Beeinflussung des Calcium-Austauschs und der Muskelfunktion des M. rectus und sartorius des Frosches durch Chlorpromazin, Prenylamin, Imipramin und Reserpin

Balzer, H.; Hellenbrecht, D.

doi:10.1007/978-3-662-39718-3_176

Cited by 2 publications

(10 citation statements)

References 7 publications

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“…I n a whole muscle, these effects may lead to an incomplete activation of some of the fibres and in this way cause a diminution of both twitch and tetanus tensions. Supporting this explanation is the fact that the reduction of twitch amplitude reported by Balzer and Hellenbrecht (1969) could to some extent be counteracted by raising the strength of the stimulus.…”

Section: Discussionmentioning

confidence: 94%

“…Kopera and Armitage (1954) found that chlorpromazine, after a transient potentiation, reduced the contraction response to both direct and indirect stimulation in the gastrocnemius muscle of the cat, and the same actions on frog sartorius (Isaacson and Sandow 1967) and on crab muscle (Huddart 197 1 ) have been reported for quinine. Balzer and Hellenbrecht ( 1969), working with the sartorius and rectus abdominis muscles of the frog, also found that chlorpromazine and quinidine caused a diminished tension output. The present results, however, clearly demonstrate that chlorpromazine < 1 0-5 M, imipramine and quinidine < 5 x 10-5 M, concentrations that do not block the electrical activity, can potentiate the twitch response to direct stimulation of single muscle fibres.…”

Section: Discussionmentioning

confidence: 98%

“…They also lower the mechanical threshold and prolong the relaxation phase of potassium-induced contractures in single skeletal muscle fibres (Anderson 1972 a ) . Furthermore, these drugs are membrane stabilizers a, b, Seeman 1966, Langslet 1970, Langslet et al 1971 and inhibit the passage of calcium and other ions across cell membranes (van Zwieten 1969, Balzer andHellenbrecht 1969). I t has been suggested that, because of these effects, the drugs would be able to inhibit the release of calcium from the sarcoplasmic reticulum and thus diminish the contractile response to direct stimulation of the muscle (Balzer and Hellenbrecht 1969).…”

mentioning

confidence: 99%

“…Reports on the effects of chlorpromazine and imipramine on tension development of electrically stimulated skeletal muscle are sparse. However, in frog sartorius and rectus abdominis muscles, chlorpromazine was shown to diminish the twitch amplitude (Balzer and Hellenbrecht 1969). Quinidine and its optical isomer quinine, on the other hand, have been more extensively investigated and are known to potentiate the twitch response (Harvey 1939, Krayer and George 1951, Isaacson, Yamaji and Sandow 1970 by prolonging the duration of the active state (Lammers and Ritchie 1955).…”

mentioning

confidence: 99%

“…Quinidine and its optical isomer quinine, on the other hand, have been more extensively investigated and are known to potentiate the twitch response (Harvey 1939, Krayer and George 1951, Isaacson, Yamaji and Sandow 1970 by prolonging the duration of the active state (Lammers and Ritchie 1955). Reports of a reduced tension development in the twitch induced by quinidine have also appeared (Balzer and Hellenbrecht 1969).…”

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confidence: 99%

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Effects of Chlorpromazine, Imipramine, and Quinidine on Action Potential and Tension Development in Single Skeletal Muscle Fibres of the Frog

Anderson

1973

Acta Physiologica Scandinavica

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ANDERSON, K.-E. Effects of chlorpromazine, imipramine, and quinidine on action potential and tension development in single skeletal muscle fibres of the frog.Acta physiol. scand. 1973. 88. 33&-341.The effects of chlorpromazine, imipramine, and quinidine on resting membrane potential, action potential, twitch and tetanic tensions, and on the active state were investigated in single frog skeletal muscle fibres. Chlorpromazine in concentrations 10-6-10'5 M, and imipramine and quinidine in concentrations 10-6-5 x M, did not affect the resting membrane potential but produced a dose-dependent decrease in the rate of rise, rate of fall, and overshoot of the action potential. The duration, measured at -50 mV, was prolonged. The drugs potentiated the isometric twitch by increasing the duration of the active state. Tetanic tension was not affected. I n high concentrations (chlorpromazine 3 x M, imipramine and quinidine > 5 x M) the drugs caused a successive widening and decrease of amplitude of the action potential and finally blocked the electrical activity. After a marked initial increase, the peak twitch tension was reduced in parallel with the changes of the action potential. The reduction in twitch amplitude was probably due to incomplete activation of the fibres. The mechanisms of the effects on the excitation-contraction coupling induced by chlorpromazine, imipramine, and quinidine are discussed.Solutions. The normal Ringer's solution had the following composition (mM) : NaCl 115.5, KCl 2.0, CaClz 1.8, NaHzP04-Na2HP04 2.0, pH 7.0.In some experiments, a hypertonic solution was used to mechanically inactivate the fibres. This solution was prepared by adding urea (final concentration 400 mM) to the normal Ringer's solution.All solutions were prepared on the day of the experiments. Double distilled water and analytical grade chemicals were used.

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Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 98%

mentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Effects of Chlorpromazine, Imipramine, and Quinidine on Action Potential and Tension Development in Single Skeletal Muscle Fibres of the Frog

Anderson

1973

Acta Physiologica Scandinavica

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Effects of Chlorpromazine, Imipramine, and Quinidine on the Mechanical Activity of Single Skeletal Muscle Fibres of the Frog

Andersson

1971

Acta Physiologica Scandinavica

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ANDERSSON, K.-E. Effects of chlorpromazine, imipramine, and quinidine on the mechanical activity of single skeletal muscle fibres of the frog. Acta physiol. scand. 1972. 85. 532-546. Chlorpromazine ( 8~ 10-0-3 x M), imipramine, and quinidine (5x 10-j-10-4 M )prolonged the relaxation phase of potassium induced contractures in single skeletal muscle fibres of the frog without affecting the maximum tension amplitude. These drugs also shifted the curve, which relates peak contracture tension to external potassium concentration, to lower potassium values and lowered the mechanical threshold. This is in contrast to other membrane stabilizers such as tetracaine, cocaine, and procaine, which have been reported to shift the curve to higher potassium values and .to increase the mechanical threshold. In high concentrations, chlorpromazine (lo-* M), imipramine, and quinidine (> M) produced slowly developing and only partially reversible contractures. Similar contractures could be evoked in fibres that were depolarized in isotonic potassium methyl sulphate solution and in fibres that had been soaked for 10-30 min in a calcium-free medium. The results support the idea that the contractile effects produced by chlorpromazine, imipramine, and quinidine are mediated by action upon intracellular calcium storing structures.

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Beeinflussung des Calcium-Austauschs und der Muskelfunktion des M. rectus und sartorius des Frosches durch Chlorpromazin, Prenylamin, Imipramin und Reserpin

Cited by 2 publications

References 7 publications

Effects of Chlorpromazine, Imipramine, and Quinidine on Action Potential and Tension Development in Single Skeletal Muscle Fibres of the Frog

Effects of Chlorpromazine, Imipramine, and Quinidine on Action Potential and Tension Development in Single Skeletal Muscle Fibres of the Frog

Effects of Chlorpromazine, Imipramine, and Quinidine on the Mechanical Activity of Single Skeletal Muscle Fibres of the Frog

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