited dominant RSVs disrupting genes of the leptin-melanocortin pathway contributes to severe EOO. Thus, synergistic effects of RSVs present in both, transmitting mothers and their children, can explain the more severe phenotype in the children. Prenatal factors during gestation and postnatal deregulation of eating behavior due to maternal carelessness may contribute to this bias. Identification of this risk factor may be useful for early intervention to prevent long term consequences of severe EOO.

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Section: Discussionmentioning

confidence: 99%

Maternal transmission bias of inherited genetic variants in severe early-onset obesity

Pieri

Serra‐Juhé

Martín‐Rivada

et al. 2022

Preprint

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“…Like the twin design, these quantify pairwise similarity for a construct across several types of kinship pairs that differ in their genetic similarity. Unlike twin designs, the genetically related family members differ in whether they also shared a home environment growing up (e.g., biological parent-adopted child, adoptive parent-adopted child, adoptive siblings, stepparent and child; Spinath & Johnson, 2011).…”

Section: Methodsmentioning

confidence: 99%

Cognition and emotion: Family member similarity and intergenerational transmission.

Deater-Deckard,

Hong,

Bertrand

et al. 2024

Child Development at the Intersection of Emotion and Cognition (2nd Ed.).

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C hildren arrive in the world ready for cognitive and affective action and experience. Over time, they will develop into full-fledged cognitive regulators of their emotions. Guiding each child through this developmental journey is a set of experiences integrated with biological mechanisms. As individuals, children differ from each other in that biology (some aspects of which they are born with, e.g., structural differences in their genotypes) and in what they experience-even within the same household. These distinct influences work together within a family context and set of relationships. Our emphasis in the current chapter is that each person in the family is unique but that there also are clear patterns of family member resemblance (i.e., observed similarity) arising from familial transmission (i.e., causal mechanisms involving biological-environmental transactions) of cognitive and affective components of emotion regulation. We present examples of research on familial resemblance and transmission involving two cognitive emotion regulation processes: effortful control (EC) and executive functioning (EF), and their connections with negative emotions-anger/frustration and fearfulness in particular. Examining family member resemblance and transmission processes allows scientists to operationalize mechanisms more precisely and infer potential causal effects more accurately, which in turn informs improvements to prevention and intervention efforts.

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“…G × E modeling detects whether the contributions of genetic, shared, and nonshared environmental components on some phenotypes change as a result of including a moderator in the analysis. Although we cannot comment on all existing gene–environment interactions in this article, we discuss a few of the most replicated effects to better illustrate this definition (for an overview, see Dick, ; Spinath & Johnson, ).…”

Section: A Look At the Methods In Quantitative Behavioral Geneticsmentioning

confidence: 99%

“…Continued research is needed in on gene–environment interactions to understand when the shared environment is particularly influential. In general, we need more research that seeks to understand gene–environment interplay in the context of development (Burt, ; Spinath & Johnson, ).…”

Section: A Look At the Methods In Quantitative Behavioral Geneticsmentioning

confidence: 99%

Overview of Behavioral Genetics Research for Family Researchers

Samek

Koh

Rueter

2013

J of Family Theo & Revie

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This article provides an overview of the methods, assumptions, and key findings of behavioral genetics methodology for family researchers with a limited background. We discuss how family researchers can utilize and contribute to the behavioral genetics field, particularly in terms of conducting research that seeks to explain shared environmental effects. This can be done, in part, by theoretically controlling for genetic confounds in research that seeks to determine cause-and-effect relationships among family variables and individual outcomes. Gene–environment correlation and interaction are especially promising areas for the family researcher to address. Given the methodological advancements in the field, we also briefly comment on new methods in molecular genetics for studying psychological mental health disorders.

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Behavior Genetics

Cited by 4 publications

References 129 publications

Maternal transmission bias of inherited genetic variants in severe early-onset obesity

Maternal transmission bias of inherited genetic variants in severe early-onset obesity

Cognition and emotion: Family member similarity and intergenerational transmission.

Overview of Behavioral Genetics Research for Family Researchers

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