Beeinflussen Drug-eluting Stents das
Spektrum der Koronarchirurgie?

Matschke, Klaus; Tugtekin, Sems Malte; Kappert, Utz; Jung, F.; Park, Jai-Wun; Knaut, Michael

doi:10.1007/s00059-004-2561-9

Cited by 14 publications

(6 citation statements)

References 21 publications

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“…The stent is a good example for a commonly used, but not yet ideal device. Because polymer coatings tend to get partially destructed during dilatation, uncoated edges are generated, which can participate in protein adsorption and thrombocyte activation 270. Surface functionalization of PVC, silicone, or stents might increase the shelf life of blood products, decrease the necessity of drug treatment, and reduce the failure of implants as well as implant‐related complications.…”

Section: Bioinert and Biospecific Surfaces—recent Developments Andmentioning

confidence: 99%

Protein Interactions with Polymer Coatings and Biomaterials

et al. 2014

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Protein adsorption is considered to be the most important factor of the interaction between polymeric biomaterials and body fluids or tissues. Water-mediated hydrophobic and hydration forces as well as electrostatic interactions are believed to be the major factors of protein adsorption. A systematic analysis of various monolayer systems has resulted in general guidelines, the so-called "Whitesides rules". These concepts have been successfully applied for designing various protein-resistant surfaces and are being studied to expand the understanding of protein-material interactions beyond existing limitations. Theories on the mechanisms of protein adsorption are constantly being improved due to the fast-developing analytical technologies. This Review is aimed at improving these empirical guidelines with regard to present theoretical and analytical advances. Current analytical methods to test mechanistic hypotheses and theories of protein-surface interactions will be discussed. Special focus will be given to state-of-the-art bioinert and biospecific coatings and their applications in biomedicine.

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Section: Bioinert and Biospecific Surfaces—recent Developments Andmentioning

confidence: 99%

Protein Interactions with Polymer Coatings and Biomaterials

et al. 2014

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“…A stent undergoes mechanical constraints after implantation which results in a stent coating defect such as cracking, flaking, and delamination. Findings demonstrated requirements for a drug-eluting stent as follows (Farah 2018 ): First, the flexibility of a DES to make it possible to stretch without delamination or falling the stent apart (Tugtekin et al 2004 ). Second, the polymer is responsible to place drug agents in its structure so that therapeutic agents could be released at a sustained, controlled, and predictable rate (Levy et al 2009a ).…”

Section: Drug-eluting Stentsmentioning

confidence: 99%

Cardiovascular stents: overview, evolution, and next generation

et al. 2018

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Compared to bare-metal stents (BMSs), drug-eluting stents (DESs) have been regarded as a revolutionary change in coronary artery diseases (CADs). Releasing pharmaceutical agents from the stent surface was a promising progress in the realm of cardiovascular stents. Despite supreme advantages over BMSs, in-stent restenosis (ISR) and long-term safety of DESs are still deemed ongoing concerns over clinically application of DESs. The failure of DESs for long-term clinical use is associated with following factors including permanent polymeric coating materials, metallic stent platforms, non-optimal drug releasing condition, and factors that have recently been supposed as contributory factors such as degradation products of polymers, metal ions due to erosion and degradation of metals and their alloys utilizing in some stents as metal frameworks. Discovering the direct relation between stent materials and associating adverse effects is a complicated process, and yet it has not been resolved. For clinical success it is of significant importance to optimize DES design and explore novel strategies to overcome all problems including inflammatory response, delay endothelialization, and sub-acute stent thrombosis (ST) simultaneously. In this work, scientific reports are reviewed particularly focusing on recent advancements in DES design which covers both potential improvements of existing and recently novel prototype stent fabrications. Covering a wide range of information from the BMSs to recent advancement, this study mostly sheds light on DES’s concepts, namely stent composition, drug release mechanism, and coating techniques. This review further reports different forms of DES including fully biodegradable DESs, shape-memory ones, and polymer-free DESs.

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“…Based on the findings, the requirements for PCS have been established as follows [ 15 ]. Firstly, the flexibility of the PCS should allow stretching without delamination or disintegration of the stent [ 38 ]. Secondly, such a polymer should be selected to enable the pharmaceuticals placed in its structure to be released at a constant, controlled, and predictable rate [ 39 ].…”

Section: Drug-eluting Stents (Des)mentioning

confidence: 99%

Drug-Eluting Stents and Balloons—Materials, Structure Designs, and Coating Techniques: A Review

Rykowska

Nowak

Nowak³

2020

Molecules

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Controlled drug delivery is a matter of interest to numerous scientists from various domains, as well as an essential issue for society as a whole. In the treatment of many diseases, it is crucial to control the dosing of a drug for a long time and thus maintain its optimal concentration in the tissue. Heart diseases are particularly important in this aspect. One such disease is an obstructive arterial disease affecting millions of people around the world. In recent years, stents and balloon catheters have reached a significant position in the treatment of this condition. Balloon catheters are also successfully used to manage tear ducts, paranasal sinuses, or salivary glands disorders. Modern technology is continually striving to improve the results of previous generations of stents and balloon catheters by refining their design, structure, and constituent materials. These advances result in the development of both successive models of drug-eluting stents (DES) and drug-eluting balloons (DEB). This paper presents milestones in the development of DES and DEB, which are a significant option in the treatment of coronary artery diseases. This report reviews the works related to achievements in construction designs and materials, as well as preparation technologies, of DES and DEB. Special attention was paid to the polymeric biodegradable materials used in the production of the above-mentioned devices. Information was also collected on the various methods of producing drug release coatings and their effectiveness in releasing the active substance.

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Beeinflussen Drug-eluting Stents das Spektrum der Koronarchirurgie?

Abstract: Therefore, the question whether drug-eluting stents have an impact on the spectrum of bypass surgery cannot be fully answered at present.

Cited by 14 publications

References 21 publications

Protein Interactions with Polymer Coatings and Biomaterials

Protein Interactions with Polymer Coatings and Biomaterials

Cardiovascular stents: overview, evolution, and next generation

Drug-Eluting Stents and Balloons—Materials, Structure Designs, and Coating Techniques: A Review

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