Behavior and bioactive properties of aqueous L-cysteine–AgNO3 solution at different pH

Vishnevetskii, D. V.; Semenova, E.M.; Averkin, Dmitry V.; Mekhtiev, Arif R.

doi:10.1016/j.mencom.2023.04.042

Cited by 2 publications

(4 citation statements)

References 21 publications

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“…The particle size distribution is a bimodal for all The UV spectra of the CSG are presented in Figure 2b. A similar picture is observed for all samples (Figure 2b, top): the position of the absorption bands at 315 and 390 nm [2], which is attributed to the formation of L-cysteine/Ag + complexes and the local surface plasmon resonance (LSPR) of AgNPs [23,26], respectively, does not change as the polymer is added to the CSS. Therefore, macromolecules do not destroy the CSS particle's structure.…”

Section: Characterization Of Gelssupporting

confidence: 73%

“…The pH of the gel without the polymer was 2.55. pH shifted to 2.9. and 3.1 for CSG/PVA (50 and 100 kDa, respectively). In work [30], it was shown that the ratio of deprotonated and protonated carboxyl groups that were located on the surface of particles [26] in CSS was 4:1. Thus, there was a possibility of hydrogen bonds forming between the CSS particles and PVA.…”

Section: Characterization Of Gelsmentioning

confidence: 99%

“…The sol-gel transition is initiated by the addition of low-molecular-weight electrolytes (e.g., sulfates and chlorides of metals) [25]. We recently studied in detail the structure of particles from which CYS-and NAC-silver-based sols and gels were formed and showed its effect on the cytotoxicity and bioactive activity of the final materials [23,26]. The selfassembly process in these systems leads to the formation of particles consisting of silver nanoparticles (AgNPs) or silver nanoclusters (AgNCs) in the form of "core" and CYS/Ag + or NAC/Ag + complexes as their "shell".…”

Section: Introductionmentioning

confidence: 99%

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Cysteine–Silver–Polymer Systems for the Preparation of Hydrogels and Films with Potential Applications in Regenerative Medicine

Vishnevetskii,

Mekhtiev,

Averkin

et al. 2023

Gels

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Herein, the problem concerning the poorer mechanical properties of gels based on low molecular weight gelators (LMWGs)—L-cysteine and silver nitrate—was solved by the addition of various polymers—polyvinyl alcohol (PVA), polyvinyl pyrrolidone (PVP) and polyethylene glycol (PEG)—to the initial cysteine–silver sol (CSS). The physicochemical methods of analysis—viscosimetry, UV spectroscopy, DLS, and SEM—identified that cysteine–silver hydrogels (CSG) based on PVA possess the best rheological properties and porous microstructure (the average pore size is 2–10 µm) compared to gels without the polymer or with PVP or PEG. Such gels are able to form cysteine–silver cryogels (CSC) and then porous cysteine–silver films (CSF) with an average pore size of 10–20 µm and good mechanical, swelling, and adhesion to skin characteristics as long as the structure of CSS particles remains stable. In vitro experiments have shown that hydrogels are non-toxic to normal human fibroblast cells. The obtained materials could potentially be applied to regenerative medicine.

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Section: Characterization Of Gelssupporting

confidence: 73%

Section: Characterization Of Gelsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Cysteine–Silver–Polymer Systems for the Preparation of Hydrogels and Films with Potential Applications in Regenerative Medicine

Vishnevetskii,

Mekhtiev,

Averkin

et al. 2023

Gels

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“…The outer side of the "shell" is formed by amino and carboxyl groups. The isoelectric point (pI) of such a system is 5.5 [41], that is, the nanoparticles have a positive surface charge value, which is responsible for the sol's colloidal stability. The system behaves like globular protein.…”

Section: Visual Analysis Of Sol-gel Transition Processmentioning

confidence: 99%

Fluoride-Ion-Responsive Sol–Gel Transition in an L-Cysteine/AgNO3 System: Self-Assembly Peculiarities and Anticancer Activity

Vishnevetskii,

Andrianova,

Polyakova

et al. 2024

Gels

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Supramolecular hydrogels based on low-molecular-weight compounds are a unique class of so-called “soft” materials, formed by weak non-covalent interactions between precursors at their millimolar concentrations. Due to the variety of structures that can be formed using different low-molecular-weight gelators, they are widely used in various fields of technology and medicine. In this study, we report for the first time an unusual self-assembly process of mixing a hydrosol obtained from L-cysteine and silver nitrate (cysteine–silver sol—CSS) with sodium halides. Modern instrumental techniques such as viscosimetry, UV spectroscopy, dynamic light scattering, zeta potential measurements, SEM and EDS identified that adding fluoride anions to CSS is able to form stable hydrogels of a thixotropic nature, while Cl−, Br− and I− lead to precipitation. The self-assembly process proceeds using a narrow concentration range of F−. An increase in the fluoride anion content in the system leads to a change in the gel network morphology from elongated structures to spherical ones. This fact is reflected in a decrease in the gel viscosity and a number of gel–sol–gel transition cycles. The mechanism of F−’s interaction with hydrosol includes the condensation of anions on the positive surface of the CSS nanoparticles, their binding via electrostatic forces and the formation of a resulting gel carcass. In vitro analysis showed that the hydrogels suppressed human squamous carcinoma cells at a micromolar sample concentration. The obtained soft gels could have potential applications against cutaneous malignancy and as carriers for fluoride anion and other bioactive substance delivery.

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Behavior and bioactive properties of aqueous L-cysteine–AgNO3 solution at different pH

Cited by 2 publications

References 21 publications

Cysteine–Silver–Polymer Systems for the Preparation of Hydrogels and Films with Potential Applications in Regenerative Medicine

Cysteine–Silver–Polymer Systems for the Preparation of Hydrogels and Films with Potential Applications in Regenerative Medicine

Fluoride-Ion-Responsive Sol–Gel Transition in an L-Cysteine/AgNO3 System: Self-Assembly Peculiarities and Anticancer Activity

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