Beginning or end? Telomere structure, genetics and biology

Kipling, David; Cooke, Howard J.

doi:10.1093/hmg/1.1.3-a

Cited by 22 publications

(5 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These data, together with those regarding the possible relationships between telomeric sequences and chromosomal radiosensitivity (2,6,26), further highlight the unusual molecular genetic properties of these sequences (22,27,28) and their potential role in DNA damage responses. The elucidation of the genetics of these responses in the CBA/H and other mouse strains showing susceptibility or resistance to AML may provide insights into the genetics of human leukemogenesis and, in doing so, also contribute to the current debate on the possible association between paternal low-dose radiation exposure and leukemia in offspring (29)(30)(31)(32).…”

Section: Discussionmentioning

confidence: 81%

Telomere-like DNA polymorphisms associated with genetic predisposition to acute myeloid leukemia in irradiated CBA mice.

Silver¹,

Cox²

1993

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

There is evidence that interstitial telomere (TTAGGG)n-like sequences at chromosome 2 fragile sites play an important role in the somatic events that characterize the earliest phases of radiation-induced acute myeloid leukemia in the CBA/H mouse. Here we show that the highly inbred CBA/H colony unexpectedly contains four genotypic variants for telomere-like sequence arrays and that almost all induced myeloid leukemias derive from one of the variant subpopulations that constitutes approximately 20% of the colony. Preliminary evidence on the irregular inheritance patterns for these variant sequences is discussed together with the proposal that one form of these telomere sequence arrays either represents or is closely linked to a locus that influences chromosome 2 breakage patterns in hemopoietic cells following irradiation and, through this, susceptibility to induced myeloid leukemia.

show abstract

Section: Discussionmentioning

confidence: 81%

Telomere-like DNA polymorphisms associated with genetic predisposition to acute myeloid leukemia in irradiated CBA mice.

Silver¹,

Cox²

1993

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

show abstract

“…Additionally, it is also possible that the length and retention of telomeres is specific to the strain of vertebrate species that is housed and bred in a given animal facility. This is evidenced by the fact that mice of different strains can have varied telomere length measurements [17], [18].…”

Section: Discussionmentioning

confidence: 99%

Expression of Telomerase and Telomere Length Are Unaffected by either Age or Limb Regeneration in Danio rerio

et al. 2009

View full text Add to dashboard Cite

BackgroundThe zebrafish is an increasingly popular model for studying many aspects of biology. Recently, ztert, the zebrafish homolog of the mammalian telomerase gene has been cloned and sequenced. In contrast to humans, it has been shown that the zebrafish maintains telomerase activity for much of its adult life and has remarkable regenerative capacity. To date, there has been no longitudinal study to assess whether this retention of telomerase activity equates to the retention of chromosome telomere length through adulthood.Methodology/Principal FindingsWe have systematically analyzed individual organs of zebrafish with regard to both telomere length and telomerase activity at various time points in its adult life. Heart, gills, kidney, spleen, liver, and intestine were evaluated at 3 months, 6 months, 9 months, and 2 years of age by Southern blot analysis. We found that telomeres do not appreciably shorten throughout the lifespan of the zebrafish in any organ. In addition, there was little difference in telomere lengths between organs. Even when cells were under the highest pressure to divide after fin-clipping experiments, telomere length was unaffected. All aged (2 year old) tissues examined also expressed active amounts of telomerase activity as assessed by TRAP assay.Conclusions/SignificanceIn contrast to several other species including humans, the retention of lifelong telomerase and telomeres, as we have reported here, would be necessary in the zebrafish to maintain its tremendous regenerative capacity. The ongoing study of the zebrafish's ability to maintain telomerase activity may be helpful in unraveling the complexity involved in the maintenance (or lack thereof) of telomeres in other species such the mouse or human.

show abstract

“…Human telomeric DNA is made up of 2-20 kb of highly conserved, simple repeat sequences (TTAGGG)n [Moyzis et al, 1988]. Immediately adjacent to these are the subtelomeric sequences [Brown et al, 1990 andreviewed in Blackburn, 1991;Kipling and Cooke, 1992;Zakian, 1995]. The function of these subtelomeric sequences is unknown, as there are various lines of evidence showing that the simple repeats alone, in the absence of subtelomeric repeats, are capable of providing the necessary function of a human telomere [Brown et al, 1990;Wilkie et al, 1990;Flint et al, 1994].…”

Section: Discussionmentioning

confidence: 99%

Familial complex chromosome rearrangement giving rise to balanced and unbalanced recombination products

1998

View full text Add to dashboard Cite

We report on a family ascertained through a 14-month-old girl with a terminal deletion of chromosome 8p23.1. Analysis of the karyotype of other relatives showed that the mother is the carrier of a balanced complex 4-break chromosome rearrangement, which she and her brother inherited from their father following recombination. This complex chromosome rearrangement (CCR) was confirmed by fluorescence in-situ hybridization (FISH) using libraries for chromosomes 1, 8, and 9, and telomeric probes for the long arm of chromosome 9. The karyotype of the maternal grandfather was 46,XY,t(1;8) (p31;q21.1),t(8;9) (p23.1;q34). The karyotype of his daughter is 46,XX,rec(8)t(1;8) (p31;q21.1)t(8;9)(p23.1;q34)pat. The karyotype of the proposita is 46,XX,rec(8)t(8;9) (p23.1;q34)mat, and that of her abnormal elder sister is 46,XX,t(1;8)(p31;q21.1)rec(8) t(8;9) (p23.1;q34)mat,der(9)t(8;9) (p23.1;q34) mat. Unbalanced segregation and/or recombination during maternal meiosis gave rise to the two abnormal sisters, one effectively with 8p trisomy and the other with monosomy for that same 8p segment. To our knowledge, this is the first case of a familial CCR giving rise to unbalanced recombination products.

show abstract

Beginning or end? Telomere structure, genetics and biology

Cited by 22 publications

References 0 publications

Telomere-like DNA polymorphisms associated with genetic predisposition to acute myeloid leukemia in irradiated CBA mice.

Telomere-like DNA polymorphisms associated with genetic predisposition to acute myeloid leukemia in irradiated CBA mice.

Expression of Telomerase and Telomere Length Are Unaffected by either Age or Limb Regeneration in Danio rerio

Familial complex chromosome rearrangement giving rise to balanced and unbalanced recombination products

Contact Info

Product

Resources

About