Beeinflussen lokal applizierte Corticosteroide den Heilverlauf der Epidermophytien?

Abstract

During in vitro studies of the effect of hydrocortisone (50 mg/ml) and of Locorten (2 mg/ml) upon the growth rate of trichophyton mentagrophytes, trichophyton rubrum, microsporon gypseum and c. albicans neither a stimulating nor inhibiting effect could be demonstrated. Local application of Locorten ointment (Ciba) increased the rate of healing of experimental Trichophyton gypseum asteroides infection in guinea pigs.

Effects of Local Corticosteroids in Skin Infections

“…As to the effects of glucocorticoids applied topically in skin infections (and on infected skin lesions), three points have to be considered: (1) clinical effects of glucocorticoids on the infected, inflamed skin lesion; (2) the direct effects of glucocorticoids on the infecting microbes (fungi, bacteria, and vira), and (3) the interactions between glucocorticoids and antimicrobial substances when a combination preparation is used.…”